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On the problem of the harmful effect of DDT and its mechanism of action

  • Yu. S. Kagan
  • S. I. Fudel-Ossipova
  • B. J. Khaikina
  • U. A. Kuzminskaya
  • S. D. Kouton
Conference paper
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 27)

Abstract

Potential hazards to public health from the pesticides are associated with their ability to accumulate in nature and in human organisms.

Keywords

Adipose Tissue Clinical Aspect Human Organism Microsomal Enzyme American Cockroach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Agosin, M., L. Aravena, and A. Neghme: Enhanced protein synthesis in Triatoma infestam treated with DDT. Expt. Parasitol. 16, 318 (1965).CrossRefGoogle Scholar
  2. Alov, I. A., A. I. Braude, and I. E. Asinz: Principles of cell functional morphology. Ed. “Meditsina,” Moscow (1966).Google Scholar
  3. Anderson, A. D., R. B. March, and R. L. Metcalf: Inhibition of the succinoxi-dase system of susceptible and resistant houseflies to DDT and its related compounds. Ann. Entomol. Soc. Amer. 47, 595 (1954).Google Scholar
  4. Anonymous: Use of pesticides. A report by the President’s Science Advisory Committee. Residue Reviews 6, 1 (1964).Google Scholar
  5. Atabaev, Sh. T.: DDT and hexachlorocyclohexane in soil and the hygienic evaluation of potatoes raised in it. Hygiene and Toxicology of Pesticides and Clinical Aspects of Poisoning 3, 149 (1965).Google Scholar
  6. Avi-Dor, V., and O. Gonda: Studies on the adenosine triphosphate-phosphate exchange and the hydrolysis of adenosine triphosphate catalysed by a particulate fraction from the mosquito. Biochem. J. 72, 8 (1959).PubMedGoogle Scholar
  7. Babers, F. H., and J. J. Pratt: Resistance of insects to insecticides. The metabolism of the insecticide DDT. J. Econ. Entomol. 46, 977 (1953).Google Scholar
  8. Barnes, Y. M.: Fight with hazards to health connected with the application of pesticides. In: “Success in the Field of Fighting Plant Pests.” Moscow (1960).Google Scholar
  9. Behrbohm, P.: Allergia u. Asthma 8, 4/5, 237 (1962).Google Scholar
  10. Benton, A. H.: Effect on wildlife of DDT used for control of Dutch elm disease. J. Wildlife Management 15, 1 (1951).CrossRefGoogle Scholar
  11. Bing, R. J., B. McNamara, and J. Barol: Studies on the pharmacology of DDT (2,2-bis-parachlorophenyl-1,1,1-trichlorethane). The chronic toxicity of DDT in the dog. Johns Hopkins Hosp. Bull. 78, 5 and 308 (1946).Google Scholar
  12. Bodazhkova, K. N., N. M. Zhukova, and N. N. Mamaeva: On the question of the complex action of pesticides used for the treatment of fruit trees. In: Hygiene and Toxicology of Pesticides and Clinical Aspects of Poisoning 3, 176 (1965).Google Scholar
  13. Boidak, R. I.: A case of acute anemia in consequence of the poisoning with the DDT preparation. Col. Sci. Trans. Vinitsa State Med. Inst. 16, 93 (1957).Google Scholar
  14. Boldyrev, T. E. and V. I. Vashkov: On toxic DDT properties. Militaey Med. J. 4, 43 (1947).Google Scholar
  15. Boswell, V. R.: Effects of certain insecticides in soil on crop plants. U.S. Department of Agriculture Tech. Bull. 1121 (1951).Google Scholar
  16. Bromeley, R. B., and P. Bard: Tremor and changes in reflex status produced by DDT in decerebrate deeerebrate-decerebellate and spinal animals. Bull. J. Hopkins Hosp. 84, 414 (1949).Google Scholar
  17. Burkatskaya, E. N., and G. A. Voitenko: M.P.C. (maximum permissible concentration) a DDT basing in the air of workers’ premises. J. Hyg. and Sanit. 11, 36 (1963).Google Scholar
  18. Burkatskaya, E. N., and G. A. Voitenko, and E. P. Krasntok: Working conditions and state of health of theGoogle Scholar
  19. workers in DDT-producing plant. J. Hygiene and Sanit. 9, 24 (1961).Google Scholar
  20. Burstein, A. L.: The content of DDT in food products, organization measures on the supervision of the storing and application of pesticides. In: Hygiene and Toxicology of Pesticides and Clinical Aspects of Poisoning 3, 157 (1965).Google Scholar
  21. Butts, J. S., S. C. Chang, B. E. Christensen, and C. H. Wang: DDT detoxification product in American cockroaches. Science 117, 699 (1953).PubMedCrossRefGoogle Scholar
  22. Carey, R. J., E. M. Downer, and F. B. Toomey: Morphological effect of DDT on nerve endings, neurosomes and fiber types in voluntary muscles. Proc. Soc. Expt. Biol. Med. 62, 76 (1946).Google Scholar
  23. Cavandan, P., and H. Poussel: Le mécanisme de l’action insecticide du dichloro-diphenyl-trichlorethane (DDT) et la régie thérmodynamique des narcotiques indifférents. Compt. rendu Acad. Sci. Paris 224, 683 (1947).Google Scholar
