Abstract
The release of vasopressin (VP) from the neural lobe occurs in response to action potentials, which are generated at the perikaryon and propagated down the axon to the nerve terminal located in the posterior pituitary. The generation of electrical signals and subsequent hormonal release occurs in response to synaptic release of neuroactive agents from nerve terminals in the hypothalamus. VP release may also be regulated by neuroactive agents released from nerve terminals in the posterior pituitary. Figure 1 summarizes our current knowledge of the neuronal projections and identified transmitters to the supraoptic nucleus (SON) and neural lobe. This literature is reviewed in detail by Swanson and Sawchenko (1983) (see also Chapter 1, this volume). It is apparent that this anatomical evidence implicates numerous neurotransmitters and neuropeptides as candidates for regulating hormonal release from the neural lobe. An even greater number of neuroactive substances have been localized to the paraventricular nucleus (PVN), but the complexity of that nucleus suggests that these additional agents may subserve functions other than regulation of hormonal release from the neurohypophysis. Thus, this chapter concentrates on neuroactive substances localized in SON and the neural lobe in evaluating the physiological regulation of VP release from the neural lobe by neurotransmitters and neuropeptides.
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© 1987 Plenum Press, New York
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Sladek, C.D., Armstrong, W.E. (1987). Effect of Neurotransmitters and Neuropeptides on Vasopressin Release. In: Gash, D.M., Boer, G.J. (eds) Vasopressin. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8129-1_7
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