Abstract
It has been known for some time that the insect skeletal (somatic) neuromuscular junction is different from vertebrate neuromuscular junction in terms of underlying neurochemistry and therefore responds to a completely different array of compounds. Because of its promise as a model site of action, around which it might be possible to develop selective insecticides, the insect nerve-muscle synapse has attracted considerable interest over the past 12 years.
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References
Anderson, C. R., Cull-Candy, S. G., and Miledi, R., 1976, Glutamate and quisqualate noise in voltage-clamped locust muscle fibres, Nature 261: 151–153.
Baxter, C. F., and Torralba, C. F., 1975, γ-aminobutyric acid and glutamate decarboxylase (L-glutamate 1-carboxylase E. C. 4.1.1.1.5) in the nervous system of the cockroach, Periplaneta amerioana. I. Regional distribution and properties of the enzyme, Brain Res. 84: 383–397.
Brown, B. E., 1975, Proctolin: a peptide transmitter candidate in insects, Life Sci. 17: 1241–1252.
Burrows, M., 1974, Modes of activation of motorneurons controlling ventilatory movements of the locust abdomen, Phil. Trans. Roy. Soo. Lond. B. 269: 29–48.
Burrows, M., 1975, Co-ordinating interneurons of the locust which convey two patterns of motor commands: their connexions with ventilatory motorneurons, J. Exp. Biol. 63: 735–753.
Chen, P. S., and Oechslin, A., 1976, Accumulation of glutamic acid in the paragonial gland of Drosophila nigromelanica, J. Insect Physiol. 22: 1237–1243.
Chiu, Y. C., Fahmy, M. A. H., and Fukuto, T. R., 1973, Aryl N-hydroxy- and N-methoxy-N-methylcarbamates as potent reversible inhibitors of acetylcholinesterase, Pestio. Bioohem. Physiol. 3: 1–6.
Clements, A. N., and May, T. E., 1974a, Studies on locust neuromuscular physiology in relation to glutamic acid, J. Exp. Biol. 60: 673–705.
Clements, A. N., and May, T. E., 1974b, Pharmacological studies on a locust neuromuscular preparation, J. Exp. Biol. 61: 421–442.
Cull-Candy, S. G., 1975, Effect of denervation and local damage on extrajunctional L-glutamate receptors in locust muscle, Nature 258: 530–531.
Cull-Candy, S. G., Donnellan, J. F., James, R. W., and Lunt, G. G., 1976, 2-amino-4-phosphonobutyric acid as a glutamate antagonist on locust muscle, Nature 262: 408–409.
Daoud, A., and Usherwood, P. N. R., 1975, Action of kainic acid on a glutaminergic synapse, Comp. Biochem. Physiol. 52C: 51–53.
Dowson, R. J., and Usherwood, P. N. R., 1972, The effect of low concentrations of L-glutamate and L-aspartate on transmitter release at the locust excitatory nerve-muscle synapse, J. Physiol. 229: 13–14.
Dowson, R. J., Clements, A. N., and May, T. E., 1975, The action of some Harmala alkaloids on transmission at a glutamate-mediated synapse, Neuropharmacol. 14: 235–240.
Evans, P. D., 1975, The uptake of L-glutamate by the central nervous system of the cockroach, Periplaneta americana, J. Exp. Biol. 62: 55–67.
Fraser Rowell, C. H., and O’Shea, M., 1976, Neuronal basis of a sensory analyser, the acridid movement detector system. III. J. Exp. Biol. 65: 617–625.
Gerschenfeld, H. M., 1973, Chemical transmission in invertebrate central nervous systems and neuromuscular junctions, Physiol. Rev. 53: 1–119.
Granger, N. A., and Sehnal, F., 1974, Regulation of larval corpora allata in Galleria mellonella, Nature 251: 415–417.
Holden, J. S., 1974, Glutamic acid and neuromuscular transmission in insects. Ph.D. dissertation, Dept. of Physiology and Biochemistry, Univ. of Southampton, England.
House, C. R., Ginsborg, B. L., and Silinsky, E. M., 1973, Dopamine receptors in cockroach salivary gland cells, Nature, New Biol. 245: 63.
Hoyle, G., 1975, Evidence that insect dorsal unpaired median (DUM) neurons are octopaminergic, J. Exp. Zool. 193: 425–431.
Irving, S. N., Osborne, M. P., and Wilson, R. G., 1976, Virtual absence of L-glutamate from the haemoplasm of arthropod blood, Nature 263: 431–433.
Johnston, G. A. R., 1976, Physiologic pharmacology of GABA and its antagonists in the vertebrate nervous system, in: GABA in Nervous System Function ( E. Roberts, T. N. Chase and D. B. Tower, eds.), pp. 395–411, Raven Press, New York.
Johnston, G. A. R., Stephanson, A. L., and Twitchin, B., 1976, Uptake and release of nipecotic acid by rat brain slices, J. Neurochem. 26: 83–87.
Kerkut, G. A., and Walker, R. J., 1966, The effect of L-glutamate, acetylcholine and gamma-aminobutyric acid on the miniature end-plate potentials and contractures of the coxal muscles of the cockroach, Periplaneta Americana, Comp. Biochem. Physiol. 17: 435–454.
