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Microenvironmental Aspects of Immunity pp 301–306Cite as

Involution of the Thymus Dependent Lymphoid System

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 29))

Abstract

Evidence from clinical and experimental analyses has revealed deficiency of immune function with age in some individuals or animals and not in others (1–6). The immune deficiencies observed during aging are similar to those produced or accelerated by neonatal thymectomy (2–8). Cell mediated immunity deteriorates spontaneously at an earlier age in autoimmune susceptible strains than in autoimmune resistant strains of mice (2,5,8,9). We have suggested that there is a progressive quantitative loss of post-thymic cells during aging (2–4, 7).

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References

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Author information

Authors and Affiliations

  1. Departments of Laboratory Medicine and Pathology, Univ. of Minnesota, Minneapolis, Minnesota, USA

    E. J. Yunis, G. Fernandes, J. Smith, O. Stutman & R. A. Good

Authors
  1. E. J. Yunis
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  2. G. Fernandes
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  3. J. Smith
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  4. O. Stutman
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  5. R. A. Good
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Editor information

Editors and Affiliations

  1. Immunobiology Research Center Institute of Immunobiology and Virology and Microbiological Institute, University of Belgrade, Belgrade, Yugoslavia

    Branislav D. Janković  & Katarina Isaković  & 

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© 1973 Plenum Press, New York

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Yunis, E.J., Fernandes, G., Smith, J., Stutman, O., Good, R.A. (1973). Involution of the Thymus Dependent Lymphoid System. In: Janković, B.D., Isaković, K. (eds) Microenvironmental Aspects of Immunity. Advances in Experimental Medicine and Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9017-0_44

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  • DOI: https://doi.org/10.1007/978-1-4615-9017-0_44

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9019-4

  • Online ISBN: 978-1-4615-9017-0

  • eBook Packages: Springer Book Archive

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