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Controls of Nucleolar Function in Cancer Cells

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Book cover Morris Hepatomas

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 92))

Abstract

The protein synthesizing machinery of the cell in which the ribosomes play a key role is of great importance to its rate of growth (1). The availability of ribosomes is dependent upon the activity of the nucleolus (Fig 1), which is the sole site of synthesis of preribosomal RNA and of assembly of preribosomal particles. The high rate of protein synthesis is one reason why the attention of oncologists has been directed to analysis of nucleolar structure and function (2).

These studies were supported by the Cancer Research Center Grant CA-10893 awarded by the National Cancer Institute, DHEW, the Davidson Fund, the Wolff Memorial Foundation and a generous gift from Mrs. Jack Hutchins.

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Authors and Affiliations

  1. Department of Pharmacology, Baylor College of Medicine, Houston, Texas, 77030, USA

    H. Busch, N. R. Ballal, R. K. Busch, Y. C. Choi, F. Davis, I. L. Goldknopf, S. I. Matsui, M. S. Rao & L. I. Rothblum

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  1. H. Busch
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  2. N. R. Ballal
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  1. Department of Biochemistry and Howard Cancer Research Center, Howard University Medical School, Washington, D.C., USA

    Harold P. Morris  & Wayne E. Criss  & 

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Busch, H. et al. (1978). Controls of Nucleolar Function in Cancer Cells. In: Morris, H.P., Criss, W.E. (eds) Morris Hepatomas. Advances in Experimental Medicine and Biology, vol 92. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8852-8_7

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  • DOI: https://doi.org/10.1007/978-1-4615-8852-8_7

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