Abstract
The presence in the general food or water supply of any foreign chemical is a matter not to be dismissed lightly. The pesticides are poisons, of course, or they would not be useful in the control of insects, rodents, and other undesirable animals and plants. The ingestion by the population of small amounts of these pesticidal chemicals as residues on and in food has been viewed with alarm by a number of people. It is important, however, to consider the quantitative dose-response relationships involved.
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References
Alexander, N. M.: Iodide peroxidase in rat thyroid and salivary glands and its inhibition by antithyroid compounds. J. biol. Chem. 234, 1530 (1959 a).
Alexander, N. M.: Antithyroid action of 3-amino-l,2,4-triazole. J. biol. Chem. 234, 148 (1959 b).
A. M. A. Committee on Pesticides: Health problems of vaporizing and fumigating devices for insecticides. A supplementary report. J. Amer. med. Ass. 152, 1232 (1953).
A. M. A. Committee on Pesticides: Report to the Council. J. Amer. med. Ass. 162, 890 (1956).
A. M. A. Committee on Toxicology: Occupational dieldrin poisoning. J. Amer. med. Ass. 172, 2077 (1960).
Ammon, R.: Die fermentative Spaltung des Acetylcholins. Pflugers Arch. ges. Physiol. 233, 486 (1933).
Arterberry, J. D., W. F. Durham, J. W. Elliot, and H. R. Wolfe: Exposure to parathion. Measurement by blood cholinesterase level and urinary p-nitrophenol excretion. Arch, environm. Hlth 3, 476 (1961).
Astwood, E. B.: Cranberries, turnips, and goiter. J. Amer. med. Ass. 172, 1319 (1960).
Astwood, E. B., M. A. Greer, and M. G. Ettlinger: l-5-Vinyl-2-thiooxazolidone an antithyroid compound from yellow turnip and from brassica seeds. J. biol. Chem. 181, 121 (1949).
Axelrad, A., and C. P. Leblond: Thyroid tumor induction in rats by a low iodine diet with and without 2-acetylaminofluorene. Proc. Amer. Ass. Cancer Res. 1, 2 (1953).
Axelrad, A., and C. P. Leblond: Effect of iodide on the histological appearance of the thyroid tumors resulting from polonged exposure to a low iodine diet. Proc. Amer. Ass. Cancer Res. 1, 2 (1954).
Barnes, J. M., and F. A. Denz: Experimental demyelination with organo-phosphorus compounds. J. Path. Bact. 65, 597 (1953).
Barnes, J. M., and F. A. Denz: Experimental methods used in determining chronic toxicity. Pharmacol. Rev. 6, 191 (1954).
Bell, A.: Aldrin poisoning: A case report. Med. J. Aust. 47, 698 (1960).
Bennison, B. E., and F. K. Mostofi: Observations on inbred mice exposed to DDT. J. nat. Cancer Inst. 10, 989 (1950).
Bergenstal, D. M., M. B. Lipsett, R. H. Moy, and R. Hertz: Regression of adrenal cancer and supression of adrenal function in man by DDD. In biological activities of steroids in relation to cancer edited by G. Pincus and E. P. Vollmer. New York: Academic Press 1960, pp. 463.
Bidstrup, P. L., J. A. Bonnell, and A. G. Beckett: Paralysis following poisoning by a new organic phosphorus insecticide (Mipafox): Report on two cases. Brit. med. J. 1, 1068 (1953).
Bleiberg, M. J., M. Cefaratti, N. Klinman, and P. Kornblith: Studies of choline acetylase inhibition by DDA (dichlorodiphenylacetic acid) and its possible relationship to DDT toxicity. Toxicol, appl. Pharmacol. 4, 292 (1962).
Boggs, D. R., M. M. Wintrobe, and G. E. Cartwright: The acute leukemias. Medicine (Baltimore) 41, 163 (1962).
Braun, W.: Cancer of skin and internal organs caused by arsenic. Dtsch. med. Wschr. 83, 870 (1958).
Bronte-Stewart, B.: Lipids and atherosclerosis. Fed. Proc. 20, 127 (1961).
Brown, H. V., and A. F. BUSH: Parathion inhibition of cholinesterase. Arch. industr. Hyg. 1, 633 (1950).
Butlin, H. T.: Cancer of the scrotum in chimney sweeps and others. Lecture III. Tar and paraffin cancer. Brit. med. J. 2, 66 (1892).
Butlin, H. T.: California State Department of Argiculture, Bureau of Chemistry: Annual Report (1961)(Sacramento, California).
Cameron, G. R., and K. K. Cheng: Failure of oral DDT to induce toxic changes in rats. Brit. med. J. 2, 819 (1951).
