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The Influence of Cathepsin D Inhibitors (Pepstatin and Anticatheptic Antibodies) on Serum Cathepsin and Lysozyme Activity of60 Co Irradiated Animals

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Intracellular Protein Catabolism II

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Summary

In lethally irradiated (60Co) chickens and rabbits serum lysozyme levels were found to decrease gradually down to undetectable values. Serum catheptic activity increased sharply in chickens after ionizing irradiation and then remained at normal or slightly elevated values. Changes in activities of both studied lysosomal enzymes observed after ionizing irradiation, could be compensated to a certain extent by application of cathepsin D inhibitors — pepstatin and particularly anticatheptic immunoglobulin G.

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Authors and Affiliations

  1. Research Laboratory of Immunology, Department of Medical Microbiology and Immunology, Faculty of Medicine, Comenius University, Bratislava, ČSSR

    Jan Štefanovič, Miroslav Ferenčik & Olga Absolonova

Authors
  1. Jan Štefanovič
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  2. Miroslav Ferenčik
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  3. Olga Absolonova
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Editor information

Editors and Affiliations

  1. Department of Biochemistry J. Stefan Institute, University of Ljubljana, Ljubljana, Yugoslavia

    Vito Turk

  2. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, USA

    Neville Marks

  3. Strangeways Research Laboratory, Cambridge, C BI 4RN, England

    Alan J. Barrett

  4. Department of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Florida, USA

    J. Frederick Woessner

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© 1977 J. Stefan Institute, Ljubljana, Yugoslavia

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Štefanovič, J., Ferenčik, M., Absolonova, O. (1977). The Influence of Cathepsin D Inhibitors (Pepstatin and Anticatheptic Antibodies) on Serum Cathepsin and Lysozyme Activity of60 Co Irradiated Animals. In: Turk, V., Marks, N., Barrett, A.J., Woessner, J.F. (eds) Intracellular Protein Catabolism II. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8813-9_34

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  • DOI: https://doi.org/10.1007/978-1-4615-8813-9_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8815-3

  • Online ISBN: 978-1-4615-8813-9

  • eBook Packages: Springer Book Archive

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