Abstract
Although human follicle-stimulating hormone (FSH) has been demonstrated to be effective in the initiation or restoration of human spermatogenesis (1), its use in the treatment of male infertility has had variable results (2). Various reports indicate that FSH has no effect on steroid biosynthesis in the testis (3,4) while others suggest a stimulating effect on testosterone and estrogen production (5). The present investigation was carried out to test the effect of a human FSH preparation on males with infertility of varying pathogenesis. In addition to following the response of the sperm count, the study included assay of pituitary and gonadal hormones in blood and urine and investigation of bio-synthetic pathways in small amounts of testicular tissue obtained at biopsy. Criteria were sought for grouping infertile patients in relation to response to therapy.
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Troen, P., Yanaihara, T., Nankin, H., Tominaga, T., Lever, H. (1970). Assessment of Gonadotropin Therapy in Infertile Males. In: Rosemberg, E., Paulsen, C.A. (eds) The Human Testis. Advances in Experimental Medicine and Biology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9008-8_42
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DOI: https://doi.org/10.1007/978-1-4615-9008-8_42
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