Abstract
Current interest in the genetic control of the immune response to chemically well defined natural and synthetic polypeptides gives clear indication of the necessity for us to understand the contribution of structure to the antigenicity of proteins (1). Previously biochemist and immunologist alike had concerned themselves with the relationship of protein structure to the diversity and specificity of the antibody elicited following immunization. In view of our present appreciation of the complex cellular interactions which occur between macrophages, T lymphocytes (both helper and suppressor) and B lymphocytes, it is necessary to precisely define the influence of antigen structure on the initial step in the antigen recognition process, namely at the level of macrophage-T cell interaction.
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References
Shreffler, D.C., and David, C.S., Adv. Immunol. 20, 125 (1975).
Blundell, T., Dodson, G., Hodgkins, D., and Mercola, D., Adv. Protein Chem. 26, 279 (1972).
Barcinski, M.A., and Rosenthal, A.S., J. Exp. Med. 145, 726, (1977).
Keck, K., Eur. J. Immunol. 5, 801 (1975).
Kolb, H., Keck, K., Momayezi, M., Schicker, C., and Trissl, D., J. Immunol. 118, 427 (1977).
Rosenwasser, L.J., Schwartz, R.H., and Rosenthal, A.S., (manuscript in preparation).
Bullock, W., Katz, D.H., and Benacerraf, B., J. Exp. Med. 142, 261 (1975).
Neta, R., and Salvin, S.B., J. Immunol. 117, 2014 (1976).
Arquilla, E., and Finn, J., J. Exp. Med. 122, 771 (1965).
Rosenthal, A.S., Barcinski, M.A., and Blake, J.T., Nature 267, 156 (1977).
Rosenthal, A.S., and Shevach, E.M., J. Exp. Med. 138, 1194 (1973).
Erb, P., Meier, B., and Feldmann, M., Nature 263, 601 (1976).
Katz, D.H., and Benacerraf, B., Transplant Rev. 22, 175 (1976).
Shevach, E.M., and Rosenthal, A.S., J. Exp. Med. 138, 1213 (1973).
Shevach, E.M., J. Immunol. 116, 1582 (1976).
Schwartz, R.H., David, C.S., Sachs, D.H., and Paul, W.E., J. Immunol. 117, 531 (1976).
Greineder, D.K., Shevach, E.M., and Rosenthal, A.S., J. Immunol. 117, 1261 (1976).
Pierce, C.W., Kapp, J.A., and Benacerraf, B., J. Exp. Med. 144, 371 (1976).
Miller, J.F.A.P., Vadas, M.A., Whitelaw, A., and Gamble, J., Proc. Nat. Acad. Sci. (USA) 73, 2486 (1976).
Thomas, D.W., and Shevach, E.M., J. Exp. Med. 144, 1263 (1976).
Zoschke, D.C., and Bach, F.H., Science 170, 1404 (1976).
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Rosenthal, A.S., Rosenwasser, L.J., Baskin, B.L., Schroer, J., Thomas, J.W., Blake, J.T. (1978). Genetic Control of the Immune Response to Insulin: Its Dependence Upon a Macrophage Mediated Selection of Distinct Antigenic Sites. In: Atassi, M.Z., Stavitsky, A.B. (eds) Immunobiology of Proteins and Peptides · I. Advances in Experimental Medicine and Biology, vol 98. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8858-0_26
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DOI: https://doi.org/10.1007/978-1-4615-8858-0_26
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