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Purification and Chemistry of Gonadotropin Releasing Factors

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The Human Testis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 10))

Abstract

Although the humoral mechanism for the control of secretion of pituitary gonadotropins has been proposed for many years (1, 2), the first attempts to demonstrate the presence of an LH (luteinizing hormone)-releasing factor (LRF) in hypothalamic extracts are relatively recent. It was actually Harris and Campbell et al. (3, 4) and McCann et al. (5, 6) who in 1960 independently demonstrated the presence of LRF in the acid extracts of cattle and rat hypothalamus. The existence in hypothalamic extracts of an LRF capable of stimulating release of LH has now been established in the following nine species: rat (5–8), cattle (4, 9–11), sheep (8, 11–14), pig (14), rabbit and dog (10, 15), monkey (10), guinea pig (16, 17) and man (18). Although LRF from some of these species has been prepared in a highly purified state, nobody, to our knowledge, has obtained pure LRF.

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Authors and Affiliations

  1. Laboratoire de Physiologie Cellulaire, College de France, 11, Place Marcelin Berthelot, Paris Ve, France

    Marian Jutisz

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  1. Marian Jutisz
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Editors and Affiliations

  1. Medical Research Institute of Worcester, Inc., Worcester City Hospital, Worcester, Massachusetts, USA

    Eugenia Rosemberg M. D. (Research Director) (Research Director)

  2. University of Washington School of Medicine, Seattle, Washington, USA

    C. Alvin Paulsen M. D. (Professor of Medicine) (Professor of Medicine)

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© 1970 Plenum Press, New York

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Jutisz, M. (1970). Purification and Chemistry of Gonadotropin Releasing Factors. In: Rosemberg, E., Paulsen, C.A. (eds) The Human Testis. Advances in Experimental Medicine and Biology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9008-8_16

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  • DOI: https://doi.org/10.1007/978-1-4615-9008-8_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9010-1

  • Online ISBN: 978-1-4615-9008-8

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