  24. Chisholm R. D., L. K. Koblitzky, J. E. Fahey, and W. E. Westlake: DDT residues in soil. J. Econ. Entomol. 43, 6 (1951).Google Scholar
  25. Colhoun, E. H.: Acetylcholine in Periplaneta americana L. III. Acetylcholine in roaches treated with tetraethyl pyrophosphate and 2.2-bis(p-chlorophenyl)-1.1.1-trichloroethane. Canad. J. Biochem. Physiol. 37, 259 (1959).CrossRefGoogle Scholar
  26. Conney, A. H., R. M. Welch, R. Kuntzman, and J. Burns: Effects of pesticides on drug and steroid metabolism. Clin. Pharmacol. Therapy 8, 2 (1967).Google Scholar
  27. Crescitelli, F., and A. Gilman: Electrical manifestations of the cerebellum and cerebral cortex following DDT administration on cats and monkeys. Amer. J. Physiol. 147, 127 (1946).PubMedGoogle Scholar
  28. Dale, W. E., M. F. Copeland, and W. J. Hayes: Chlorinated insecticides in body fat of people in India. Bull. World Health Org. 33, 471 (1965).PubMedGoogle Scholar
  29. Dale, W. E., M. F. Copeland, G. W. Pearce, and J. N. Miles: Concentration of o, p’-DDT in rat brain at various intervals after dosing. Arch. Internat. Pharmacodyn. Therap. 162, 40 (1966).Google Scholar
  30. Dale, W. E., T. B. Gaines, W. J. Hayes, and G. Pearce: Poisoning by DDT: Relation between clinical signs and concentration in rat brain. Science 142, 1474 (1963).PubMedCrossRefGoogle Scholar
  31. Desi, J., J. Farkas, and F. Kemeny: Changes of central nervous function in response to DDT administration. Acta Physiol. Acad. Sci. Hung. 30, 275 (1966).PubMedGoogle Scholar
  32. Domenjoz, R.: Experimentelle Erfahrungen mit einem neuen Insecticid (Nicocid Geygy); ein Beitrag zur Theorie der Kontaktgiftwirkung. Schweiz, med. Wschr. 74, 952 (1944).Google Scholar
  33. Dresden, D.: Site of action of DDT and cause of death after acute DDT poisoning. Nature 162, 4130 (1948).CrossRefGoogle Scholar
  34. Dresden, D.: Physiological investigations into the action of DDT 2.2-bis(p-chlorophenyl)-1.1.1-trichlorethane, p. 114. Arnhem: G. W. van der Wiel & Co. (1949).Google Scholar
  35. Durham, W. F., and J. F. Armstrong: The content of insecticides in rations and in fatty tissues of the Alaska population. Science 134, 1880 (1961).PubMedCrossRefGoogle Scholar
  36. Durham, W. F., and J. F. Armstrong, and G. E. Quinby: DDT and DDE content of complete prepared meals. Toxicol. Applied Pharmacol. 7, 3 and 482 (1965).Google Scholar
  37. Durham, W. F., P. Ortega, and W. Y. Hayes: Effect of various DDT quantities in the Rhesus-monkey ration on the function of the liver, morphology of the cell and the DDT storage in the organism of animals. Arch. Int. Pharmacol. Therap. 141, 14 (1963).Google Scholar
  38. Efitfeyeva, A. I.: One of the indicators of the muscular cell reaction on the organism poisoned with DDT and Sevin. Coll. Hygiene Toxicol. Ed. “Zdorovye,” Kiev 5, 200 (1967).Google Scholar
  39. Eyzaguirreg, A. B., and J. L. Lilienthal: Neurotrophic effects of pentamethylen ethazol (Metrazol) and 2.2-bis-p-chlorophenyl-1.1.1-trichloroethane (DDT) on mammalian neuromuscular function. Proc. Soc. Expt. Biol. Med. 70 (1), 272 (1949).Google Scholar
  40. Faur, N., and T. Kemen: Effect of chronic introduction into the body of small quantities of DDT on the blood picture of BALB/c mice. Hygiena Sanitär. 2, 86 (1968).Google Scholar
  41. Fedorenko, A. P.: Negative effect of various chemical preparations on useful warm-blooded animals. In: “Pesticides and Fauna,” Ed. “Nauka,” p. 37 (1967).Google Scholar
  42. Fleming, N. E., and A. Hawley: A large scale test with DDT to control the Japanese beetle. J. Econ. Entomol. 43, 1 (1950).Google Scholar
  43. Frankone, M. P., F. N. Nariani, and C. Demark: Pesticides. Rev. Assoc. Med. Org. 65, 19 (1951).Google Scholar
  44. Frazer, A. C.: Pesticides. Ann. Review Pharmacol. 7, 319 (1967).Google Scholar
  45. Frieberg, L., and B. Martensson: Pesticides. Arch. Intern. Med. Occupat. Med. 8, 2 and 166 (1955).Google Scholar
  46. Fudel-Ossepova, S. I.: On some approaches to the study of the effect of toxic substances on the organism. Coll. Hygiene Toxicol. Pesticides and Clinical Aspects of Poisoning, Ed. “Zdorovye,” Kiev, p. 137 (1967).Google Scholar
  47. Gahan, I. B., H. G. Wilson, and W. C. Meduffie: Dry sugar baits for the annihilation of houseflies. J. Agr. Food Chem. 2, 245 (1954).CrossRefGoogle Scholar
  48. Genderen, H. V.: The toxicology of the chlorinated hydrocarbon insecticides. Meded. Landbauwhogeschool en Opzoekingsstat. Staat Gent 30, 1321 (1965).Google Scholar
