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Pharmacology of Heart Cells During Ontogenesis

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Advances in General and Cellular Pharmacology

Abstract

The reactivity of the embryo heart to drugs has attracted considerable attention. There are several reasons that make cardiac tissue from embryonic and fetal animals advantageous for a systemic investigation of drug action. A study of when and how the heart develops responsiveness to selected chemical probes is an invaluable aid in defining the mechanism of action of drugs and how the mechanism is modified by environmental factors (intra- and extracellular). For example, drug action can be compared in the noninnervated and innervated heart. In this manner, the effects of innervation on receptor sensitivity for transmitter molecules can be examined without the use of surgical or pharmacological techniques to eliminate neural activity. A reasoned examination of the pharmacology of the developing heart necessarily involves a systematic study of the fundamental features of cardiac development itself. The reaction between a drug molecule and a cardiac cell depends upon an interaction with chemical recognition sites (receptors) whose synthesis and assembly have been accomplished at a specified time during ontogenesis. The receptors are associated with electrical (e.g., conductance) and mechanical (e.g., myofilament interaction) properties of the cell; therefore, drug action will produce a change in the electrical and mechanical activity of the cell. Heart cells from embryonic and fetal animals also lend themselves easily to study under in vitro conditions in cell or organ culture.

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Authors and Affiliations

  1. Department of Pharmacology, University of Connecticut Health Center, Farmington, Connecticut, 06032, USA

    Achilles J. Pappano

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  1. Duke University Medical Center, USA

    Toshio Narahashi

  2. University of Pennsylvania School of Medicine, USA

    C. Paul Bianchi

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© 1976 Plenum Press, New York

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Pappano, A.J. (1976). Pharmacology of Heart Cells During Ontogenesis. In: Narahashi, T., Bianchi, C.P. (eds) Advances in General and Cellular Pharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8198-7_3

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  • DOI: https://doi.org/10.1007/978-1-4615-8198-7_3

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