Abstract
Germfree, colostrum-deprived piglets obtained by aseptic hysterectomy 3 to 5 days prior to term were devoid of immunoglobulins and their tissues were free of “background” antibody forming cells. They were immunologically “virgin”; however, they were highly immunologically competent as demonstrated by an excellent immune response upon antigenic stimulation (1,2,3). In the “true” primary immune response, the first antibody formed was 19SγG followed by 7SγG-immunoglobulins (4). These immunologically “virgin” piglets were used to investigate the cellular origin of the sequential synthesis of 19S to 7S antibody in the ontogeny of the immune response. This report presents briefly the histological changes of the lymphoid tissues in relation to the “true” primary immune response (5,6).
Research supported by USPHS grant No. AI-03439. Y.B. Kim is the recipient of RCDA K3-AI-37,388, USPHS.
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Kim, Y.B., Watson, D.W. (1971). Histological Changes of Lymphoid Tissues in Relation to the Ontogeny of the Immune Response in Germfree Piglets. In: Lindahl-Kiessling, K., Alm, G., Hanna, M.G. (eds) Morphological and Functional Aspects of Immunity. Advances in Experimental Medicine and Biology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9011-8_23
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