Immunoprophylaxis of Malaria: Sporozoite-Induced Immunity
- 107 Downloads
This chapter reviews the state of knowledge of immunization against malaria using sporozoites as immunizing agents and summarizes recent progress in this field. The demonstration of the immunogenicity of the sporozoite stage and of the occurrence of sporozoite-induced protection was first provided by the classical experiments of Mulligan et al. (1941) on avian malaria. Since then, a considerable amount of information on sporozoite-induced immunity has been obtained through experimental work using the rodent and, more recently, the simian malaria system. We intend to critically review these findings and to correlate them with the information obtained in preliminary vaccination attempts in humans, performed by immunization through the bite of infected irradiated mosquitoes (Clyde et al. 1973a, 1973b, 1975; Rieckmann et al. 1974). Furthermore, we will delineate what we consider to be some of the basic deficiencies in our knowledge of sporozoite-induced immunity and indicate some potentially productive future experimental approaches directed primarily at clarifying protective mechanisms and potentiating the sporozoite-induced immune response.
KeywordsBlood Parasite Immune Serum Plasmodium Berghei Immune Seron Avian Malaria
Unable to display preview. Download preview PDF.
- Chen, D. 1974. Aspects of host-parasite interactions in the rhesus P. cynomolgi-A. stephensi system. Ph.D. Thesis. New York University School of Medicine.Google Scholar
- Mulligan, H.W., Russell, P.F. & Mohan, B.N. 1941. Active immunization of fowls against Plasmodium gallinaceum by injections of killed homologous sporozoites. J. Malar. Inst. India. 4: 25–34.Google Scholar
- Spitalny, G. & Nussenzweig, R. 1972. Effect of various routes of immunization and methods of parasite attenuation on the development of protection against sporozoite-induced rodent malaria. Proc. Helminthol. Soc. Wash. 39: 506–514.Google Scholar
- Spitalny, G.L. & Nussenzweig, R.S. 1975a. Properties of antisporozoite antibodies against Plasmodium berghei. Submitted for publication.Google Scholar
- Spitalny, G.L., Verhave, J.P., Meuwissen, J.H.E. Th. & Nussenzweig, R.S. 1977 T-cell dependence of sporozoite-induced immunity in rodent malaria. Exp. Parasitol. Google Scholar
- Vanderberg, J., Nussenzweig, R., Sanabria, Y., Nawrot, D. & Most, H. 1972. Stage specificity of antisporozoite antibodies in rodent malaria and its relationship to protective immunity. Proc. Helminthol. Soc. Wash. 39: 514–525.Google Scholar
- Verhave, J.P. & Meuwissen, J.H.E. Th. 1974. Inhibition of exo-erythrocytic form development following reinoculation with sporozoites of P. berghei. In The Proceedings of the International Congress on Parasitology: 1243–1244.Google Scholar
- Ward, R.A. & Hayes, D.E. 1972. Attempted immunization of rhesus monkeys against cynomolgi malaria with irradiated sporozoites. Proc. Helminthol. Soc. Wash. 39: 525–529.Google Scholar