  49. Gonda O., A. Kaluszyner, and V. Avi-Dor: Effect of 1:1:1-tri-ehloro-2:2 -di(p-chlorophenyl) ethane (DDT) and related compounds on the adenosine tri-phosphate-phosphate exchange catalyzed by a particulate fraction from mosquito. Biochem. J. 73, 583 (1959).PubMedGoogle Scholar
  50. Gracheva, G. V.: On residual pesticide quantities in food products. In Hygiene Toxicol. Pesticides and Clinical Aspects of Poisoning, Ed. “Zdorovye,” Kiev, p. 133 (1965).Google Scholar
  51. Green, D. E.: On biological membranes. In: Molecular Biology, Problems and Perspectives, Ed. “Nauka,” Moscow (1964).Google Scholar
  52. Green, D. E., and A. Tzagoloff: Role of lipids in the structure and function of biological membranes. J. Lipid Research 7, 587 (1966).Google Scholar
  53. Harlow, R. A.: The action of drugs on the nervous system of the locust (Locusta migratoria). Ann. Applied. Biol. 46, 55 (1958).CrossRefGoogle Scholar
  54. Hart, L. J., and J. R. Fouts: Effects of acute and chronic DDT administration on hepatic microsomal drug metabolism in the rat. Proc. Soc. Expt. Biol. 144, 388 (1963).Google Scholar
  55. Hayes, W. Y.: Pharmacology and toxicology of DDT; see Müller, P., Das Insektizid Dichlordiphenyltrichlorethan und seine Bedeutung. Basel-Stuttgart II, 11 (1959).Google Scholar
  56. Hayes, W. Y.: Review on metabolism of chlorinated hydrocarbons especially in mammals. Ann. Review Pharmacol. 5, 27 (1965).CrossRefGoogle Scholar
  57. Hayes, W. J.: The go-dose and chronicity factor as measures of toxicity. Toxicol. Applied Pharmacol. 10, 406 (1967).Google Scholar
  58. Hayes, W. J., and W. Dale: Insecticide storage in the organism of the residents of France. Nature 199, 1189 (1963).PubMedCrossRefGoogle Scholar
  59. Hayes, W. J., W. F. Durham, and C. Cuets: Effect of some chlorophenoethane (DDT) doses on man at their multiple ingestion. J. Amer. Med. Assoc. 1, 890 (1956).CrossRefGoogle Scholar
  60. Hayes, W. J., G. E. Quinby, K. C. Walker, J. W. Elliot, and W. M. Upholt: DDT and DDE storage in humans exposed to DDT. A.M.S.C. Arch. Ind. Health 18, 398 (1958).Google Scholar
  61. Haymaker, W., A. M. Ginzer, and R. L. Ferguson: The toxic effects of prolonged ingestion of DDT on dogs with special reference to lesions in the brain. Amer. J. Med. Sci. 212, 423 (1946).PubMedCrossRefGoogle Scholar
  62. Hoffman, W. S., V. Fishbeim, and M. Andelman: Pesticide content in the fatty tissue of man. Arch. Environ. Health 9, 3 and 387 (1964).Google Scholar
  63. Holden, A. B.: A study of the absorption of C14-labelled DDT from water by fish. Ann. Applied Biol. 50, 467 (1962).CrossRefGoogle Scholar
  64. Ilinskaya, N. B.: Mechanism of DDT effect on insects. U.S.S.R. Acad. Sci., Moscow (1961).Google Scholar
  65. Jefferies, D. J., and C. U. Walker: Uptake of p-p’-DDT and its post-mortem breakdown in the avian liver. Nature 212, 533 (1966).CrossRefGoogle Scholar
  66. Johnston, C. D.: The in vitro effect of DDT and related compounds on the succinoxidase system of rat heart. Arch. Biochem. Biophys. 31, 375 (1951).PubMedCrossRefGoogle Scholar
  67. Kagan, Yu. S., G. A. Rodionov, E. M. Semencheva, A. M. Lukaneva, L. Ya. Voronina, L. S. Velichko, Medved, L. I, Yu. S. Kagan, and B. I. Khaikina: Hazards of the appearance of pathology of chemical etiology and criteria of hygienic evaluation of chemical substances. In: “General Questions of Industrial Toxicology,” Moscow, p. 11 (1967).Google Scholar
  68. Kailin, E., and A. Hastings: Cerebral disturbances from small amounts of DDT. Ann. D.C. 35, 519 (1966).Google Scholar
  69. Kaprinski, B.: Red purpura after using DDT. J. Pediatrics 37, 1 (1950).CrossRefGoogle Scholar
  70. Kearns, C. N.: The enzymatic detoxication of DDT. Origins of resistance to toxic agents. Proceed. Sympos., p. 148 New York: Academic Press (1955).Google Scholar
  71. Kedrova, E. P.: On toxic properties of DDT. Nutrition Problems 12, 2 and 62 (1953).Google Scholar
  72. Khaikina, B. J., and U. A. Kuzminskaya: Some indices of energetic metabolism in the tissues of warm-blooded animals under exposure to pesticides. XIth Internat. Congress Prophyl. Med. Soc. Hyg. p. 40, Sofia-Varna (1966).Google Scholar
  73. Khaikina, B. J., and J. A. Kuzminskaya: New material on the biochemical mechanism of action of some pesticides. Coll. Hygiene Toxicol. Ed. “Zdorovye,” Kiev 5, 217 (1967).Google Scholar
  74. Khaikina, B. J., and A. Kh. Ostrovskaya: DDT and Sevin effect on the mechanico-chemical mitochondria activity. Coll. Hygiene Toxicol. Ed. “Zdorovye,” Kiev 5, 243 (1967).Google Scholar
