DR. WERTHESSEN: As in most control systems there is probably a modulator or inhibitory mechanism in the arterial wall that prevents the ingress of too much fat. Where the supply of nutriment is scant, however, such inhibitory mechanisms are likely to be operating at a very low level, or not operative at all. Thus, it is easier to induce lipid deposition in the artery of a normally non-fat-eating animal, like a rabbit, than in a normally fat-eating animal, the dog. This may be akin to the situation observed among Japanese in Japan who had fewer myocardial infarctions than Japanese in Hawaii, while they, in turn, had fewer than those in the United States. The development of inhibitory controls may require generations and may very well be a key to genetic differences.
KeywordsCholesterol Level Serum Cholesterol Serum Triglyceride Fasting Triglyceride Cholesterol Esterase
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