Abstract
Understanding of transmission at the autonomic neuroeffector junction has lagged behind knowledge of transmission at the skeletal neuromuscular junction, largely because the relationship of the complex “autonomic ground plexuse” (Hillarp, 1949) to effector cells was difficult to determine with light microscopy and whole organ pharmacology. Some valiant attempts to resolve autonomic transmission mechanisms were made on the basis of external electrode recording (e.g., Eccles and Magladery, 1937; Bozler, 1948; Rosenblueth, 1950), but it was not until membrane potential changes were recorded in single cells during stimulation of autonomic nerves (Burnstock and Holman, 1960; see Holman, 1970), and the precise relationships of nerve fibers to single muscle cells were determined with the electron microscope (Caesar et al., 1957; see Burnstock, 1970), that there was a real opportunity to resolve the mechanism of autonomic neuromuscular transmission.
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Burnstock, G., Bell, C. (1974). Peripheral Autonomic Transmission. In: Hubbard, J.I. (eds) The Peripheral Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8699-9_12
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