Abstract
The Phase III clinical trial is a randomized, comparative, often multi-institutional study addressed to a quantitative question. It is the cadillac of clinical trials. When properly applied, it is highly effective in comparing new treatment and standard (control) therapy.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fisher B, Redmond CK, Wolmark N, et al. Longterm results from NSABP trials of adjuvant therapy for breast cancer. In: Salmon, SE, ed. Adjuvant Chemotherapy of Cancer, V. Orlando: Grane and Stratton. 1987: 283–295.
Bonadonna G, Brusamolia E, Rossi A, et al. Combination chemotherapy as adjuvant treatment in opearble breast cancer. N Eng J Med 1976; 294: 415.
Zelen M. The theory and practice of clinical trials. In: Holland, Frei, Bast, Kufe, Morton, Weichselbaum, Williams and Wilkins. Cancer Medicine, 3rd ed. 1992: 340–361.
Goldin A, Venditti J, Humphreys SR, et al. Influence of the concentration of leukemic inoculum on the effectiveness of treatment. Science 1956; 123: 840.
Early Breast Cancer Trialists Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic and immune therapy. Lancet 1992; 339:1–15, 72–85.
Goorin A, Abelson H, Frei E III. Osteosarcoma: Fifteen years later. N Eng J Med 1985; 313: 1637–1643.
Wood W, Korzan A, Cooper R, et al. Dose and dose intensity for adjuvant chemotherapy for stage II, node positive, breast cancer. N Eng J Med 1994; 330: 1253.
Fisher, R, Gaynor ER, Dahlberg S, et al. Comparison of standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non—Hodgkin’s lymphoma. N Eng J Med 1993; 328: 1002–1006.
Frei E III, Freireich EJ. The clinical cancer researcher—still an embattled species. J Clin Onc 1993; 11: 1693–1671.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Frei, E. (1997). The Phase III Cancer Clinical Trial. In: Teicher, B.A. (eds) Anticancer Drug Development Guide. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4615-8152-9_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-8152-9_15
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4615-8154-3
Online ISBN: 978-1-4615-8152-9
eBook Packages: Springer Book Archive