Cavanagh, J. B., and P. Holland: Localization of cholinesterases in the chicken nervous system and the problem of the selective neurotoxicity of organo-phosphorus compounds. Brit. J. Pharmacol. 16, 218 (1961).
Cavanagh, J. B., R. Davies, P. Holland, and M. Lancaster: Comparison of the functional effects of dyflos, tri-o-cresyl phosphate, and tri-o-ethylphenyl phosphate in chickens. Brit. J. Pharmacol. 17, 21 (1961).
Claborn, H. V., H. F. Beckman, and R. W. Wells: Contamination of milk from DDT sprays applied to dairy barns. J. Econ. Entomol. 43, 723 (1950).
Clark, S. L., JR., C. L. Dodgen, and W. J. Darby: Further studies on renal toxicity of PGA. Proc. Soc. exp. Biol. (N. Y.) 84, 479 (1953).
Clifford, P. A.: Pesticide residues in fluid market milk. Publ. Hlth Rep. (Wash.) 72, 729 (1957).
Clifford, P. A., J. L. Bassen, and P. A. Mills: Chlorinated organic pesticide residues in fluid milk. Publ. Hlth Rep. (Wsh.) 74, 1109 (1959).
Cook, J. W., J. R. Blake, G. Yip, and M. Williams: Malathionase. 1. Activity and inhibition. J. Assoc. Offic. Agr. Chemists 41, 399 (1958).
Cottam, C.: Pesticides and water pollution. Proc. of National Conference on Water Pollution, Washington D. C., Dec. 12–14 (I960), p. 222.
Cronkite, E. P.: Evidence for radiation and chemicals as leukemogenic agents. Arch, environm. Hlth 3, 297 (1961).
Cueto, C., JR., and W. J. Hayes, JR.: Detection of a dieldrin metabolite in human urine. Presented Amer. Chem. Soc. National Meeting, Chicago, 111., Sept. 3–8 (1961).
Cueto, C., A. G. Barnes, and A. M. Mattson: DDT in humans and animals. Determination of DDA in urine using an ion exchange resin. J. Agr. Food Chem. 4, 943 (1956).
Darby, W. J.: Food: additives and natural components. Fed. Proc. 19, 10 (Suppl. 4) (1960).
Davies, D. R., P. Holland, and M. J. Rumens: The relationship between the chemical structure and neurotoxicity of alkyl organophosphorus compounds. Brit. J. Pharmacol. 15, 271 (1960).
Davies, G. M., and I. Lewis: Outbreak of food poisoning from bread made of chemically contaminated flour. Brit. med. J. 2, 393 (1956).
Davis, K. J., and O. G. Fitzhugh: Tumorigenic potential of aldrin and dieldrin for mice. Toxicol, appl. Pharmacol. 4, 187 (1962).
Dean, L. A.: Discussion on pesticides and water pollution. Proc. of National Conference on Water Pollution, Wash. D. C, Dec. 12–14 (1960), p. 236.
Decker, G. C.: Significance of pesticide residues in milk and meat. J. Agr. Food Chem. 7, 681 (1959).
Deichmann, W. B., S. Witherup, and K. V. Kitzmiller: The toxicity of DDT. Experimental observations. Kettering Laboratory, University of Cincinnati (1950).
Doll, R.: Etiology of lung cancer. Adv. Cancer Res. 3, 1 (1955).
Du Bois, K. P., J. Doull, P. R. Salerno, and J. M. Coon: Studies on the toxicity and mechanism of action of nitrophenyl diethyl thionophosphate (parathion). J. Pharmacol, exp. Ther. 95, 79 (1949).
Durham, W. F.: Analytic methods for pesticides and antibiotics in food. Publ. Hlth Lab. 19, 47 (1961)
Durham, W. F., and f. J. Hayes, JR.: Toxicology of dieldrin III. The effect of dermal application on liver biochemistry in the rat. (Manuscript in preparation.)
Durham, W. F., and H. R. Wolfe: Studies on some potential health hazards associated with insecticide residues on pome fruits. Proc. Wash. St. Hort. Ass. 55, 127 (1959).
Durham, W. F.Measurement of the exposure of workers to pesticides. Bull. Wld Hlth Org. 26, 75 (1962).
Durham, W. F., J. F. Armstrong, W. M. Upholt, and C. Heller: Insecticide content of diet and body fat of Alaskan natives. Science 134, 1880 (1961).
Durham, W. F., C. Cueto, JR., and W. J. Hayes, JR.: Hormonal influences on DDT metabolism in the white rat. Amer. J. Physiol. 187, 373 (1956 a).
Durham, W. F.,T. B. Gaines, and W. J. Hayes, JR.: Paralytic and related effects of certain organic phosphorus compounds. Arch environm. Hlth 13, 326 (1956 b).
