Abstract
In the guinea pig it is difficult to maintain a viable fetus during the three day period required for maternal metabolites to stabilize following anesthesia and surgery (Sparks et al., 1981). Therefore, it is necessary to study fetal respiration in the anesthetized animal (Moll & Kastendieck, 1978; Grønlund and Carter, 1982; Girard et al., 1983; Christensen et al., 1986). Maternal placental blood flow is reduced during anesthesia and surgery. In unanesthetized guinea pigs with chronically implanted catheters, Peeters et al. (1982) found a placental blood flow of 15 ml/min, approximately twice as high as that determined after fetal surgery during pentobarbital anesthesia (Grønlund and Carter, 1982). This reduction in flow is due to hypotension produced by a reduction in cardiac output (Peeters et al., 1982).
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© 1988 University of Rochester
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Carter, A.M., Christensen, P., Grønlund, J. (1988). A Theoretical Analysis of the Influence of Maternal and Fetal Blood Flow on Placental Gas Exchange in the Guinea Pig. In: Kaufmann, P., Miller, R.K. (eds) Placental Vascularization and Blood Flow. Trophoblast Research, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8109-3_18
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DOI: https://doi.org/10.1007/978-1-4615-8109-3_18
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