Advertisement

Liquid Crystalline Interactions Between Cholesteryl Esters and Phospholipids

  • Martin J. Janiak
  • Carson R. Loomis

Abstract

Among the many organic compounds which form liquid crystalline states, phospholipids and cholesteryl esters are naturally occurring, biologically important molecules. Phospholipids are the major lipid components of cell membranes (1) and together with cholesteryl esters comprise the bulk of lipids found in the circulating lipoproteins of the serum (2). The liquid crystalline nature of these lipids has been shown to be intrinsically important in the structure of both membranes and low density serum lipoproteins (3–5). Certain diseases, in particular atherosclerosis, are associated with the accumulation of phospholipid and cholesteryl ester (6,7). In atherosclerosis, these lipids have been shown to be primarily in their liquid crystalline states at physiological temperature (8).

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rouser, G., Nelson, G.J., Fleischer, S. and Simon, G. Biological Membranes, Vol. I, Academic Press (1968).Google Scholar
  2. 2.
    Blood Lipids and Lipoproteins: Quantitation, Composition and Metabolism (Nelson, G.J., ed.) Wiley-Interscience, N.Y. (1972).Google Scholar
  3. 3.
    Shipley, G.G., Biological Membranes, Vol. II, Academic Press, N.Y. (1973).Google Scholar
  4. 4.
    Deckelbaum, R.J., Shipley, G.G.; Small, D.M., Lees, R.S. and George, A.K. Science. (1975) 190, 392.CrossRefGoogle Scholar
  5. 5.
    Atkinson, D., Deckelbaum, R.J., Small, D.M. and Shipley, G.G. Proc. Nat. Acad. Sei. (1977), 74, 1042.Google Scholar
  6. 6.
    Lipid Storage Diseases (J. Bernsohn and H.J. Grossman, eds.) Academic Press, N.Y.(1971).Google Scholar
  7. 7.
    Atherosclerosis (R.J. Jones, ed.) Springer-Verlag, N.Y. (1970).Google Scholar
  8. 8.
    Katz, S.S., Shipley,G.G., and Small, D.M. J. Clin. Invest. (1976) 18, 200.CrossRefGoogle Scholar
  9. 9.
    Janiak, M.J., Loomis, C.R., Shipley, G.G. and Small, D.M. J. Mol. Biol. (1974) 86, 325.CrossRefGoogle Scholar
  10. 10.
    Loomis, C.R., Janiak, M.J., Small, D.M. and Shipley, G.G. J. Mol. Biol. (1976) 86, 309.CrossRefGoogle Scholar
  11. 11.
    Reiss-Husson, F.J.Mol. Biol. (1967) 25, 363.CrossRefGoogle Scholar
  12. 12.
    Small, D.M. J. Lip. Res. (1967) J3, 551.Google Scholar
  13. 13.
    Tardieu, A., Luzzati, V. and Reman, F.C. J. Mol. Biol. (1973) 75, 711.CrossRefGoogle Scholar
  14. 14.
    Small, D.M. Surface Chemistry of Biological Systems, Plenum Press, (1970).Google Scholar
  15. 15.
    Lecuyer, H. and Dervichian, D.G. J. Mol. Biol. (1969) 45, 39.CrossRefGoogle Scholar
  16. 16.
    Craven, B. and DeTitta, G.T. J. Chem. Soc. (1976) Perkins II, 814.CrossRefGoogle Scholar
  17. 17.
    Luzzati, V. Biological Membranes; Vol. II, Academic Press, N.Y. (1968).Google Scholar
  18. 18.
    Ashworth, L.A.E. and Green, C. Science (1966) 152, 210.CrossRefGoogle Scholar
  19. 19.
    Zambrano, F., Fleischer, S. and Fleischer, B. Biochim. Biophys. Acta (1970) J380, 357.Google Scholar
  20. 20.
    Tardieu, A., Mateu, L., Sardet, C., Weiss, B., Luzzati, V., Aggerbeck, L. and Scanu, A.M. J. Mol. Biol. (1976) 101, 129.CrossRefGoogle Scholar
  21. 21.
    Small, D.M. and Shipley, G.G. Science (1974) 185, 222.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Martin J. Janiak
    • 1
  • Carson R. Loomis
    • 1
  1. 1.Biophysics Section, Department of MedicineBoston University School of MedicineBostonUSA

Personalised recommendations