Durham, W. F., P. Ortega, and W. J. Hayes, JR.: The effect of various dietary levels of DDT on liver function, cell morphology, and DDT storage in the Rhesus monkey. Arch. int. Pharmacodyn. 141, 111 (1963).
Du Shane, G.: Cranberry smash. Science 130, 1447 (1959).
Edson, E. F.: The effect of prolonged ingestion of low dosages of schradan in humans. Fisons Pest Control, Ltd., Med. Dept., mimeographed release (1955).
Edson, E. F.: The effects of prolonged administration of small daily doses of Dimefox in the rat, pig, and man. Fisons Pest Control, Ltd., Med. Dept., mimeographed release (1956).
Edson, E. F.: The effects of prolonged administration of small daily doses of parathion in the rat, pig, and man. Fisons Pest Control, Ltd., Med Dept., mimeographed release (1957).
Eggert, R. G.: Unpublished observation. Cited in Jukes, T. H., and C. B. Shaffer: Antithyroid effects of aminotriazole. Science 132, 296 (1960).
Elliott, J. W., K. C. Walker, A. E. Penick, and W. F. Durham: Insecticide exposure. A sensitive procedure for urinary nitrophenol determination as a measure of exposure to parathion. J. Agr. Food Chem. 8, 111 (1960).
Engelhorn, R.: Über den Einfluß des Äthyl-urethans und des Phenylcarbamin- säure-isopropylesters auf das Lungengewebe der Ratte. Arch. exp. Path. Parmakol. 223, 117 (1954).
Erslev, A. J., and M. M. Wintrobe: Detection and prevention of drug-induced blood dyscrasias. J. Amer. med. Ass. 181, 114 (1962).
Esch, G. J., H. Van Genderen, and H. H. Vink: The production of skin tumors in mice by oral treatment with urethane, isopropyl-N-phenyl carbamate or isopropyl-N-chlorophenyl carbamate in combination with skin painting with croton oil. Brit. J. Cancer 12, 355 (1958).
Fitzhugh, O. G., and A. A. Nelson: Chronic oral toxicity of DDT (2,2-bis(p- chloropheny 1)-1,1,1 -trichloroethane). J. Pharmacol, exp. TTier. 89, 18 (1947).
Fowler, R. E. L.: Insecticide toxicology — Manifestations of cottonfield insecticides in the Mississippi Delta. J. Agr. Food chem. 1, 469 (1953).
Frawley, J. P., R. E. Zwickey, and H. N. Fuyat: Myelin degeneration in chickens with subacute administration of organic phosphorus insecticides. Fed. Proc. 15, 424 (1956).
Frawley, J. P., R. E. Zwickey, and H. N. Fuyat, H. N. Fuyat, E. C. H. Gan, J. R. Blake, and O. G. Fitzhugh: Marked potentiation in mammalian toxicity from simultaneous administration of two anticholinesterase compounds. J. Pharmacol, exp. Ther. 121, 96 (1957).
Friberg, L., and J. Martensson: Case of panmyelophthisis after exposure to chlorophenothane and benzene hexachloride. Arch, industr. Hyg. 8, 166 (1953).
Frost, D. V.: Considerations on the reality of cancer due to arsenic; organic arsenicals in medicated feeds. Abbot Laboratories, North Chicago, 111., mimeographed release (1961).
Gaines, T. B.: The acute toxicity of pesticides to rats. Toxicol, appl. Pharmacol. 2, 88 (1960).
Ganelin, R. S., C. Cueto, and G. A. Mail: Use of insecticides in agriculture. Measurement of exposure and effect on the general population. Manuscript in preparation.
Goldblatt, M. W.: Organic phosphorus insecticides and the antidotal action of atropine. Pharm. J. 164, 229 (1950).
Golz, H. H.: Controlled human exposures to malathion aerosols. Arch, environm. Hlth 19, 516 (1959).
Greenwood, D. A., L. E. Harris, C. Biddulph, G. Q. Bateman, W. Binns, M. L. Miner, J. R. Harris, F. Mangelson, and L. L. Madsen: Feeding rats tissues from lambs and butterfat from cows that consumed DDT-dusted alfalfa hay. Proc. Soc. exp. Biol. (N.Y.) 83, 458 (1953).
Greer, M. A., and E. B. Astwood: Antithyroid effect of certain foods in man as determined with radioactive iodine. Endocrinology 43, 105 (1948).
Griesbach, W. E.: Studies on experimental goitre; changes in anterior pituitary of rat, produced by brassica seed diet. Brit. J. exp. Path. 22, 245 (1941).
Griesbach, W. E.:, T. H. Kennedy, and H. D. Purves: Studies on experimental goitre. VI. Thyroid adenomata in rats on brassica seed diet. Brit J. exp. Path. 26, 18 (1945).