  75. Kinoshite, F. K., J. P. Frawley, and K. P. Du Bois: Quantitative measurement of induction of hepatic microsomal enzymes by various dietary levels of DDT and toxaphene in rats. Toxicol. Applied Pharmacol. 9, 505 (1966).CrossRefGoogle Scholar
  76. Krasnyuk, E. P.: State of health of workers engaged in DDT plants. In: Hygiene, toxicology and clinical aspects of insectofungicides, Moscow p. 350 (1959).Google Scholar
  77. Krasnyuk, E. P.: Pathology of the liver in workers employed in DDT production. Essay on Candidate Dissert., Kiev (1961).Google Scholar
  78. Krasnyuk, E. P.: On the combined effect of different insecticides on the digestion organs. In: Hygiene and toxicology of pesticides and clinical aspects of poisoning 3, 532 (1965).Google Scholar
  79. Krasnyuk, E. P., L. S. Oginskaya, and F. A. Onikienko: Pathology of the liver in workers contacting DDT. Vrachebnoye Delo I, 92 (1965).Google Scholar
  80. Kozhanchikov, I. V.: On the specific metabolism resistance of insects to DDT. U.S.S.R. Acad. Sci. 58, 345 (1947).Google Scholar
  81. Kozhanchikov, I. V.: On the comprehension of the physiological DDT effect on insects. Coll. Trans. Inst. Applied Zool. Phytopathol. 2, 3 (1953).Google Scholar
  82. Kovtun, S. D., and A. J. Sokur: Effect of DDT on the content of sodium and potassium in the skeletal muscles and blood serum of white rats. In: Hygiene and toxicol. Pesticides and clinical aspects of poisoning 5, 223 (1967).Google Scholar
  83. Kresbach, H.: Schwere DDT Dermatitis mit erheblicher Störung des Allgemeinbefindens und Symptomen von Seiten innerer Organe. Wien. Hin. Wschr. 27, 559 (1953).Google Scholar
  84. Lachinova, R. I.: DDT effect on the mitochondria of flies in standard and at developing resistance to DDT. Mitochondria: Biochemistry and morphology, Ed. “Nauka,” Moscow (1967).Google Scholar
  85. Laug, E. P., F. M. Kunze, and E. S. Prickett: DDT in adipose tissue and in milk of humans. Arch. Ind. Hygiene Occupat. Med. 3, 245 (1951).Google Scholar
  86. Läuger, H. H., H. Martin, and P. Müller: Über Konstitution und toxische Wirkung von natürlichen und neuen synthetischen insektentötenden Stoffen. Acta Helv. Chim. 27, 892 (1944).CrossRefGoogle Scholar
  87. Lazarev, N. V.: Problems of geohygiene and their connection with the task of investigating new insectifungicides and herbicides. In: Hygiene, toxicology and clinical aspects of new insectofungicides 22, 331 (1959).Google Scholar
  88. Lehninger, A. L.: Transformation of respiration energy. In: Modern problems of biophysics 1, 177 (1961).Google Scholar
  89. Lehninger, A. L.: The mitochondrion. Molecular basis of structure and function. Ed. “Mir,” Moscow (1966).Google Scholar
  90. Lelyukh, V. M., and V. I. Malyuk: Appearance of bronchial asthma at prolonged DDT influence. In: Hygiene and toxicology of pesticides and clinical aspects of poisoning 4, 330 (1966).Google Scholar
  91. Lewis, S. E.: Acetylcholine in blowflies. Nature 172, 1004 (1953).PubMedCrossRefGoogle Scholar
  92. Lichtenstein, E. P., and K. R. Schulz: Resistance of some chloroorganic insecticides depending on the kind of soil, dose, and temperature. In: New chemical means of plant protection, Moscow, p. 213 (1960).Google Scholar
  93. Ludwig, D. M., and M. Barsaa: Effects of added substrates and inhibitors on homogenate respiration during the metamorphosis of the mealworm: Tenebrio molitor. L. Ann. Entomol. Soc. Amer. 50, 128 (1957).Google Scholar
  94. Ludwig, D. M., and M. Barsaa, and C. Cali: The effect of DDT on the activity of cytochrome-oxidase. Ann. Entomol. Soc. Amer. 48, 165, (1955).Google Scholar
  95. Lukaneva, A. M.: Quoted from L. I. Medved et al. In: General questions of industrial toxicol. Moscow II (1967).Google Scholar
  96. McCully, K. A., D. A. Villeneuve, W-E. McKinley, U. E. Phillips, and M. Hmmoglou: Metabolism and storage of DDT in beef cattle. J. Assoc. Official Anal. Chemists 49, 966 (1966).Google Scholar
  97. Mater-Bode, H.: Pflanzenschutzmittel-Rückstände. Insektizide. Stuttgart: Verlag Eugen Ulmer (1965).Google Scholar
  98. Makovskaya, E. I.: Pathological anatomy of poisoning with pesticides. Ed. “Medicine,” Moscow (1967).Google Scholar
  99. Makovskaya, E. I., and C. G. Serebryanaya: On some morphological and histological alterations of DDT poisoning. Physiol. J. Acad. Sci. Ukrainian SSR VII, 2 and 251 (1961).Google Scholar
  100. Malyuk, V. I.: On allergic diseases of chemical etiology. In: Hygiene and toxicology of pesticides and clinical aspects of poisoning 4, 42 (1966).Google Scholar
