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2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase

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Advances in Neurochemistry

Abstract

2′,3′-Cyclic nucleotide 3′-phosphodiesterase (CNPase, EC 3.1.4.37*) has been widely used for several years as a marker for the presence of myelin in the central nervous system, but no review is available on its application and limitation as a marker enzyme and there is no information on its role in myelin. This was the first enzyme to be unequivocally characterized as a myelin component; previously it had been thought that myelin was enzymatically inert (Adams et al., 1963). Several other enzymes have now been proposed as being myelin-associated (for references see Carnegie and Sims, 1977; Norton, 1977), but evidence of myelin association is incomplete for some of these, such as protein kinase (Carnegie et al., 1974; Miyamoto and Kakiuchi, 1974; Steck and Appel, 1974; Miyamoto, 1976) and phosphoprotein phosphatase (Miyamoto and Kakiuchi, 1975). In the case of nonspecific esterase (Keoppen et al., 1969; Frey et al., 1971; Rumsby et al., 1973; Mitzen et al., 1974) and arylamidase (Banik and Davison, 1969; Riekkinen and Clausen, 1970; Riekkinen and Rumsby, 1972; Mezei and Palmer, 1974) there is some controversy as to whether the enzymes are truly myelin-associated or are bound as an artifact of the preparation of myelin. There is strong evidence that cholesterol ester hydrolase is a myelin enzyme (Eto and Suzuki, 1973). The evidence that CNPase is a true myelin component is presented herein.

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Authors and Affiliations

  1. The Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, Australia

    Neil Raymond Sims & Patrick Robert Carnegie

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  1. Neil Raymond Sims
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  1. Mental Health Research Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA

    B. W. Agranoff

  2. Institute of Psychiatric Research and Department of Psychiatry and Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana, USA

    M. H. Aprison

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© 1978 Plenum Press, New York

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Sims, N.R., Carnegie, P.R. (1978). 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase. In: Agranoff, B.W., Aprison, M.H. (eds) Advances in Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8240-3_1

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  • DOI: https://doi.org/10.1007/978-1-4615-8240-3_1

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