Grob, D., and A. M. Harvey: Observations on the effects of tetraethyl pyrophosphate in man and on its use in the treatment of myasthenia gravis. Bull. Johns Hopk. Hosp. 84, 543 (1949).
Gunther, F., and R. C. Blinn: Analysis of insecticides and acaricides. New York: Inter science 1955.
Haag, H. B., J. K. Finnegan, P. S. Larson, M. L. Dreyafuss, R. J. Main, and W. Riese: Comparative chronic toxicity for warm-blooded animals of 2,2- bis (p-chloropheny 1) 1,1,1-trichloroethane (DDT) and 2,2-bis(p-chlorophenyl)- 1,1-dichloroethane (DDD). Ind. Med. 17, 477 (1948).
Harris, R. S.: Influences of culture on man’s diet. Arch, environm. Hlth 5, 144 (1962).
Harwell, J. L., M. J. Shear, J. M. Johnson, and S. R. L. Kornberg: Present status of a joint institutional research program on chemotherapy of cancer. VI. Selection and synthesis of organic compounds. Cancer Res. 6, 489 (1946).
Harvey, D. G., P. L. Bidstrup, and J. A. L. Bonnell: Poisoning by dinitro-ortho-cresol. Some observations on the effects of dinitro-ortho-cresol administered by mouth to human volunteers. Brit. med. J. 2, 13 (1951).
Hayes, W. J., JR.: Present status of our knowledge of DDT intoxication. Amer. J. Publ. Hlth 45, 478 (1955).
Hayes, W. J., JR.: Dieldrin poisoning in man. U.S. Publ. Hlth Rep. 72, 1087 (1957).
Hayes, W. J., JR.: The toxicity of dieldrin to man; report on a survey. Bull. Wld Hlth Org. 20, 891 (1959 a).
Hayes, W. J., JR.: Pharmacology and toxicology of DDT. Chapter VI in “DDT, the insecticide dichlorodiphenyltrichloroethane and its significance”. Paul Muller, Vol. II, Basel: Birkhauser Verlag (1959 b).
Hayes, W. J., JR.: Pesticides in relation to public health. Ann. Rev. Entomol. 5, 379 (1960).
Hayes, W. J., JR.: Diagnostic problems in toxicology (agriculture). Arch, environ. Hlth 3, 49 (1961).
Hayes, W. J., JR., W. E. Dale, and C. I. Pirkle: Manuscript in preparation (1963).
Hayes, W. J., JR., E. M. Dixon, G. S. Batchelor, and W. M. Upholt: Exposure to organic phosphorus sprays and occurrence of selected symptoms. Publ. Hlth Rep. (U.S.) 72, 787 (1957).
Hayes, W. J., JR., W. F. Durham, and C. Cueto, JR.: The effect of known repeated oral doses of chlorophenothane (DDT) in man. J. Amer. med. Ass. 162, 890 (1956).
Hayes, W. J., JR., and R. E. Serfling: The rate of storage and excretion of DDT in the rat.(Manuscript in preparation.)
Hayes, W. J., JR., A. M. Mattson, J. G. Short, and R. F. Witter: Safety of malathion dusting powder for louse control. Bull. Wld Hlth Org. 22, 503 (I960).
Hayes, W. J., JR., G. E. Quinby, K. C. Walker, J. W. Elliott, and W. M. Upholt: Storage of DDT and DDE in people with different degrees of exposure to DDT. Arch, environm. Hlth 18, 398 (1958).
Hess, H.: Arseninhalation und Bronchialcarcinom bei Winzern. Arch. klin. Chir. 283, 274 (1956).
Holland, R. H., R. H. Wilson, A. R. Acevedo, M. S. McCall, D. A. Clark, and H. C. Lang: A study of arsenic in regular sized unfiltered and filtered cigarettes. Cancer 11, 1115 (1958).
Hoshino, M.: Effect of 3-amino-l,2,4-triazole on the experimental production of liver cancer. Nature 186, 174 (1960).
Howell, D. E.: A case of DDT storage in human fat. Proc. Oklahoma Acad. Sci. 29, 31 (1948).
Hsieh, H. C.: D.D.T. Intoxication in a family of Southern Taiwan. Arch, industr. Hyg. 10, 344 (1954).
Hueper, W. C., and W. W. Payne: Experimental studies in metal carcinogensis: chromium, nickel, iron, arsenic. Arch, environ. Hlth 5, 445 (1962).
Hunter, D., K. M. A. Perry, and R. B. Evans: Toxic polyneuritis arising during manufacture of tricresyl phosphate. Brit. J. industr. Med. 1, 227 (1944).
