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Studies on the Role of Luteinizing Hormone Releasing Factor in the Control of the Menstrual Cycle

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Hypothalamic Peptide Hormones and Pituitary Regulation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 87))

Abstract

Although considerable information has been obtained concerning the effect of steroids on the pituitary’s gonadotropic response to luteinizing hormone releasing factor (LRF), only recently has the physiological import of the interactions between LRF and the gonadal steroids on the functional status of gonadotrophs been studied. We have attempted, in human investigations, to delineate the operating characteristics of the pituitary gonadotrophs, as target cells, and to sort out the independent and combined effects of the controlling inputs-LRF, ovarian steroids, and catecholamines. These studies have yielded data on the functional changes in the pituitary during the course of the menstrual cycle and have also provided information concerning the contribution of the hypothalamic component of this system.

Supported by Rockefeller Foundation Grant RF75029.

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Authors and Affiliations

  1. Department of Reproductive Medicine School of Medicine, University of California, San Diego La Jolla, California, 92093, USA

    S. S. C. Yen, J. D. Hoff, B. L. Lasley, J. Rakoff & A. Lein

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  1. S. S. C. Yen
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  2. J. D. Hoff
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  3. B. L. Lasley
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  4. J. Rakoff
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  5. A. Lein
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Editors and Affiliations

  1. University of Texas Health Science Center at Dallas, USA

    John C. Porter

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© 1977 Plenum Press, New York

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Yen, S.S.C., Hoff, J.D., Lasley, B.L., Rakoff, J., Lein, A. (1977). Studies on the Role of Luteinizing Hormone Releasing Factor in the Control of the Menstrual Cycle. In: Porter, J.C. (eds) Hypothalamic Peptide Hormones and Pituitary Regulation. Advances in Experimental Medicine and Biology, vol 87. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8849-8_13

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  • DOI: https://doi.org/10.1007/978-1-4615-8849-8_13

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