Abstract
The presence of toxic factors in various forms of injury must have been obvious to prehistoric man when he first experienced the relief following spontaneous drainage of an abscess. Within a few hours, the tachycardia, sweating, feeling of weakness, and malaise disappeared, and he could not help but speculate on the toxic effects of pus, the subject that concerns us now. This dramatic systemic response to the drainage of an abscess is, I think, one of the most solid indicators of the possibility that a toxic agent emanating from an area of injured tissue is responsible for many of the systemic effects of sepsis. To this day, the most striking response seen in septic patients follows the drainage of an abscess, the removal of a septic uterus, or the amputation of a septic gangrenous leg.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1972 Plenum Press, New York
About this chapter
Cite this chapter
Thal, A.P. (1972). Release of Toxic Agents in Septic Shock. In: Hinshaw, L.B., Cox, B.G. (eds) The Fundamental Mechanisms of Shock. Advances in Experimental Medicine and Biology, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9014-9_29
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9014-9_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9016-3
Online ISBN: 978-1-4615-9014-9
eBook Packages: Springer Book Archive