Jedlicka, V. L., 2. Hermanska, I. Smida, and A. Kouba: Paramyeloblast leukemia appearing simultaneously in two blood cousins after simultaneous contact with gammexane (hexachlorocyclohexane). Acta med. scand. 161, 447 (1958).
Joslin, E. F., R. L. Forney, R. W. Huntington, JR., and W. J. Hayes, JR.: A fatal case of lindane poisoning. Proc. National Assoc. of Coroners. Seminars: 1958 and 1959, p. 53 (I960).
Jukes, T. H., and C. B. Shaffer: Antithyroid effects of aminotriazole. Science 132, 296 (1960).
Kanagaratnam, K., W. H. Boon, and T. K. Höh: Parathion poisoning from contaminated barley. Lancet 1, 538 (1960).
Karunakaran, C. O.: The Kerala food poisoning. J. Indian med. Ass. 31, 204 (1958).
Kennaway, E. L.: Anatomic distribution of occupational cancers. II. A comparison of the anatomic distribution of cancers due to arsenic, pitch and tar, and shale oil. J. industr. Hyg. 7, 80 (1925).
Kennaway, E. L.: A contribution to the mythology of cancer research. Lancet 2, 769 (1942).
Kleinman, G. D., I. West, and M. S. Augustine: Occupational disease in California attributed to pesticides and agricultural chemicals. Arch, environ. Hlth 1, 118 (1960).
Koelle, G. B., and A. Gilman: Chronic toxicity of di-isopropyl fluorophosphate (DFP) in dogs, monkeys and rats. J. Pharmacol, exp. Ther. 87, 435 (1946).
Koelle, G. B., and A. Gilman: Anticholinesterase drugs. Pharmacol. Rev. 1, 166 (1949).
Koelsch, F.: Die beruflichen Arsenschäden im Weinbau und in den gewerblichen Betrieben. Arch. Gewerbepath. Gewerbehyg. 16, 405 (1958).
Kunze, F., A. A. Nelson, O. G. Fitzhugh, and E. P. Laug: Storage of DDT in the fat of the rat. Fed. Proc. 8, 311 (1949).
Kwoczek, J.: Uber die Toxizität der DDT und Hexachlorzyklohexanpräparate. Med. Msdir. 4, 25 (1950).
Larsen, C. D.: Evaluation of carcinogenicity of series of esters of carbamic acid. J. nat. Cancer Inst. 8, 99 (1947).
Larson, P. S., E. M. Crawford, R. B. Smith, JR., G. R. Hennigar, H. B. Haag, and J. K. Finnegan: Chronic toxicologic studies on isopropyl N-(3-chloro- phenyl) carbamate (CIPC). Toxicol, appl. Pharmacol. 2, 659 (1960).
Laug, E. P., F. M. Kunze, and C. S. Prickett: Occurrence of DDT in human fat and milk. Arch, industr. Hyg. 3, 245 (1951).
Lehman, A. J.: Chemicals in foods: A report to the association of food and drug officials on current developments. Part II. Pesticides. Assoc. Food salvoro: Drug Officials U.S. Quart. Bull. 15, 122 (1951).
Lehman, A. J., F. A. Vorhes, L. L. Ramsey, E. C. Hagan, O. G. Fitzhugh, P. J. Schouboe, J. H. Draize, E. I. Goldenthal, W. D’Aguanno, E. P. Laug, E. J. Umberger, G. H. Gass, R. E. Zwickey, K. J. Davis, H. A. Braun, A. A. Nelson, and B. J. Vos: Appraisal of the safety of chemicals in foods, drugs, and cosmetics. Hie Editorial Committee, Association of Food and Drug Officials of the United States, Austin, Tex., 107 pp. (1959).
Lemmon, A. B.: Bureau of Chemistry. Annual report for ttie calendar year 1955. Calif. Dept. Agr. Bull. 45, 128 (1956).
Maier-Bode, H.: DDT im Körperfett des Menschen. Med. exp. (Basel) 1, 146 (1960).
Mann, H. D., R. H. Carter, and R. E. Ely: The DDT content of milk products. J. Milk and Food Technol. 13, 340 (1950).
Marchand, J. F.: Microtests for Cholinesterase: Interpretation after nerve gas or agricultural insecticide exposures. J. Amer. med. Ass. 149, 738 (1952).
Marchand, M., P. Dubrulle, and M. Goudenard: A granulocytosis in a patient exposed to hexachlorocyclohexane vapors. Arch. Mai. prof. 17, 256 (1956).
Marth, E. H.: Chlorinated hydrocarbons deposited in biological material. I. Plant and plant products. J. Milk and Food Technol. 25, 36 (1962).
