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Purification and Some Properties of Native and Immobilized Cathepsin D

  • Chapter
Intracellular Protein Catabolism II

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Abstract

Cathepsin D (E.C. 3.4.23.5) is a carboxyl proteinase existing intracellularly in many animal tissues and is considered to be one of the major enzymes in lysosornes, responsible for protein breakdown within the cell. It has been suggested that cathepsin D plays an important role in muscular dystrophy (1), and in the pathology of connective tissue diseases, particularly rheumatoid arthritis (2). This enzyme is responsible for the major part of the breakdown of proteoglycans in cartilage degradation (3,4), as well as for the autolytic degradation of cartilage (5,6). Cathepsin D could be also responsible for the breakdown of basic myelin protein forming erctphalytogenic fragments (7). Finally, this enzyme may play a significant role in cardiac pathology (8) and tumour growth process (9).

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Authors and Affiliations

  1. Department of Biochemistry, J. Stefan Institute, University of Ljubljana, Ljubljana, Yugoslavia

    V. Turk, I. Urh, I. Kregar, J. Babnik, F. Gubenšek & R. Smith

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  1. V. Turk
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  2. I. Urh
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  3. I. Kregar
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  4. J. Babnik
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  5. F. Gubenšek
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  6. R. Smith
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Editor information

Editors and Affiliations

  1. Department of Biochemistry J. Stefan Institute, University of Ljubljana, Ljubljana, Yugoslavia

    Vito Turk

  2. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, USA

    Neville Marks

  3. Strangeways Research Laboratory, Cambridge, C BI 4RN, England

    Alan J. Barrett

  4. Department of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Florida, USA

    J. Frederick Woessner

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© 1977 J. Stefan Institute, Ljubljana, Yugoslavia

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Turk, V., Urh, I., Kregar, I., Babnik, J., Gubenšek, F., Smith, R. (1977). Purification and Some Properties of Native and Immobilized Cathepsin D. In: Turk, V., Marks, N., Barrett, A.J., Woessner, J.F. (eds) Intracellular Protein Catabolism II. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8813-9_30

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  • DOI: https://doi.org/10.1007/978-1-4615-8813-9_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8815-3

  • Online ISBN: 978-1-4615-8813-9

  • eBook Packages: Springer Book Archive

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