Abstract
Autogenous vessels, primarily saphenous veins, remain the “gold standard” for arterial grafting (Kent et al, 1989); however, they do not function as normal blood vessels immediately after surgery. In both animals (Jones et al, 1973; Fonkalsrud et al, 1978) and humans (Unni et al, 1974; Spray AND Roberts, 1977) there is extensive endothelial and smooth muscle cell necrosis, a platelet-fibrin deposit on the intimal surface, and medial edema shortly after grafting. A vein graft functions as a scaffold for extensive remodeling resulting in an artery-like structure with an endothelium and smooth muscle cell media after a period of weeks to months. Thus cardiovascular surgeons have, perhaps unknowingly, been successfully practicing tissue engineering for several decades. Similarly, other biological materials, such as the submucosa of the small intestine, can also serve as scaffolds for remodeling and arterialization (Badylak et al, 1989; Sandusky et al, 1992).
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© 1993 Birkhäuser Boston
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Weinberg, C.B. et al. (1993). Matrix Engineering: Remodeling of Dense Fibrillar Collagen Vascular Grafts in Vivo. In: Bell, E. (eds) Tissue Engineering. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4615-8186-4_18
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DOI: https://doi.org/10.1007/978-1-4615-8186-4_18
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