Mattson, A. M., and V. A. Sedlak: Measurement of insecticide exposure — Ether- extractable urinary phosphates in man and rats derived from malathion and similar compounds. J. Agr. Food Chem. 8, 107 (1960).
Mattson, A. M., J. T. Spillane, C. Baker, and G. W. Pearce: Determination of DDT and related substances in human fat. Anal. Chem. 25, 1065 (1953).
Mcgee, L. C.: The toxicology of some agricultural chemicals: A review of accidental poisoning of human beings by chlorinated insecticides. Trans. Amer. clin. climat. Ass. 68, 69 (1956).
Mattson, A. M., H. L. Reed, and J. P. Fleming: Accidental poisoning by toxaphene: Review of toxicology and case reports. J. Amer. med. Ass. 149, 1124 (1952).
Meneely, G. R., C. O. T. Ball, and J. B. Youmans: Chronic toxicity: The protective effect of added potassium chloride. Ann. intern. Med. 47, 263 (1957).
Metcalf, R. L.: The colorimetric micro-estimation of human blood cholinesterases and its application to poisoning by organic phosphate insecticides. J. Econ. Entomol. 44, 883 (1951).
Michel, H. O.: An electrometric method for the determination of red blood cell and plasma cholinesterase activity. J. Lab. clin. Med. 34, 1564 (1949).
Mitchell, H. S., and W. M. Dodge: Cataract in rats fed on high lactose rations. J. Nutr. 9, 37 (1935).
Moeller, H. C., and J. A. Rider: Plasma and red blood cell cholinesterase activity as indications of the threshold of incipient toxicity of ethyl-p-nitro-phenyl thionobenzenephosphonate (EPN) and malathion in human beings. Toxicol, appl. Pharmacol. 4, 123 (1962).
Morris, H. P., and C. D. Green: The role of thiouracil in the induction, growth, and transplantability of mouse thyroid tumors. Science 114, 44 (1951).
Mulford, K. E.: Food additives legislation and food technology. Industry’s viewpoint on the effcts of the legislation. Arch, environ. Hlth 2, 212 (1961).
Murphy, S. D., and K. P. Du Bois: Quantitative measurement of inhibition of the enzymatic detoxification of malathion by EPN (ethyl p-nitrophenyl thionobenzenephosphonate). Proc. Soc. exp. Biol. (N.Y.) 96, 813 (1957).
Murphy, S. D., R. L. Anderson, and K. P. Du Bois: Potentiation of toxicity of malathion by triorthotolylphosphate. Proc. Soc. exp. Biol. (N.Y.) 100, 483 (1959).
National Research Council, Food Protection Committee, Food and Nutrition Board: Problems in the evaluation of carcinogenic hazard from use of food additives. NAS-NRC Publ. 749 (1960).
Neal, P. A., W. C. Dreessen, T. I. Edwards, W. H. Reinhart, S. H. Webster, H. T. Castberg, and L. T. Fairhall: A study of the effect of lead arsenate exposure on orchardists and consumers of sprayed fruit. Publ. Hlth Bull. No. 267 (1941).
Nelson, A. A., and G. Woodard: Adrenal cortical atrophy (cytotoxic) and hepatic damage produced in dogs by feeding 2,2-bis-(parachlorophenyl)-l,l- dichloroethane (DDD or TDE). Arch. Path. 48, 387 (1949).
Neubauer, O.: Arsenical cancer. A review. Brit. J. Cancer 1, 192 (1947.)
Nicholson, H. P.: Pesticide pollution studies in the Southeastern United States. Proceedings Third Seminar on Biological Problems in Water Pollution, Cincinnati, Ohio, Aug. 13–16 (1962).
O’Brien, R. D.: Toxic phosphorus esters. Chemistry, metabolism, and biological effects. New York-London: Academic Press 1960.
Ortega, P.: Light and electron microscopy of rat liver after feeding with DDT. Fed. Proc. 21 (2), 306 (1962).
Ortega, P., W. J. Hayes, JR., W. F. Durham, and A. M. Mattson: DDT in the diet of the rat — its effect on DDT storage, liver function and cell morphology. Publ. Hlth Monograph (U.S.) No. 43 (1956).
Ortega, P. Pathologic changes in the liver of rats after feeding low levels of various insecticides. Arch. Path. 64, 614 (1957).
Ortelee, M. F.: Study of men with prolonged intensive occupational exposure to DDT. Arch, industr. Hlth 18, 433 (1958).
Oser, B. L.: The experimental induction of cancer by pesticide residues and food additives: Its rationale and interpretation. Residue Reviews 1, 1 (1962).
Oser, B. L., and M. Oser: 2-(p-tert-butylphenoxy)isopropyl 2-chloroethyl sulfite (aramite). I. Acute, subacute, and chronic oral toxicity. Toxicol, appl. Pharmacol. 2, 441 (1960).
