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Immunoprophylaxis Against Chagas’ Disease

  • Chapter
Immunity to Blood Parasites of Animals and Man

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 93))

Abstract

Chagas’ disease is caused by Trypanosoma cruzi, a flagellate protozoan transmitted by an hematophagus reduviid bug. This disease, identified by Dr. Carlos Chagas in 1909 (Chagas 1909, 1910), is a major public health problem in rural areas of Central and South America. Approximately 35 million people are estimated to be at risk of Trypanosoma cruzi infection, and at least 7 million have already been infected (Pan American Health Organization 1970). Human cases have been described from the southern United States to southern Argentina (Marsden 1971). Where Chagas’ disease is endemic, chronic myocarditis is the leading cause of sudden death and heart failure (Laranja et al. 1956). Certain digestive disturbances are also common manifestations of chronic Chagas’ disease (Vampré 1923; Prado 1945; Köberle & Nador 1955).

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  1. Faculdade de Ciencias da Suade, Universidade de Brasilia, Brasilia, Brazil

    Antonio R. L. Teixeira

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  1. National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA

    Louis H. Miller

  2. The Rockefeller Foundation, New York, New York, USA

    John A. Pino  & John J. McKelvey Jr.  & 

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Teixeira, A.R.L. (1977). Immunoprophylaxis Against Chagas’ Disease. In: Miller, L.H., Pino, J.A., McKelvey, J.J. (eds) Immunity to Blood Parasites of Animals and Man. Advances in Experimental Medicine and Biology, vol 93. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8855-9_13

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