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Solid Tumor Models for the Assessment of Different Treatment Modalities: VI: Perturbations in the Kinetics of Tumor and Host Organ Cellular Regulation Demonstrated by Single and Combined Experimental Therapy

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Morris Hepatomas

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 92))

Abstract

The Morris hepatomas, the large series of over fifty different lines of transplantable rat hepatomas with multiple genetic, bio-chemical, metabolic and morphological changes, have been extensively used in cancer research. A correlation between tumor cell kinetics and tumor growth for this series of solid tumors was needed because many studies used tumor growth rates as reference points. The parameters of cell cycle time, growth fraction and cell loss factor, in addition to potential and actual volume doubling times, have been determined in nine Morris hepatomas.

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Author information

Authors and Affiliations

  1. Division of Radiobiology and Biophysics, University of Virginia, Charlottesville, Virginia, 22901, USA

    W. B. Looney, H. A. Hopkins & J. S. Trefil

Authors
  1. W. B. Looney
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  2. H. A. Hopkins
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  3. J. S. Trefil
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Editor information

Editors and Affiliations

  1. Department of Biochemistry and Howard Cancer Research Center, Howard University Medical School, Washington, D.C., USA

    Harold P. Morris  & Wayne E. Criss  & 

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© 1978 Plenum Press, New York

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Looney, W.B., Hopkins, H.A., Trefil, J.S. (1978). Solid Tumor Models for the Assessment of Different Treatment Modalities: VI: Perturbations in the Kinetics of Tumor and Host Organ Cellular Regulation Demonstrated by Single and Combined Experimental Therapy. In: Morris, H.P., Criss, W.E. (eds) Morris Hepatomas. Advances in Experimental Medicine and Biology, vol 92. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8852-8_27

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  • DOI: https://doi.org/10.1007/978-1-4615-8852-8_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8854-2

  • Online ISBN: 978-1-4615-8852-8

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