Abstract
The interaction of literally hundreds—perhaps thousands—of genes is required for the development of a normal human ear. Consequently, defects in any one of a great many genes can lead to hearing loss. The recognition that hereditary deafness is not a single disease but a collection of distinct genetic disorders which have one symptom in common is one of the most important insights that have been gained from contemporary genetic research. Mutant genes have always been an important cause of hearing impairment, but with the progressive identification and control of environmental causes of hearing loss, hereditary factors will doubtless account for an even greater proportion of the deaf population in the future. Our intent here is to provide a common body of genetic knowledge for the array of professional groups—including geneticists, audiologists, otolaryngologists, pediatricians, social workers, and educators—who provide services for the hearing-impaired. We believe that, if further progress is to be made in the prevention, treatment, and education of the deaf, it will have to come about through a more widespread recognition of hereditary deafness syndromes and the special problems each presents.
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Nance, W.E., McConnell, F.E. (1973). Status and Prospects of Research in Hereditary Deafness. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics. Advances in Human Genetics, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8261-8_3
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