  101. Matsumura, F., and R. D. O’Brien: Absorption and binding of a DDT by the central nervous system of the American cockroach. J. Agr. Food Chem. 14, 36 (1966 a).CrossRefGoogle Scholar
  102. Matsumura, F., and R. D. O’Brien: Interactions of DDT with a component of American cockroach nerve. J. Agr. Food Chem. 14, 39 (1966 b).CrossRefGoogle Scholar
  103. Matusevitch, T. I., K. V. Sorokina, and A. I. Lebedeva: Content of residual pesticide quantities in food products. In: Hygiene and toxicology of pesticides and clinical aspects of poisoning 3, 141 (1965).Google Scholar
  104. Medved, L. I.: Results and further task of scientific investigation on the hygienic and toxic evaluation of insectifungicides. In: Hygiene and toxicology and clinical aspects of new insectifungicides, Ed. “Mediz,” Moscow (1959).Google Scholar
  105. Medved, L. I.: Theoretical problems of hygiene and toxicology in view of the chemicalization of agriculture. In: Hygiene and toxicology of pesticides and clinical aspects of poisoning 3, 8 (1965).Google Scholar
  106. Medved, L. I., Ju. S. Kagan, B. J. Khaikina, V. S. Buryi, I. A. Belonozhko, and O. V. Stankevich: Hazards of pathology development and criteria of the hygienic evaluation of chemical substances. In: General questions of industrial toxicology, Moscow II (1967).Google Scholar
  107. Melnikov, N. N.: Persistence and insecticide residual quantities. Chem. in Agr. 22, 111 (1965).Google Scholar
  108. Miskus, R.: DDT. In: Methods of pesticide analysis. Ed. “Chemistry,” Moscow, p. 305 (1967).Google Scholar
  109. Mitchell, R. F., H. P. Blagrough, and R. C. Van Effen: Effect of DDT upon survival and growth of nestling songbirds. J. Wildlife Management 17, 1 (1953).CrossRefGoogle Scholar
  110. Miyake, S. S., C. Kearns, and H. Lipke: Distribution of DDT-dehydrochlorinase in various tissues of DDT-resistant house flies. J. Econ. Entomol. 50, 359 (1957).Google Scholar
  111. Morello, A.: Induction of DDT-metabolizing enzymes in microsomes of rat liver after administration of DDT. Canad. J. Biochem. 48, 1289 (1965).Google Scholar
  112. Morrison, P., and A. Brown: The effect of insecticides on cytochrome oxidase obtained from the American cockroach. J. Econ. Entomol. 47, 723 (1954).Google Scholar
  113. Mullins, J. J.: Structure toxicity in hexachlorocyclohexane isomers. Science 122, 118 (1955).PubMedCrossRefGoogle Scholar
  114. Nachmanson, D.: Investigation perspectives of molecular principles of the nerve activity. Coll.: Molecular biology, Ed. “Nauka,” Moscow, p. 282 (1964).Google Scholar
  115. Narahashi, T., and T. Yamasaki: Mechanism of the after-potential production in the giant axons of the cockroach. J. Physiol. 151, 75 (1960 a).PubMedGoogle Scholar
  116. Narahashi, T., and T. Yamasaki: Mechanism of increase in negative after-potential by Dicophanum (DDT) in the giant axones of the cockroach. J. Physiol. 152, 122 (1960 b).PubMedGoogle Scholar
  117. Negherbon, W. O.: Toxic reference book, vol. III. Insecticides. Philadelphia-London: Saunders (1959).Google Scholar
  118. Neufach, S. A.: Dynamic structure of intracellular membranes and regulation of activity of the glycolysis ferments in the cell. In: Mechanism and kinetics of the fermentation catalysis, Ed. “Nauka,” Moscow, p. 272 (1964).Google Scholar
  119. Neufach, S. A., Y. S. Gaizkhoki, G. B. Kasakova, M. P. Melnikova, and V. S. Turowsky: On the chemical nature of the mitochondrial factor accelerating the glycolysis. Report U.S.S.R. Acad. Sci. 144, 449 (1962).Google Scholar
  120. Neufach, S. A., and V. S. Repin: The mitochondria albuminous factor accelerating the glycolysis. Problem of Med. Chem. 3, 324 (1963).Google Scholar
  121. O’Brien, R. D.: Mode of action of insecticides. Ann. Rev. Entomol. 11, 369 (1966).CrossRefGoogle Scholar
  122. O’Brien, R. D., and F. Matsumura: DDT — A new hypothesis of mode of action. Science 146, 657 (1964).PubMedCrossRefGoogle Scholar
  123. Ortega, P.: Light and electron microscopy of DDT poisoning in the rat liver. Labor. Investig. 15, 657 (1966).Google Scholar
  124. Ortelle, M. F.: Investigation of people who owing to their occupation were exposed to prolonged influence of DDT. Arch. Ind. Health 18, 433 (1958).Google Scholar
  125. Ostroukhova, V. A.: Effect of oxygen on the intoxication course caused by DDT. Coll.: Hygiene and physiol. of labour, production toxicol., clinical aspects of professional diseases, Kiev 73, 17 (1963).Google Scholar
