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Liver Metabolism and Energy Production in Staphylococcus aureus Septic Shock in Mice

  • Chapter
The Fundamental Mechanisms of Shock

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 23))

Abstract

In 5–28% of septic shock patients in different series, infections with gram-positive organisms were responsible for the sepsis. Most were caused by Staphylococcus aureus (5, 15). Extensive studies have been made of the many toxins produced by staphylococcal cells. Experimental studies have also been made of infections in animals, but the subtle biochemical interactions between host metabolism and a challenging infection with S. aureus have received scant attention (6). We have felt that nothing less than whole bacteria, with their many chemical products, and the whole living animal should be the objects of study initially. Our experiments have demonstrated the importance of hepatic metabolism, particularly in relation to glycolysis and mitochondrial function (36).

This research was supported by grants from the USPHS (AI 04046) and the Iowa Thoracic Society.

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Author information

Authors and Affiliations

  1. Infectious Disease Division, Department of Internal Medicine, University of Iowa Hospitals, Iowa City, Iowa, USA

    Ian M. Smith M.D. & Kanai L. Mukherjee Ph.D.

Authors
  1. Ian M. Smith M.D.
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  2. Kanai L. Mukherjee Ph.D.
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Editor information

Editors and Affiliations

  1. Veterans Administration Hospital Departments of Physiology-Biophysics and Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Lerner B. Hinshaw Ph.D.

  2. Learning Resources Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Barbara G. Cox (Editorial Consultant) (Editorial Consultant)

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© 1972 Plenum Press, New York

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Smith, I.M., Mukherjee, K.L. (1972). Liver Metabolism and Energy Production in Staphylococcus aureus Septic Shock in Mice. In: Hinshaw, L.B., Cox, B.G. (eds) The Fundamental Mechanisms of Shock. Advances in Experimental Medicine and Biology, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9014-9_24

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  • DOI: https://doi.org/10.1007/978-1-4615-9014-9_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9016-3

  • Online ISBN: 978-1-4615-9014-9

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