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Dysplasia, Malformations and Cancer, Especially with Respect to the Wiedemann-Beckwith Syndrome

  • Chapter
Regulation of Cell Proliferation and Differentiation

Part of the book series: Cellular Senescence and Somatic Cell Genetics ((CSSCG))

Abstract

Changes in the cellular composition of our organs and tissues are occurring continuously from conception till death. If these changes lead to the appearance of structurally and/or functionally abnormal cells, either by change of a local cell type, or through immigration of cells foreign to the tissue or organ, or to physiological or microscopic evidence of progressive cellular malfunction or death, then they are frequently called degeneration by pathologists. These changes may be “normal” or abnormal, transient, relapsing or permanent. The most common “normal” prenatal degenerative changes are all of the genetically programmed types of cell death which occur at fixed times during organogenesis and which, for example, are responsible for our lack of a tail, the absence of webbing between our digits, the fact that we have separate urethral and anal outlets, the absence of heterosexual internal genitalia and so forth. Normal postnatal degenerative changes include all the “normal” cellular changes of aging, including the lamentable but apparently relentless loss of CNS ganglion cells, the atresia of millions of primary oocytes during the first few decades of a woman’s life, etc.

Supported by PHS/NIH Grants GM 15422, GM 20130 and 5 K04 HD 18982. Paper No. 1867 from the University of Wisconsin Genetics Laboratory.

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Authors and Affiliations

  1. Department of Pediatrics, University of Wisconsin Center for Health Sciences and Medical School, Madison, Wisconsin, 53706, USA

    Jürgen Herrmann, Enid F. Gilbert & John M. Opitz

  2. Department of Pathology, University of Wisconsin Center for Health Sciences and Medical School, Madison, Wisconsin, 53706, USA

    Enid F. Gilbert

  3. Wisconsin Clinical Genetics Center of the Department of Medical Genetics, University of Wisconsin Center for Health Sciences and Medical School, Madison, Wisconsin, 53706, USA

    Jürgen Herrmann & John M. Opitz

Authors
  1. Jürgen Herrmann
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  2. Enid F. Gilbert
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  3. John M. Opitz
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Editors and Affiliations

  1. Institute for Medical Research, Camden, New Jersey, USA

    Warren W. Nichols

  2. National Institute on Aging, Bethesda, Maryland, USA

    Donald G. Murphy

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© 1977 Plenum Press, New York

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Herrmann, J., Gilbert, E.F., Opitz, J.M. (1977). Dysplasia, Malformations and Cancer, Especially with Respect to the Wiedemann-Beckwith Syndrome. In: Nichols, W.W., Murphy, D.G. (eds) Regulation of Cell Proliferation and Differentiation. Cellular Senescence and Somatic Cell Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8846-7_1

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