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Effect of Urinary FSH and LH on the Testicular Function in Hypogonadal Patients

  • Chapter
The Human Testis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 10))

Abstract

The effects of human chorionic (HCG), pregnant mare serum (PMS) or other animal pituitary gonadotropin preparations on the development of spermatogenesis in prepuberal and postpuberal cases of hy-pogonadotropic hypogonadism have generally been disappointing (1–5). Although it has long been admitted that large doses and long term administration of HCG clearly stimulate the development and function of Leydig cells together with the appearance of secondary sexual signs, some discrepancies still remain with regard to its effect on the germinal epithelium and connective tissue structures of the tubular wall. It seems that only those cases with previous histological evidence of advanced meiotic process may respond successfully with production of spermatozoa (6,7). On the other hand, gonadotropins of animal origin seem to be able to stimulate weakly both Leydig and germinal cells; this restricted action may be imputable to the long known induction of antigonadotropins (1,3). However, results obtained in similar hypogonadal conditions seem to be more encouraging, with the use of human urinary menopausal (HMG) and pituitary gonadotropins (HPG) administered singly or combined with HCG. Their human origin and both FSH and LH activity are the main advantages of these preparations.

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Authors and Affiliations

  1. Facultad de Medicina, Centro de Investigaciones sobre Reproduccion, Paraguay 2155, Piso 10, Buenos Aires, Argentina

    Roberto E. Mancini

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  1. Roberto E. Mancini
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Editors and Affiliations

  1. Medical Research Institute of Worcester, Inc., Worcester City Hospital, Worcester, Massachusetts, USA

    Eugenia Rosemberg M. D. (Research Director) (Research Director)

  2. University of Washington School of Medicine, Seattle, Washington, USA

    C. Alvin Paulsen M. D. (Professor of Medicine) (Professor of Medicine)

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© 1970 Plenum Press, New York

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Mancini, R.E. (1970). Effect of Urinary FSH and LH on the Testicular Function in Hypogonadal Patients. In: Rosemberg, E., Paulsen, C.A. (eds) The Human Testis. Advances in Experimental Medicine and Biology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9008-8_40

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  • DOI: https://doi.org/10.1007/978-1-4615-9008-8_40

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9010-1

  • Online ISBN: 978-1-4615-9008-8

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