Paris, J. A.: Pharmacologia; comprehending the art of prescribing upon fixed and scientific principles together with the history of medicinal substances. London: W. Phillips, 5th Ed. (1822).
Paschkis, K. E., A. Cantarow, and J. Stasney: Influence of thiouracil on carcinoma induced by 2-acetaminofluorene. Cancer Res. 8, 257 (1948).
Pearce, G. W., A. M. Mattson, and W. J. Hayes, JR.: Examination of human fat for the presence of DDT. Science 116, 254 (1952).
Perry, W. J., and L. J. Bodenlos: 2,2-bis(p-chlorophenyl-l,l,l-trichloroethane (DDT) determinations in tissues, body fluids and excreta of human subjects. Mosquito News 10, 1 (1950).
Priode, B. M., and M. J. Burris: Quoted in Anonymous: Apple pomace. Agr. Res. 7, 3 (1958).
Popper, H., S. S. Sternberg, B. L. Oser, and M. Oser: The carcinogenic effect of aramite in rats. A study of hepatic nodules. Cancer 13, 1035 (1960).
Purves, H. D., and W. E. Griesbach: Studies on experimental goitre. VIII. Thyroid tumors in rats treated with thiourea. Brit. J. exp. Path. 28, 46 (1947).
Quinby, G. E., and A. B. Lemmon: Parathion residues as a cause of poisoning in crop workers. J. Amer. med. Ass. 166, 740 (1958).
Quinby, G. E., T. A. Loomis, and H. W. Brown: Oral occupational parathion poisoning treated with 2-PAM iodide (2-pyridine aldoxime methiodide). New Engl. J. Med. 268, 639 (1963).
Quinby, G. E., K. C. Walker, and W. F. Durham: Public health hazards involved in the use of organic phosphorus insecticides in cotton culture in the Delta area of Mississippi. J. Econ. Entomol. 51, 831 (1958).
Quinby, G. E., W. J. Hayes, JR., and W. F. Durham: Manuscript in preparation (1963).
Read, S. T., and W. P. McKinley: DDT and DDE content of human fat: Survey. Arch, environ. Hlth 3, 209 (1961).
Rider, J. A., H. C. Moeller, J. S Wader, and R. W. Weilerstein: The effect of parathion on human red blood cell and plasma Cholinesterase. Section II. Arch, industr. Hlth 18, 442 (1958).
Riker, W. F., JR.: Contributions to medicine by research in pharmacology. Some aspects of dosage. J. Amer. med. Ass. 179, 355 (1962).
Roe, R. S.: Pesticide residues in relation to the food, drug and cosmetic act. The nature and fate of chemicals applied to soils, plants, and animals. Symposium sponsored by the Agricultural Research Service, USD A, Beltsville, Md., ARS 20–9 (I960).
Rollins, R. Z.: Laws and regulations pertaining to use of pesticides by mosquito abatement districts. Calif. Vector Views 8, 1 (1961).
Roth, F.: Arsen, Leber, Tumoren; Hämangioendotheliom. Z. Krebsforsch. 61, 468 (1957 a).
Roth, F.: Über die Spätfolgen des chronischen Arsenismus der Moselwinzer. Dtsch. med. Wschr. 82, 211 (1957 b).
Roth, F.: Über den Bronchialkrebs arsengeschädigter Winzer. Arch. Pathol. Anat. Physiol. 331, 119 (1958).
Salter, W. T.: Chemistry of carcinogens. Occupat. Med. 5, 441 (1948).
Sarett, H. P., and B. J. Jandorg: Effects of chronic DDT intoxication in rats on lipids and other constituents of liver. J. Pharmacol, exp. Ther. 91, 340 (1947).
Schechter, M. S., and I. Hornstein: Chemical analysis of pesticide residues. Adv. Pest Control Res. 1, 353 (1957).
Schechter, M. S., and W. E. Westlake: Chemical residues and the analytical chemist. Anal. Chem. 34, 25 A (1962).
Seifert, P.: Giftmord mit E-605 an einem Säugling. Arch. Toxikol. 15, 80 (1954).
Seume, F. W., and R. D. O’Brien: Metabolism of malathion by rat tissue preparations and its modification by EPN. J. Agr. Food. Chem. 8, 36 (1960 a).
Seume, F. W., and R. D. O’Brien: Potentiation of the toxicity to insects and mice of phosphorothionates containing carboxyester and carboxyamide groups. Toxicol, appl. Pharmacol. 2, 495 (1960 b).
Smith, H. V., and J. M. K. Spalding: Outbreak of paralysis in Morocco due to ortho-cresyl phosphate poisoning. Lancet 2, 1019 (1959).