  126. Ostroukhova, V. A.: Dynamics of activity changes of oxidative enzymes and tissue respiration in animals at repeated administration of small DDT doses. Coll. Pharmacol. Toxicol. Kiev 152, 18 (1964).Google Scholar
  127. Ozburn, G. W., and F. O. Morrison: Development of DDT-tolerant strain of laboratory mice. Nature 196, 1009 (1962).PubMedCrossRefGoogle Scholar
  128. Palade, G. E.: Electron microscopy of cytoplasmic structures. In: Enzymes: Units of biological structure and function. N.Y. Acad. Sci. (1956).Google Scholar
  129. Pavlova, J. J.: Effect of DDT and sevin on the content of pyridine-nucleotides (NAD and NADP) in different fractions of the homogenates of the liver of white rats. Coll.: Hygiene and toxicol. mater, city sci. confer. young engineers-scientists, Kiev, Ed. “Zdorovye,” p. 235 (1967).Google Scholar
  130. Perry, A. S., and W. M. Hoskins: Detoxication of DDT as a factor in the resistance of houseflies. J. Econ. Entomol. 44, 850 (1951).Google Scholar
  131. Peterson, J. E., and W. H. Robinson: Metabolic products of p-p’-DDT in the rat. Toxicol. Applied Pharmacol. 6, 321 (1964).CrossRefGoogle Scholar
  132. Philips, F. S., and A. Gilman: Studies on the pharmacology of DDT (2,2-bis-parachlorphenyl-1:1:1-trichlorethane). 1. The acute toxicity of DDT following intravenous injection in mammals with observation on the treatment of acute DDT poisoning. J. Pharmacol. 86, 213 (1946).Google Scholar
  133. Pillai, M. K. K., Z. H. Abedi, and A. W. A. Brown: Warf-antiresistant compounds as synergists against DDT-resistant Aedes aegypti. Mosquito News 23, 112 (1963).Google Scholar
  134. Porter, C. C., and C. A. Stone: Biochemical mechanisms of drug action. Ann. Rev. Pharmacol. 7, 15 (1967).PubMedCrossRefGoogle Scholar
  135. Ptitsina, N. V., and L. V. Polischuk: Dynamics of DDT content alteration in apples treated with DDT preparation in the course of growing and getting ripe in the Crimean conditions. In: Hygiene and toxicology of pesticides, clinical aspects of poisoning 3, 143 (1965).Google Scholar
  136. Rappoport, M. B., and V. A. Ostroukhova: Pathological and other biochemical changes in the organism at the influence of DDT small doses. Coll.: Toxicology and pharmacology of pesticides and other chemical compounds 5, 131 (1967).Google Scholar
  137. Rappoport, M. B., S. I. Serebryanaya, E. I. Makovskaya, and P. A. Lyubenko: Some additions to the toxic DDT, DDD and Perthane characteristics, morphological and histological changes in the organism of animals due to their influence. Coll.: Hygiene and toxicology of pesticides, clinical aspects of poisoning 3, 352 (1965).Google Scholar
  138. Read, S. T., and W. P. Kinley: DDT and DDE content in man’s fatty tissue. Arch. Environ. Health 3, 209 (1961).PubMedGoogle Scholar
  139. Richards, A. G., and L. K. Cutcomp: Neuropathology in insects, J. New York Entomol. Soc. 53, 313 (1945).Google Scholar
  140. Robbins, C. S., P. F. Springer, and S. G. Webster: Effect of five-year DDT application on breeding bird population. J. Wildlife Management 15, 2 (1951).Google Scholar
  141. Roeder, R. D., and E. A. Weiant: The effect of DDT on sensory and motor structures in the cockroach leg. J. Cell Compar. Physiol. 32, 175 (1948).CrossRefGoogle Scholar
  142. Rybakova, M. N.: Comparative toxic effect of Sevin and DDT on the animal organism. Essay of Dissert., Moscow (1966 a).Google Scholar
  143. Rybakova, M. N.: Experimental materials on the comparative toxic effect of Sevin and DDT on some endocrine glands. 16th Session Nutr. Inst. vol. 2, p. 89. Ed. “Aleal U.S.S.R.” Moscow (1966 b).Google Scholar
  144. Sacktor, B.: A comparison of the cytochrome oxidase activity of two strains of houseflies. J. Econ. Entomol. 43, 832 (1950).Google Scholar
  145. Sacktor, B.: Some aspects of respiratory metabolism during metamorphosis of normal and DDT-resistant houseflies (Musca domestica). J. Biol. Bull. 100, 229 (1951).CrossRefGoogle Scholar
  146. Schalke, B.: Der Einfluß von Dichlor-diphenyl-trichlorethan (DDT) auf die Erregbarkeit der peripheren Muskulatur von Albinoratten. Acta Biol. Med. Germ. 10, 275 (1963).Google Scholar
  147. Schillinger, Ju. I.: Transition of DDT in cow’s milk treated with this preparation with the aim of controlling the skin gadfly. Problems of Nutrit. 12, 2 and 68 (1953).CrossRefGoogle Scholar
  148. Sent-Györgyi, A.: Bioenergetics. Moscow (1960).Google Scholar
  149. Serebtyanaya, S. G.: On the toxic effect pentachlorine (DDT). Pharmacol. Toxicol. 3, 38 (1950).Google Scholar
