Abstract
Aspergillus nidulans was first described in detail by Eidam (1883) and more recently has been reviewed thoroughly by Thorn and Raper (1945). It was exploited genetically by Pontecorvo et al. (1953) partly because of its challenge as a homothallic filamentous fungus and partly because it seemed likely to have characteristics which would make it favorable for an approach to a variety of problems. Some of its merits, as they can be seen now, are the following: it grows on a chemically defined medium over a wide temperature range; its colonial growth form makes it suitable for examination of many discrete colonies and for detection of sectors within colonies; it produces abundant, darkly pigmented vegetative spores which are uninucleate and haploid; mutant strains are produced readily and include types differing from wild type in colony morphology, color of conidia or ascospores, nutritional requirements, ability to grow on various sugars, and resistance to inhibitory agents ; although it is self-fertile, heterokaryosis permits the use of the sexual cycle for genetic analysis ; the vegetative nuclei are normally haploid, but strains with relatively stable diploid nuclei can be selected and used in tests of gene action and in novel forms of genetic analysis not available in the standard sexual cycle. These features are seen best in a summarized account of the life and nuclear cycles.
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Roper, J.A. (1971). Aspergillus. In: Hollaender, A. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8969-3_2
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