Abstract
Elastic fibers are components of virtually all mammalian connective tissues. Elastin, the major protein component of elastic fibers, has unique elastomeric properties which provide the reversible deformability that is critical to arterial vessels, lungs and skin. Without such a property, the structural integrity and function of these tissues would be greatly impaired.
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References
Dietz HC, Cutting GR, Pyeritz RE, Maslen CL, Sakai LY, Corson GM, EG, Hamosh A, Nanthakumar EJ, Curristin SM, Stetten G, Meyers DA and Francomano CA (1991): Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene. Nature (Lond) 352: 337–339.
Fahrenbach WH, Sandberg LB and Cleary EG (1966): Ultrastructural studies on early elastogenesis. Anat Rec 155: 563–576.
Gibson MA and Cleary EG (1987): The immunohistochemical localization of microfibril-associated glycoprotein (MAGP) in elastic and non-elastic tissues. Immunol Cell Biol 65: 345–356.
Gibson MA, Hughes JL, Fanning JC and Cleary EG (1986): The major antigen of elastin-associated microfibrils is a 31 kDa glycoprotein. J Biol Chem 261: 11429–11436.
Gibson MA, Kumaratilake JS and Cleary EG (1989): The protein components of the 12-nanometer microfibrils of elastic and non-elastic tissues. J Biol Chem 264: 4590–4598.
Gibson MA, Sandberg LB, Grosso LE and Cleary EG (1991): Complementary DNA cloning establishes microfibril-associated glycoprotein (MAGP) to be a discrete component of the elastin-associated microfibrils. J Biol Chem 266: 7596–7601.
Greenlee TKJ, Ross R and Hartman IL (1966): The fine structure of elastic fibers. J Cell Biol 30: 59–71.
Hoeve CAT (1974): The elastic properties of elastin. Biopolymers 13: 677–686.
Horrigan SK, Rich CB, Streeten BW, Li ZY and Foster JA (1992): Characterization of an associated microfibril protein through recombinant DNA techniques. J Biol Chem 267: 10087–10095.
Jaques A and Serafini-Fracassini A (1986): Immunolocalisation of a 35K structural glycoprotein to elastin-associated microfibrils. J Ultrastruct Mol Struct Res 95: 218–227.
Kagan HM and Trackman PC (1991): Properties and function of lysyl oxidase. Am J Respir Cell Molec Biol 5: 206–210.
Kuhn CI, Yu SY, Chraplyvy M, Linder HE and Senior RM (1976): The induction of emphysema with elastase. II. Changes in connective tissue. Lab Invest 34: 372–380.
Kumaratilake JS, Gibson MA, Fanning JC and Cleary EG (1989): The tissue distribution of microfibrils reacting with a monospecific antibody to MAGP, the major glycoprotein antigen of elastin-associated microfibrils. Eur J Cell Biol 50: 117–127.
Lee B, Goodfrey M, Vitale E, Hori H, Mattei M-G, Sarfarazi M, Tsipouras P, Ramirez F and Hollister DW (1991): Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes. Nature (Lond) 352: 330–334.
Lefevre M and Rucker RB (1980): Aorta elastin turnover in normal and hypercholesterolemic Japanese quail. Biochim Biophys Acta 630: 519–529.
Low FN (1962): Microfibrils: Fine filamentous components of the tissue space. Anat Rec 142: 131–137.
Maslen CL, Corson GM, Maddox BK, Glanville RW and Sakai LY (1991): Partial sequence of a candidate gene for the Marfan syndrome. Nature (Lond) 352: 334–337.
McKusick VA (1991): The defect in Marfan syndrome. Nature (Lond) 352: 279–281.
Mecham RP, Hinek A, Cleary EG, Kucich U, Lee SJ and Rosenbloom J (1988): Development of immunoreagents to ciliary zonules that react with protein components of elastic fiber microfibrils and with elastin-producing cells. Biochem Biophys Res Commun 151: 822–826.
Mecham RP, Hinek A, Entwistle R, Wrenn DS, Griffm GL and Senior RM (1989): Elastin binds to a multifunctional 67 kD peripheral membrane protein. Biochemistry 28: 3716–3722.
Mecham RP, Whitehouse L, Hay M, Hinek A and Sheetz M (1991a): Ligand affinity of the 67 kDa elastin/laminin binding protein is modulated by the protein’s lectin domain: Visualization of elastin/laminin receptor complexes with gold-tagged ligands. J Cell Biol 113: 187–194.
Mecham RP, Stenmark KR and Parks WC (199lb): Connective tissue production by vascular smooth muscle in development and disease. Chest 99: 43S - 47S.
Ross R (1971): The smooth muscle cell. U. Growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol 50: 172–186.
Ross R and Bornstein P (1969): The elastic fiber. I. The separation and partial characterization of its macromolecular components. J Cell Biol 40: 366–381.
Rucker RB and Dubick MA (1984): Elastin metabolism and chemistry: potential roles in lung development and structure. Environ Health Perspect 53: 179–191.
Rucker RB and Tinker D (1977): Structure and metabolism of arterial elastin. Int Rev Exp Pathol 17: 1–47.
Sakai LY, Keene DR and Engvall E (1986): Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. J Cell Biol 103: 2499–2509.
Serafini-Fracassini A, Ventrella G, Field MJ, Hinnie J, Onyezili NI and Griffiths R (1981): Characterization Of a structural glycoprotein from bovine ligamentum nuchae exhibiting dual amine oxidase activity. Biochemistry 20: 5424–5429.
Shapiro SD, Endicott SK, Province MA, Pierce JA and Campbell ET (1991): Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J Clin Invest 87: 1828–1834.
Streeten BW and Gibson SA (1988): Identification of extractable proteins from the bovine ocular zonule: Major zonular antigens of 32 kD and 250 kD. Current Eye Res 7: 139–146.
Urry DW (1983): What is elastin; what is not. Ultrastruct Pathol 4: 227–251.
Waksaki H and Ooshima A (1990): Immunohistochemical localization of lysyl oxidase with monoclonal antibodies. Lab Invest 63: 377–384.
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© 1993 Birkhäuser Boston
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Davis, E.C., Mecham, R.P. (1993). Elastic Fiber Organization. In: Bell, E. (eds) Tissue Engineering. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4615-8186-4_3
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DOI: https://doi.org/10.1007/978-1-4615-8186-4_3
Publisher Name: Birkhäuser, Boston, MA
Print ISBN: 978-1-4615-8188-8
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