  150. Serebtyanaya, S. G.: Role of the nervous system in the development of intoxication under pentachlorine (DDT) influence. Problems of Physiol. 5, 113 (1953).Google Scholar
  151. Serebtyanaya, S. G.: Hygienic characteristics of food products obtained from plants treated with DDT. Hyg. and Sanit. 10, 29 (1956).Google Scholar
  152. Serebtyanaya, S. G.: Evaluation of chlororganic pesticides from the point of view of hygiene of nutrition. In: First union sci. confer, on hyg. and toxicol. of insectifungicides (Abstr. of Rept.) 5, 134 (1957).Google Scholar
  153. Serebtyanaya, S. G.: Evaluation of chlororganic pesticides from the point of view of new insectifungicides. In: Hygiene and toxicology clinical aspects of new insectifungicides, p. 131. Ed. “Mediz,” Moscow (1959).Google Scholar
  154. Serebtyanaya, S. G.: Toxic and hygienic characteristics of new chlororganic insecticides in food products influenced by them. Coll.: Hygiene and toxicology of new pesticides and clinical aspects of poisoning, p. 124. Moscow (1962).Google Scholar
  155. Serebtyanaya, S. G.: Histological alterations in animal organs at DDT influence and its analogues (DDT and Pethane). In: Hygiene and toxicology of labour, production toxicology, chemical aspects of occupational diseases, p. 69. Kiev (1963).Google Scholar
  156. Serebtyanaya, S. G.: Significance of the food products examination in preventive poisoning with poisonous chemicals. In: Hygiene and toxicology of pesticides and clinical aspects of poisoning 3, 123 (1965).Google Scholar
  157. Serebtyanaya, S. G., E. N. Burkatskaya, and Z. V. Ivanova: Secretion of DDT with the milk of cows treated with its preparations. Abstr. of Rept., Scient. Session of the Kiev Institute of Labour, Hygiene, and Professional Diseases, p. 15 (1949).Google Scholar
  158. Shapovalov, A. I.: Mechanism of effect of oppressed substances on the excited cell membrane. Trans. first symp. on question of general physiol. protoplasmic membranes and their functional role, p. 211. Acad. Sci. Ukr. S.S.R. (1957).Google Scholar
  159. Sjöstrand, F.: Morphology of regulated biological structures. Coll.: Functional cell morphology Al., p. 69 (1963).Google Scholar
  160. Smith, M. J., and B. F. Stohlman: The pharmacologic action of 2,2-bis (p-chlorophenyl) -1:1:1 -trichlorethane and its estimation in the tissues and body fluids. U.S. Public Health Rept. 59, 984 (1944).CrossRefGoogle Scholar
  161. Sazonova, N. A.: DDT toxic properties. Trans. XXth Session Plant Protection, Moscow, p. 37 (1952).Google Scholar
  162. Spassovsky, M. Kh.: Experimental data on DDT chronic toxicity. Trans. N.I.O.-T.R.Z. 165, 8 (1961).Google Scholar
  163. Spicer, S. S., T. R. von Sweeney, W. E. Octtinger, R. D. Lillie, and P. A. Neal: Toxicological observation on goats fed by large doses of DDT. Vet. Med. 42, 289 (1947).PubMedGoogle Scholar
  164. Stefansky, K. S.: Behaviour of DDT in soil. In: Hygiene and toxicology of pesticides and clinical aspects of poisoning 5, 73 (1967).Google Scholar
  165. Sternberg, J., S. W. Kearns, and W. N. Bruce: Absorption and DDT metabolism in organism of resistant and susceptible houseflies. J. Econ. Entomol. 43, 214 (1950).Google Scholar
  166. Sjöstrand, F. S.: Ultrastructure of cells as revealed by electron microscopy. Internat. Rev. Cytol. 5, 455 (1956).CrossRefGoogle Scholar
  167. Taryan, V. A., and G. Kemen: Storage of indecompensable pesticides in man’s tissue and hygienic significance of this phenomenon. Materials XVIth Sci. Sess. Nutrition Inst. Acad. Sci. U.S.S.R. 6, 2 and 84 (1966).Google Scholar
  168. Tobias, J. M., J. J. Kollrosa, and J. Sant: Acetylcholine and related substance in the cockroach, fly, and crayfish and the effect of DDT. J. Cell. Compar. Physiol. 28, 159 (1946).CrossRefGoogle Scholar
  169. Tostanokskaya, A. A., and S. G. Serebryanaya: Methodical letters on the work of the sanitary inspector concerning control of DDT and hexachlorine application in agriculture. Coll.: Official material concerning sanitation control of the application and examination of food products, p. 32, G.M.I. Ukr. S.S.R. (1960).Google Scholar
  170. Trotsenko-Klisenko, M. A.: On the question of mechanism of effect of chlororganic insecticides. Coll.: Hygiene and toxicology of new preparations and clinical aspects of poisoning, p. 272. Ed. “Mediz,” Moscow (1962).Google Scholar
  171. Tringer, K. S.: Structural bound water and biological mieromolecules. Progress Modern Biol. 61, 338 (1966).Google Scholar
