Abstract
By the time phosphamidon was developed as an insecticide, it was generally recognized that organophosphorus compounds are subjected to chemical and/or biochemical (enzymatic) transformation processes in plant, mammalian, and insect tissues (O’Brien 1960, Heath 1961). Biologically speaking, these transformation processes represent either activation or degradation. With regard to organophosphate insecticides, activation means conversion of the parent compound to a metabolite with increased anticholinesterase activity, whereas degradation means conversion to metabolites which no longer inhibit cholinesterases, or which do so to a much smaller degree (O’Brien 1967, Fukuto and Metcalf 1969). The toxicological significance of organophosphorus metabolites normally parallels their anticholinesterase activity, although this may be masked or offset by the ease with which a particular anticholinesterase agent is degraded within the animal body.
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Geissbühler, H., Voss, G., Anliker, R. (1971). The metabolism of phosphamidon in plants and animals. In: Gunther, F.A., Gunther, J.D. (eds) Phosphamidon. Residue Reviews / Rückstands-Berichte, vol 37. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-8473-5_4
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DOI: https://doi.org/10.1007/978-1-4615-8473-5_4
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