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The Effects of Feeding Various Dietary Fats on the Development and Regression of Hypercholesterolemia and Atherosclerosis

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Diet and Atherosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 60))

Abstract

The factors responsible for the development of atherosclerosis and the dietary lipids influencing it can only be studied under well controlled conditions in the experimental animal (1). Among the many experimental models of this disease process that have been investigated, the progressive atheromatous arterial lesions produced in the Rhesus monkey utilizing the nutritional approaches pioneered by Taylor et al (2,3,4) offer a number of advantages. The Rhesus monkey atheormatous lesions tend to resemble the human disease process much more closely in morphologic characteristics, distribution and complications than those frequently studied in the rabbit, rat, fowl and dog. The large number of additional advantages and the relatively few disadvantages of using the Rhesus monkey model of atherosclerosis produced by dietary means have been reviewed recently (5) and will not be repeated here. Suffice it to say that most of the disadvantages of this experimental model can be overcome by diligent work.

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Authors and Affiliations

  1. The Department of Pathology and Specialized Center of Research in Atherosclerosis, University of Chicago, USA

    R. W. Wissler & D. Vesselinovitch

Authors
  1. R. W. Wissler
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  2. D. Vesselinovitch
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Editors and Affiliations

  1. Institute of Pharmacology, University of Milan, Milan, Italy

    Cesare Sirtori

  2. Institute for Systematic Medical Therapy, University of Rome, Rome, Italy

    Giorgio Ricci

  3. Giovanni Lorenzini Foundation, Milan, Italy

    Sergio Gorini

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© 1975 Plenum Press, New York

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Wissler, R.W., Vesselinovitch, D. (1975). The Effects of Feeding Various Dietary Fats on the Development and Regression of Hypercholesterolemia and Atherosclerosis. In: Sirtori, C., Ricci, G., Gorini, S. (eds) Diet and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 60. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9029-3_5

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  • DOI: https://doi.org/10.1007/978-1-4615-9029-3_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9031-6

  • Online ISBN: 978-1-4615-9029-3

  • eBook Packages: Springer Book Archive

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