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Advances in Neurochemistry pp 193–211Cite as

Substance P and Sensory Transmitter

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Part of the book series: Advances in Neurochemistry ((CORG,volume 2))

Abstract

Two papers that appeared in the 1930s had an important influence on later studies of sensory transmitters and they have particular relevance in the present chapter. Euler and Gaddum (1931), while studying the distribution of acetylcholine in different organs, found that the extracts of equine brain and intestine contain an unidentified vasodilator and smooth-muscle-contracting agent. This agent was later referred to as substance P (Chang and Gaddum, 1933; Gaddum and Schild, 1934) and was shown to be of peptide nature (Euler, 1936). For many years, however, the chemical structure of substance P as well as its physiological function remained unknown (see below).

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

    Masanori Otsuka

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  1. Masanori Otsuka
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Editors and Affiliations

  1. Mental Health Research Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA

    B. W. Agranoff

  2. Institute of Psychiatric Research and Department of Psychiatry and Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana, USA

    M. H. Aprison

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© 1977 Plenum Press, New York

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Otsuka, M. (1977). Substance P and Sensory Transmitter. In: Agranoff, B.W., Aprison, M.H. (eds) Advances in Neurochemistry. Advances in Neurochemistry, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8237-3_3

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  • DOI: https://doi.org/10.1007/978-1-4615-8237-3_3

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