Skip to main content
SpringerLink
Log in

An In Vitro Model System for the Study of the Induction of Cellular Immunity

  • Chapter
Morphological and Functional Aspects of Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 12))

  • 52 Accesses

Abstract

The mixed lymphocyte interaction (MLI) observed when allogeneic lymphocytes are cultured together has been interpreted as an in vitro model system in which to study the alloimmune response. This interaction has been characterized by cell proliferation and transformation which are believed to be early events in the response. The demonstration of the development of specific effector cells in the MLI has been described (1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Häyry, P. and Defendi, V., Science 168:133, 1970.

    Article  PubMed  Google Scholar 

  2. Manson, L. A. and Simmons, T. Transplant. Proc. 1:498, 1969.

    PubMed  CAS  Google Scholar 

  3. Manson, L. A., Simmons, T., Mills, L., and Friedman, H., in D. R. McIntyre, Bd., Proc. 4th Leukocyte Culture Conf., New York Appleton-Century-Crofts, 1970.

    Google Scholar 

  4. Manson, L. A., Foschi, G. V., and Palm, J., J. Cell. Comp. Physiol. 61:109, 1963.

    Article  CAS  Google Scholar 

  5. Main, R. K., and Jones, M. J., Nature, Lond. 218:1251, 1968.

    Article  CAS  Google Scholar 

  6. Byrt, P. and Ada, G. L., Immunology, Lond. 17:503. 1969.

    CAS  Google Scholar 

  7. Foschi, G. V. and Manson, L. A., Nature, Lond. 225:853, 1970.

    Article  CAS  Google Scholar 

  8. Mishell, R. I. and Dutton, R. W.; Science 153:1004, 1966.

    Article  PubMed  CAS  Google Scholar 

  9. Marbrook, J., Lancet 2:1279. 1967.

    Article  PubMed  CAS  Google Scholar 

  10. Diener. E. and Armstrong, W, D., Lancet 2:1281, 1967.

    Article  PubMed  CAS  Google Scholar 

  11. Diener, E. and Armstrong, W. D., J. exp. Med. 129:591, 1969.

    Article  PubMed  CAS  Google Scholar 

  12. Manson, L. A., Hickey, C. A., and Palm, J., in L. A. Manson, Ed., Biological Properties of the Mammalian Surface Membrane, Philadelphia, Wistar Institute Press, 1968.

    Google Scholar 

  13. Hickey, C. A., Doctoral Thesis, University of Pennsylvania, 1968.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    T. Simmons & L. A. Manson

Authors
  1. T. Simmons
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. A. Manson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute for Medical Genetics, University of Uppsala, Uppsala, Sweden

    Kerstin Lindahl-Kiessling

  2. Department of Histology, Institute of Human Anatomy, University of Uppsala, Uppsala, Sweden

    G. Alm

  3. Biology Division, Oak Ridge National Laboratories, Oak Ridge, Tennessee, 37830, USA

    M. G. Hanna Jr.

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Plenum Press, New York

About this chapter

Cite this chapter

Simmons, T., Manson, L.A. (1971). An In Vitro Model System for the Study of the Induction of Cellular Immunity. In: Lindahl-Kiessling, K., Alm, G., Hanna, M.G. (eds) Morphological and Functional Aspects of Immunity. Advances in Experimental Medicine and Biology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9011-8_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9011-8_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9013-2

  • Online ISBN: 978-1-4615-9011-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation