Abstract
In recent years, immunohistochemical detection and localization of specific antigens in tissue sections have had important clinical and experimental applications. Morphological information derived from these studies combined with biochemical data is proving to be an extremely valuable means for studying structural and functional components of tissue. Biochemical data describing brain antigens have prompted many immunohistochemical studies attempting to localize these factors. Whereas most studies have employed the immunofluorescence technique, the increasing requirement for high-resolution localization offered by electron microscopy (EM) necessitates the use of immunoperoxidase methods Immunocytochemical localization of brain antigens is lending a great deal to our understanding of brain morphology, organization, and function. Many but not all of the nervous system antigens being studied by immunohistochemical techniques have been cited in this chapter. The authors have attempted to concentrate on areas of most recent advances and of broad general interest.
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References
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Eng, L.F., Bigbee, J.W. (1978). Immunohistochemistry of Nervous System-Specific Antigens. In: Agranoff, B.W., Aprison, M.H. (eds) Advances in Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8240-3_2
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