Abstract
Delayed hypersensitivity reactions have been shown to be mediated by thymus-derived T lymphocytes (1,2). It is apparent from the specificity of delayed reactions and from the demonstration of T cell memory (3), that at some stage of differentiation, such cells are capable of recognizing specific antigenic determinants. It has been proposed that as in the case of B cells, the antigen recognition T cell is dependent on a surface immunoglobulin (Ig), the only molecule thus far identified with antigen combining sites (4). Experimental evidence of the presence of such Ig molecules on the T cell surface has been conflicting. Both positive and negative results have been obtained in 1) attempts to radioiodinate directly any surface Ig present on mouse thymocytes (5,6); 2) antigen binding studies (7,8); and 3) inhibition of T lymphocyte function with anti-Ig antisera (9,10). Since the agammaglobulinemic (aγ) chicken can be immunized to give a normal delayed hypersensitivity (DH) reaction, it provides an ideal system in which to study the nature of possible antigen receptor sites in a presumably sensitized population of T cells.
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© 1973 Plenum Press, New York
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Theis, G.A., Weinbaum, F., McArthur, W.P., Thorbecke, G.J. (1973). Some Cell Surface Properties of Thymus-Derived Lymphocytes in Bursectomized Chickens. In: Janković, B.D., Isaković, K. (eds) Microenvironmental Aspects of Immunity. Advances in Experimental Medicine and Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9017-0_18
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DOI: https://doi.org/10.1007/978-1-4615-9017-0_18
Publisher Name: Springer, Boston, MA
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