Abstract
Suspensions of lymphoid cells from different tissues (spleen, lymph nodes, thymus and bone marrow) injected neonatally into syngeneic hosts yield low proportions of dividing donor cells in the spleen, thymus and bone marrow. In contrast, the ability of various inocula to colonize the lymph nodes differs greately and can in general be correlated with the content of circulating lymphocytes within the inoculum. The higher the proportion of circulating lymphocytes in the inoculum the higher the ability of that inoculum to colonize the host lymph nodes (1). However, the capacity of spleen inoculum to colonize the lymph nodes can be increased several fold if the neonatal recipient is thymectomized prior to cell injection (2). This phenomenon is shown to be specific, since the ability of the inoculum to colonize the other lymphoid organs remains unlatered (2,3). Thus, it was suggested that thymus, through unknown mechanism ensures selective entry of circulating lymphocytes into the lymph nodes.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Nakić, B., Springer, O., Kaštelan, A. and Mikuška, J. Immunology, 18:107. 1970.
Kaštelan, A., Nakić, B., Springer, O., Mikuska, J. and Volf, D., Immunology, 18:131, 1970.
Kaštelan, A., Nakić, B., Springer, O., and Kondic-Mitin, N., Proc.Yugosl.Immunol.Soc. , 1:9, 1969.
Ford, C.E., and Micklem, H.S., Lancet, i:359, 1963.
Marchesi, V.T., and Gowans, J.L., Proc. Roy.Soc.B., 159:283, 1964.
Parrott, D.M.V., De Sousa, M.A.B., and East, J., J. Exp. Med., 123:191. 1966.
Kaštelan, A. and Springer, O., to be published.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Plenum Press, New York
About this chapter
Cite this chapter
Kaštelan, A., Springer, O., Bunarević, A. (1973). Colonizing Capacity of Lymphoid Cells Injected into Syngeneic Hosts. In: Janković, B.D., Isaković, K. (eds) Microenvironmental Aspects of Immunity. Advances in Experimental Medicine and Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9017-0_7
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9017-0_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9019-4
Online ISBN: 978-1-4615-9017-0
eBook Packages: Springer Book Archive