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Subcellular Compartmentalization of Hypothalamic Peptides: Characteristics and Ontogeny

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Hypothalamic Peptide Hormones and Pituitary Regulation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 87))

Abstract

It has been known for many years that the hypothalamus regulates the secretion of pituitary hormones. During the last decade, a number of peptides have been isolated from the hypothalamus which were shown to possess such regulatory functions. For example, the tripeptide thyrotropin releasing hormone (TRH) stimulates the secretion of thyroid stimulating hormone (1,2) and prolactin (3,4), and the decapeptide luteinizing hormone releasing hormone (LHRH) stimulates the secretion of gonadotropins (1,5). Although these peptides are of neuronal origin, they resemble non-neuronal polypeptide hormones in the fact that the anatomical location of their target tissues is remote from their site of production and storage. Such polypeptide hormones have been shown to be stored within granules which originate from the Golgi apparatus (6–9).

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  1. Charles Oliver

    Present address: Labortoire de Médecine Experimentale, U.E.R. Médecine Nord, Boulevard Pierre Dramard, Marseille, 13326, France

Authors and Affiliations

  1. Cecil H. & Ida Green Center for Reproductive Biology Sciences Departments of Obstetrics & Gynecology and Physiology, The University of Texas Health Science Center at Dallas Southwestern Medical School, Dallas, Texas, 75235, USA

    Ayalla Barnea, Charles Oliver & John C. Porter

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  1. Ayalla Barnea
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  1. University of Texas Health Science Center at Dallas, USA

    John C. Porter

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© 1977 Plenum Press, New York

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Barnea, A., Oliver, C., Porter, J.C. (1977). Subcellular Compartmentalization of Hypothalamic Peptides: Characteristics and Ontogeny. In: Porter, J.C. (eds) Hypothalamic Peptide Hormones and Pituitary Regulation. Advances in Experimental Medicine and Biology, vol 87. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8849-8_4

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  • DOI: https://doi.org/10.1007/978-1-4615-8849-8_4

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