Abstract
The Abruptex (Ax, 1–3.0) alleles of the Notch locus of Drosophila melanogaster exhibit an interesting type of allelic interaction, namely negative complementation. Heterozygous combinations of certain viable alleles are lethal or semilethal. In such allele pairs, one is always a suppressor of the expression of Notch mutants, while the other is either an enchancer of Notch or has a neutral effect on Notch (Foster, 1975; Portin, 1975).
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References
Demerec, M., 1941, The nature of changes in the white-Notch region of the X-chromosome of Drosophila melanogaster, in: “Proc. 7th Int. Genet. Congr. Edinburgh 1939,” J. Genet. Suppl., 1:99.
Foster, G.G., 1975, Negative complementation at the Notch locus of Drosophila melanogaster, Genetics, 81:99.
Portin, P., 1975, Allelic negative complementation at the Abruptex locus in Drosophila melanogaster, Genetics, 81:121.
Portin, P., 1977, Analysis of the negative complementation of Abruptex alleles in gynandromorphs of Drosophila melanogaster, Genetics, 86:309.
Portin, P., 1980, On the cell lethality of Notch and Abruptex mutations of Drosphila melanogaster, Hereditas, 92:303.
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© 1982 Plenum Press, New York
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Portin, P. (1982). Allelic Negative Complementation in the Notch Locus of Drosophila Melanogaster at the Morphological Level. In: Lakovaara, S. (eds) Advances in Genetics, Development, and Evolution of Drosophila. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8321-9_7
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DOI: https://doi.org/10.1007/978-1-4615-8321-9_7
Publisher Name: Springer, Boston, MA
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