Lea, T. J., and Usherwood, P. N. R., 1973, The site of action of ibotenic acid and the identification of two populations of glutamate receptors on insect muscle fibers, Comp. Gen. Pharmacol. 4: 333–350.
McDonald, T. J., 1972, Free radical mechanism for phenylhydrazine action on the retractor unguis muscle of the grasshopper, Romalea microptera, Comp. Gen. Pharmacol. 3: 319–326.
McDonald, T. J., 1975, Neuromuscular pharmacology in insects, Ann. Rev. Ent. 20: 151–166.
Miller, P. L., 1974, Rhythmic activities and the insect nervous system, in: Experimental Analysis of Insect Behavior. pp. 114–138, Springer-Verlag, New York.
Miller, R., Leaf, G., and Usherwood, P. N. R., 1973, Blood glutamate in arthropods, Comp. Biochem. Physiol. 44A: 991–996.
Miller, T. A., 1975, Neurosecretion and the control of visceral organs in insects, Ann. Rev. Entomol. 20: 133–149.
Miller, T. A., 1976, Distinguishing between carbamate and organophosphate insecticide poisoning in house flies by symptomology, Pestic. Biochem. Physiol. 6: 307–319.
Miller, T., and Kennedy, J. M., 1972, Flight motor activity of house flies as affected by temperature and insecticides, Pestic. Biochem. Physiol. 2: 206.
Miller, T., and James, J., 1976, Chemical sensitivity of the hyperneural nerve-muscle preparation of the American cockroach, J. Insect Physiol. 22: 981–988.
Mulloney, B., 1976, Control of flight and related behaviour by the central nervous systems of insects, in: Insect Flight ( R. C. Rainey, ed.), Wiley, New York.
Murdock, L. L., and Koidl, B., 1972a, Limited permeability and metabolism of L-glutamate in the locust gut wall, J. Exp. Biol. 56: 781–794.
Murdock, L. L., and Koidl, B., 1972b, Blood metabolites after intestinal absorption of amino acids in locusts, J. Exp. Biol. 56: 795–808.
Murdock, L. L., and Chapman, G. V., 1974, L-glutamate in arthropod blood plasma: physiological implications, J. Exp. Biol. 63: 783–794.
Neal, H., 1975a, Effects of L-glutamate and other drugs on some membrane properties of muscle fibers of Diptera, J. Insect Physiol. 21: 1771–1778.
Neal, H., 1975b, Neuromuscular junctions and L-glutamate-sensitive sites in the fleshfly, Sarcophaga bullata, J. Insect Physiol. 21: 1945–1951.
Oertel, D., and Case, J. F., 1976, Neural excitation of the larval firefly photocyte: slow depolarization possibly mediated by a cyclic nucleotide, J. Exp. Biol. 65: 213–227.
Osborne, N. N., and Neuhoff, V., 1974, Amino acid and serotonin content in the nervous system, muscle and blood of the cock-roach, Periplaneta americana, Brain Res. 80: 251–264.
Robertson, H. T., and Juorio, A. V., 1976, Octopamine and some related noncatecholic amines in invertebrate nervous systems, Int. Rev. Neurobiol. 19: 173–224.
Salpeter, M. M., and Faeder, I. R., 1971, The role of sheath cells in glutamate uptake by insect nerve-muscle preparations, Progr. Brain Res. 34: 103–114.
Sehnal, F., and Granger, N. A., 1975, Control of corpora allata function in larvae of Galleria mellonella, Biol. Bull. 148: 106–116.
Shinozaki, H., and Shibuya, I., 1974, A new potent excitant, quisqualic acid: effects on crayfish neuromuscular junction, Neupopharmacol. 13 (7): 665–672.
Smyth, T., Greer, M. H., and Griffiths, D. J. G., 1973, Insect neuromuscular synapses, Am. Zool. 13: 315–319.
Starratt, A. N., and Brown, B. E., 1975, Structure of the pentapeptide proctolin, a proposed neurotransmitter in insects, Life Sci. 17: 1253–1256.
Stevens, T. M., 1961, Free amino acids in the hemolymph of the American cockroach, Periplaneta amevicana L., Comp. Biochem. Physiol. 3: 304–309.
Takeuchi, A., and Onodera, K., 1975, Effects of kainic acid on the glutamate receptors of the crayfish muscle, Neuropharmacol. 14: 619–625.
Usherwood, P. N. R., 1974, Nerve-muscle transmission, in: Insect Neurobiology ( J. E. Treherne, ed.), pp. 245–305, Amsterdam, North Holland.
Usherwood, P. N. R., and Machili, P., 1968, Pharmacological properties of excitatory neuromuscular synapses in the locust, J. Exp. Biol. 49: 341–361.
Usherwood, P. N. R., and Cull-Candy, S. G., 1975, Pharmacology of somatic nerve-muscle synapses, in: Inseot Muscle ( P. N. R. Usherwood, ed.), Academic Press, New York.
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Miller, T.A. (1978). The Insect Neuromuscular System as a Site of Insecticide Action. In: Shankland, D.L., Hollingworth, R.M., Smyth, T. (eds) Pesticide and Venom Neurotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8834-4_8
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DOI: https://doi.org/10.1007/978-1-4615-8834-4_8
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