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Neuromuscular Transmission—Presynaptic Factors

  • Chapter
The Peripheral Nervous System

Abstract

There is an enormous body of evidence indicating that ACh is synthesized and stored in, and released from, motor nerve terminals. Release of ACh from nerve terminals occurs spontaneously in multimolecular amounts (quanta) which can be detected by the resulting depolarization (m.e.p.p.) of the muscle membrane at the end plate. Nerve impulses accelerate quantal release. The quantal nature of release is currently thought to arise because ACh is stored in, and released from, the synaptic vesicles found in great number in nerve terminals (vesical hypothesis). Quantal release is then the release of the contents of vesicles into a synaptic cleft (reviewed by Martin, 1966; Hubbard, 1970, 1973).

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  1. Department of Physiology, Medical School, University of Otago, Dunedin, New Zealand

    John I. Hubbard

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  1. Department of Physiology, University of Otago, Dunedin, New Zealand

    John I. Hubbard

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© 1974 Plenum Press, New York

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Hubbard, J.I. (1974). Neuromuscular Transmission—Presynaptic Factors. In: Hubbard, J.I. (eds) The Peripheral Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8699-9_7

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  • DOI: https://doi.org/10.1007/978-1-4615-8699-9_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-8701-9

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