Abstract
In the past few years there have been several objections raised to the concept that adenosine is involved in reactive hyperemia and in the adjustment of coronary blood flow to myocardial needs. In some cases (1, 2, 3) the reports have essentially repudiated the hypothesis whereas in others (4, 5) the hypothesis has been modified. Furthermore, there is lack of agreement of experimental results bearing on certain aspects of the hypothesis. It is the purpose of this communication to consider the points raised by critics of the adenosine hypothesis and to attempt to clarify them where this seems possible.
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Bittar, N., and T.J. Pauly. Myocardial reactive hyperemia responses in the dog after aminophylline and lidoflazine. Am. J. Physiol. 220:812–815, 1971.
Juhran, W., and K. Dietmann. Zur Regelung der Coronardurch-blutung im akuten Sauerstoffmangel. Pflügers Arch. 315:105–109, 1970.
Kübier, W., P.G., Spieckermann, and H.J. Bretschneider. Influence of dipyridamole (Persantin) on myocardial adenosine metabolism. J. Mol. Cell. Cardiol. 1:23–38, 1970.
Jageneau, A.H.M., W.K.A. Schaper, and W. Van Gerven. Enhancement of coronary reactive hyperemia in unanesthetized pigs by an adenosine-potentiator (Lidoflazine). Naunyn-Schmiedebergs Arch. Pharmak. 265:16–23, 1969.
Juhran, W., E.M. Voss, K. Dietmann, and W. Schaumann. Pharmacological effects on coronary reactive hyperemia in conscious dogs. Naunyn-Schmiedebergs Arch. Pharmak. 269:32–47, 1971.
Hashimoto, K., S. Kumakura and I. Tanemura. Mode of action of adenine, uridine and cytidine nucleotides and 2, 6-bis(diethanol-amino)-4, 8-dipiperidinopyrimidino(5, 4-d) pyrimidine on the coronary, renal and femoral arteries. Arzneimittel-Forschung 14:1252–1254, 1964.
Afonso, S., G.S. O’Brien, and C.W. Crumpton. Enhancement of coronary vasodilating action of ATP and adenosine by lidoflazine. Circulation Res. 22:43–48, 1968.
Jageneau, A.H.M., W.K.A. Schaper. Potentiation of adenosine activity by low oral doses of lidoflazine. Nature 221:184–185, 1969.
Miura, M., S. Tominaga and K. Hashimoto. Potentiation of reactive hyperemia in the coronary and femoral circulation by the selective use of 2, 6-bis(diethanolamine)-4, 8-dipiperidino-pyrimido[5, 4-]pyridimine. Arzneimittel-Forschung. 17:976–979, 1967.
Bittar, N., and T.J. Pauly. Potentiation by dipyridamole of myocardial reactive hyperemia in the dog. Pharm. Res. Comm. 2:231–242, 1970.
Afonso, S. Inhibition of coronary vasodilating action of dipyridamole and adenosine by aminophylline in the dog. Circ. Res. 26:743–752, 1970.
Curnish, R.R., R.M. Berne, and R. Rubio. Effect of aminophyi-line on myocardial reactive hyperemia. Proc. Soc. Exp. Biol. Med. 141:593–598, 1972.
Berne, R.M., R. Rubio, and B.R. Duling. Vasoactive substances affecting the coronary circulation. In: Myocardial Ischemia, Excerpta Media, Holland, Int’l. Cong. Series 225, 28–43, 1971.
Rubio, R., R.M. Berne, and M. Katori. Release of adenosine in reactive hyperemia of the dog heart. Am. J. Physiol. 216: 56–62, 1969.
Schrader, J., R.M. Berne, and R. Rubio. Uptake and metabolism of adenosine by human erythrocyte ghosts. Am. J. Physiol. 223:159–166, 1972.
Rubio, R., R.M. Berne, and J.G. Dobson, Jr. Sites of adenosine porduction in cardiac and skeletal muscle (submitted for publication).
Rubio, R., and R.M. Berne. The release of adenosine by the normal myocardium and its relationship to the regulation of coronary resistance. Circulation Res. 25:407–415, 1969.
Jacob, M.I., and R.M. Berne. Metabolism of purine derivatives by the isolated cat heart. Am. J. Physiol. 198:322–326, 1960.
Wiedmeier, V.T., R. Rubio, and R.M. Berne. Incorporation and turnover of adenosine -U-14C in perfused guinea pig myocardium. Am. J. Physiol. 223:51–54, 1972.
Zimmer, H.-G., C. Trendelenburg, R. Kammermeier, and E. Gerlach. De novo synthesis of myocardial adenine nucleotides: Acceleration during recovery from oxygen deficiency. Circulation Res. (In press).
Katori, M., and R.M. Berne. Release of adenosine from anoxic hearts: Relationship to coronary flow. Circulation Res. 19:420–425, 1966.
Gellai, M., J.M. Norton, and R. Detar. Evidence for direct control of coronary vascular tone by oxygen. Circulation Res. 32:279–289, 1973.
Berne, R.M., R. Rubio, B. R. Duling, and V.T. Wiedmeier, Effects of acute and chronic hypoxia on coronary blood flow. Advances in Cardiol. 5:56–66, 1970.
Duling, B.R. Microvascular responses to alterations in oxygen tension. Circulation Res. 31:481–489, 1972.
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Berne, R.M., Rubio, R. (1973). Challenges to the Adenosine Hypothesis for the Regulation of Coronary Blood Flow. In: Bloor, C.M., Olsson, R.A. (eds) Current Topics in Coronary Research. Advances in Experimental Medicine and Biology, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9020-0_1
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DOI: https://doi.org/10.1007/978-1-4615-9020-0_1
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