Smith, M. I., and R. D. Lillie: Histopathology of triorthocresyl phosphate poisoning: Etiology of so-called ginger paralysis. Arch. Neurol. Psychiat. (Chic.) 26, 976 (1931).
Smith, M. I., E. Elvove, and W. H. Frazier: The pharmacological action of certain phenol esters, with special reference to the etiology of so-called ginger paralysis. Second rep. Publ. Hlth Rep. (U.S.) 45, 2509 (1930).
Sternberg, S. S., H. Popper, B. L. Oser, and M. Oser: Gall bladder and bile duct adenocarcinomas in dogs following chronic feeding of aramite. Amer. J. Pathol. 35, 691 (1959).
Sternberg, S. S., H. Popper, B. L. Oser, and M. Oser: Gall bladder and bile duct adenocarcinomas in dogs after long term feeding of aramite. Cancer 13, 780 (1960).
Storen, G.: A case of fatal poisoning by Jacutin (Lindane) insecticide and moth protective agent. Nord. hyg. T. 36, 77 (1955).
Sumerford, W. R., W. J. Hayes, JR., J. M. Johnston, K. Walker, and J. Spillane: Cholinesterase response and symptomatology from exposure to organic phosphorus insecticides. Arch, industr. Hyg. 7, 383 (1953).
Szepsenwol, J.: Carcinogenic effect of hens eggs as part of the diet in mice. Proc. Soc. exp. Biol. Med. 102, 748 (1959).
Terriere, L. C., G. H. Arscott, and U. Kiigemagi: The endrin content of eggs and body tissue of poultry receiving endrin in their daily diet. J. Agr. Food Chem. 7, 502 (1959).
Treon, J. F., and F. P. Cleveland: Toxicity of certain chlorinated hydrocarbon insecticides for laboratory animals, with special reference to aldrin and dieldrin. J. Agr. Food Chem. 3, 402 (1955).
Underwood, E. J.: Trace elements in human and animal nutrition. New York: Academic Press 1956.
Unna, K., and J. G. Greslin: Studies on toxicity and pharmacology of riboflavin. J. Pharmacol, exp. Ther. 76, 75 (1942).
Upholt, W. M.: Personal communication.
Upholt, W. M., G. E. Quinby, and G. S. Batchelor: Eating systox-treated fruit under controlled conditions. Proc. Wash. St. Hort. Ass. 50, 217 (1954).
U. S. Department of Health, Education, and Welfare: Annual Report (1962).
U. S. Food and Drug Administration: Statements of general policy on interpretation: Apple pomace containing DDT. Federal Register 23, 7815 (1958).
U.S. Food and Drug Administration: Statements of general policy on interpretation. Federal Register 27, 12 091 (1962).
Vallee, B. L., D. D. Ulmer, and W. E. C. Wacker: Arsenic toxicology and biochemistry. Arch, industr. Hlth 21, 132 (1960).
Walker, K. C., M. B. Goette, and G. S. Batchelor: Dichlorodiphenyltrichloro-ethane and dichlorodiphenyldichloroethylene content of prepared meals. J. Agr. Food Chem. 2, 1034 (1954).
Weir, R. J., and J. G. Keller: Toxicology of delnav. Am. Chem. Soc. National Meeting, Atlantic City, N. J. (1962).
Westlake, W. E.: Pesticides. Anal. Chem. 31, 724 (1959).
Wile, U. J.: Arsenical cancer with report of a case. J. cutan. Dis. 30, 192 (1912).
Witter, R. F.: Measurement of blood cholinesterase. Arch, environ. Hlth 6, 537 (1963).
Wolfe, H. R., W. F. Durham, and J. F. Armstrong: Health hazards of the pesticides endrin and dieldrin: Hazards in some agricultural uses in the Pacific Northwest. Arch, environ. Hlth 6, 458 (1963).
Wolfe, H. R., J. W. Elliott, and W. F. Durham: The trend of DDT and parathion residues on apples grown in Central Washington. J. Econ. Entomol. 52, 1053 (1959).
World Health Organization: Evalution of the carcinogenic hazards of food additives. Fifth report of the joint FAO/WHO Expert Committee on Food Additives. Wld Hlth Org. Tech. Rep. Ser. 220 (1961).
Zweig, G., L. M. Smith, S. A. Peoples, and R. Cox: Insecticide residues in milk — DDT residues in milk from dairy cows fed low levels of DDT in their daily rations. J. Agr. Food Chem. 9, 481 (1961).
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Durham, W.F. (1963). Pesticide residues in foods in relation to human health. In: Gunther, F.A. (eds) Residue Reviews / Rückstands-Berichte. Residue Reviews / Ruckstands-Berichte, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-8380-6_4
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