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Mixed Function Oxidation and Intermediary Metabolism: Metabolic Interdependencies in the Liver

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Cytochromes P-450 and b5

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 58))

Abstract

The mixed function oxidation system located in the endoplasmic reticulum consists of a membrane-bound electron transport system with cytochrome P-450 as the terminal oxidase. The function of this system, as can be seen from a cursory inspection of other contributions to this volume, is to convert a wide variety of structurally dissimilar lipophilic compounds, such as drugs, into more polar products primarily by hydroxylation (1,2). The overall reaction requires equimolar amounts of NADPH and oxygen.

Supported, in part, by a grant from the National Institute of Alcohol Abuse and Alcoholism (AA-00288), a Career Development Award from the National Institute of Mental Health (K 2 MH 70, 155; RGT) and a grant from Deutsche Forschungsgemeinschaft, Sonderforschungsbereich 51 “Medizinische Molekularbiologie un Biochemie.”

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Author information

Authors and Affiliations

  1. Johnson Research Foundation, University of Pennsylvania, Philadelphia, Pennsylvania, 19174, USA

    Ronald G. Thurman & Donald P. Marazzo

  2. Institut für Physiologische Chemie und Physikalische Biochemie, Universität München, Munich, Germany

    Roland Scholz

Authors
  1. Ronald G. Thurman
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  2. Donald P. Marazzo
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  3. Roland Scholz
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Editor information

Editors and Affiliations

  1. Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    David Y. Cooper  & Otto Rosenthal  & 

  2. Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Robert Snyder  & Charlotte Witmer  & 

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© 1975 Plenum Press, New York

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Thurman, R.G., Marazzo, D.P., Scholz, R. (1975). Mixed Function Oxidation and Intermediary Metabolism: Metabolic Interdependencies in the Liver. In: Cooper, D.Y., Rosenthal, O., Snyder, R., Witmer, C. (eds) Cytochromes P-450 and b5 . Advances in Experimental Medicine and Biology, vol 58. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9026-2_25

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  • DOI: https://doi.org/10.1007/978-1-4615-9026-2_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9028-6

  • Online ISBN: 978-1-4615-9026-2

  • eBook Packages: Springer Book Archive

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