  172. Tripod, J.: Le point d’attaque du DDT (4.4-dichlorphenyltrichloréthane) chez la grenouille. Arch. Internat. Pharmacol. 74, 343 (1947).Google Scholar
  173. Truhaut, E., and D. Vincent: Contribution à Fétude du mécanisme de Faction toxique de Finsecticide DDT et systemes cholinesterasiques chez les animaux supérieurs et les insectes. Bull. Soc. Chim. Biol. 30, 694 (1942).Google Scholar
  174. Vashkov, V. I., and N. A. Sazonova: Aerosol toxicity of DDT and hexachlorine for warm-blooded animals. Trans. U.N.I.D.I. 7, 186 (1951).Google Scholar
  175. Vashkov, V. I., L. I. Pogodina, and N. A. Sazonova: DDT and its use. Moscow “Medik” (1955).Google Scholar
  176. Vaskovskaya, M. F., and L. I. Komarova: Some data relating to DDT and DDE storage in human fatty tissues and their determination by means of thin-layer. In: Hygiene and toxicology Materials of the City Scient. Confer. of Young Scientists, Kiev (1965).Google Scholar
  177. Velbinger, H. H.: Beitrag zur Toxikologie des DDT (Wirkstoff Dichlordiphenyl-trichlormethylmethan). Die Pharmazie 6, 268 (1947).Google Scholar
  178. Wassermann, M., D. Wassermann, and L. Zellermayer: DDT and DDE in the body fat of people in Israel. Arch. Environ. Health 11, 375 (1965).PubMedGoogle Scholar
  179. Weiant, E. A.: Electrophysiological and behavioural studies on DDT-sensitive and DDT-resistant house flies. Ann. Entomol. Soc. Amer. 48, 489 (1955).Google Scholar
  180. Welsh, J., and P. Gordon: The mode of action of certain insecticides of the arthropod nerve axon. J. Cell. Comp. Physiol. 30, 147 (1947).CrossRefGoogle Scholar
  181. Welsh, R. M., W. Levin, and A. H. Conney: Insecticide inhibition and stimulation of steroid hydroxylases in rat liver. J. Pharm. Expt. Therap. 155, 167 (1967).Google Scholar
  182. White, W. C., and T. R. Sweeney: Review of the metabolism of chlorinated hydrocarbon insecticides especially in mammals. Public Health Rept. 60, 66 (1945).CrossRefGoogle Scholar
  183. Wigglesworth, V. B.: The mode of action of DDT. In: DDT, das Insektizid Dichlordiphenyltrichlorethan und seine Bedeutung. Basel-Stuttgart: P. Müller 1, 93 (1955).Google Scholar
  184. Williams, P. T.: Mechanism of detoxicity. Quoted from M. Maier-Bode: Pesticide residuals, Ed. “Mir,” Moscow (1966).Google Scholar
  185. Wilson, V. W.: Efficiency of WARF-antiresistant used as an addition to DDT preparation with a view to annihilating some species of houseflies resistant to DDT. J. Econ. Entomol. 55, 792 (1962).Google Scholar
  186. Winteringham, F. P., G. C. Hellyer, and M. A. McKay: Effect of the insecticides DDT and dieldrin on phosphorus metabolism of the adult house flies Musca domestica. L. Biochem. J. 76, 543 (1960).Google Scholar
  187. Winteringham, F. P., P. M. Lovedaga, and A. Harrison: Resistance of houseflies to DDT. Nature 167, 106 (1951).PubMedCrossRefGoogle Scholar
  188. Wong, D., and J. J. Tinsley: Preliminary observations of the effect of DDT ingestion on the soluble proteins of rat liver. Biochem. Pharmacol. 13, 534 (1964).PubMedCrossRefGoogle Scholar
  189. Woodard, G., V. Davidow, and A. J. Lehman: Metabolism of chlorhydrocarbon insecticides. Ind. Eng. Chem. 40, 711 (1948).CrossRefGoogle Scholar
  190. Woodward, J., A. Nelson, and H. Calvery: Acute and subacute toxicity of DDT to laboratory animals. J. Pharmacol. Expt. Therap. 82, 152 (1944).Google Scholar
  191. Yamasaki, T., and T. Narahashi: Effect of oxygen lack, metabolic inhibitors and DDT on the resting potential of insect nerve. Botyu-Kogaku 22, 259 (1957a).Google Scholar
  192. Woodward, J., A. Nelson: Increase in the negative afterpotential of insect nerve by DDT. Botyu-Kogaku 22, 296 (1957b).Google Scholar
  193. Woodward, J., A. Nelson: Intracellular microelectrode recordings of the resting and action potentials from the insect axon and the effects of DDT on the action potential. Botyu-Kogaku 22, 305 (1957c).Google Scholar
  194. Yakushko, V. E.: Glycolysis and its regulation by separate liver cell components at the influence of DDT and Sevin on warm-blooded animals. Coll.: Hygiene and toxicology materials of the City Scientific Conference of Young Scientific-Hygienists, Ed. “Zdorovye,” Kiev, p. 261 (1967).Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1969

Authors and Affiliations

  • Yu. S. Kagan
    • 1
  • S. I. Fudel-Ossipova
    • 1
  • B. J. Khaikina
    • 1
  • U. A. Kuzminskaya
    • 1
  • S. D. Kouton
    • 1
  1. 1.Union Scientific Research Institute Of Hygiene and Toxicology of Pesticides, Polymers and PlasticsKievU.S.S.R.

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