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The Synthesis and Secretion of Serum Albumin in Morris Hepatomas 5123tc and 9121

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Morris Hepatomas

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 92))

Summary

Invivo, Morris hepatomas 5123tc and 9121 do not secrete serum proteins into the bloodstream. However, they synthesize albumin, at a reduced rate, if compared with liver. The produced albumin accumulates, leading to an enlargement of the Golgi apparatus and the appearance of intracellular vesicles. The proportion and the absolute amount of albumin found within the hepatoma cells is increased compared with liver.

As described recently for liver in vivo and for hepatocyte suspensions, albumin is synthesized also in hepatoma cells via a precursor protein.

Hepatoma cells in culture secrete albumin into the medium. However, albumin accumulates in the cells with time in culture, indicating again a limited secretory capacity of the hepatoma cell.

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Author information

Authors and Affiliations

  1. The Russel Grimwade School of Biochemistry, University of Melbourne (G.S., J.U., H.D.), Melbourne (T.R.B.), Victoria, Australia

    Gerhard Schreiber, Jörg Urban, Heide Dryburgh & T. R. Bradley

  2. Peter MacCallum Cancer Institute, Melbourne (T.R.B.), Victoria, Australia

    Gerhard Schreiber, Jörg Urban, Heide Dryburgh & T. R. Bradley

Authors
  1. Gerhard Schreiber
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  2. Jörg Urban
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  3. Heide Dryburgh
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  4. T. R. Bradley
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Editor information

Editors and Affiliations

  1. Department of Biochemistry and Howard Cancer Research Center, Howard University Medical School, Washington, D.C., USA

    Harold P. Morris  & Wayne E. Criss  & 

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© 1978 Plenum Press, New York

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Schreiber, G., Urban, J., Dryburgh, H., Bradley, T.R. (1978). The Synthesis and Secretion of Serum Albumin in Morris Hepatomas 5123tc and 9121. In: Morris, H.P., Criss, W.E. (eds) Morris Hepatomas. Advances in Experimental Medicine and Biology, vol 92. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8852-8_22

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  • DOI: https://doi.org/10.1007/978-1-4615-8852-8_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8854-2

  • Online ISBN: 978-1-4615-8852-8

  • eBook Packages: Springer Book Archive

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