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Investigations Into the Feed-Back Mechanism Between Spermatogenesis and Gonadotropin Level in Man

  • Chapter
The Human Testis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 10))

Abstract

It is a well established fact that there is a close relationship between spermatogenesis and gonadotropins. Selective damage of the germinal epithelium can easily be induced experimentally or found clinically and it has been shown by many authors that spermatogenetic failure is associated with castration changes in the hypophysis and increase in the gonadotropin level. The cause of spermatogenetic damage is unimportant. Hypophyseal changes have been shown to occur after anti-spermatogenetic compounds (1, 2), cadmium(3), radiation (4), testicular ischemia (5), cryptorchidism (6, 7, 8) and in various testicular disorders in man (9–14). When there is a failure of spermatogenesis, the gonadotropin rise primarily affects FSH (7, 14, 15), although LH also seems to be involved (16).

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Author information

Authors and Affiliations

  1. Hormone Department, Statens Seruminstitut, Copenhagen, Denmark

    Svend G. Johnsen

  2. the Male Hypogonadism Study Section, Medical Out-patients’ Department, University Hospital of Copenhagen, Denmark

    Svend G. Johnsen

Authors
  1. Svend G. Johnsen
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Editors and Affiliations

  1. Medical Research Institute of Worcester, Inc., Worcester City Hospital, Worcester, Massachusetts, USA

    Eugenia Rosemberg M. D. (Research Director) (Research Director)

  2. University of Washington School of Medicine, Seattle, Washington, USA

    C. Alvin Paulsen M. D. (Professor of Medicine) (Professor of Medicine)

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© 1970 Plenum Press, New York

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Johnsen, S.G. (1970). Investigations Into the Feed-Back Mechanism Between Spermatogenesis and Gonadotropin Level in Man. In: Rosemberg, E., Paulsen, C.A. (eds) The Human Testis. Advances in Experimental Medicine and Biology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9008-8_18

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  • DOI: https://doi.org/10.1007/978-1-4615-9008-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9010-1

  • Online ISBN: 978-1-4615-9008-8

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