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Immunobiology of EBV-Associated Cancers

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The Herpesviruses

Part of the book series: The Viruses ((VIRS))

Abstract

The Epstein-Barr virus (EBV) has been studied as a candidate human cancer virus since its discovery in 1964. The herpesvirus was first isolated from a lymphoblastoid cell line established from an African Burkitt’s lymphoma (BL) biopsy thereby stimulating interest in the role of this virus in the etiology of this disease (Epstein et al., 1964). Subsequent studies by the Henle and Henle conclusively demonstrated that EBV was the causative agent of heterophil-positive infectious mononucleosis (Henle et ah, 1968; Henle and Henle, 1978). In addition, results were published by Old and associates suggesting that EBV might be a factor in the etiology of nasopharyngeal carcinoma (NPC), a high-incidence cancer in Africa and Southeast Asia (Old et ah, 1966). These initial disease associations, established largely from seroepidemiological findings, stimulated extensive research on the possible role of this virus in the etiology of these diseases as well as toward identifying other neoplastic disease states in which this virus might play an etiological role. This resulted in publications suggesting that EBV might also be an important cofactor in the etiology of such diseases such as Hodgkin’s disease and CLL (Johannson et al., 1970, 1971). In addition, this virus has been implicated as a factor in the etiology of B-cell lymphomas, which have been occurring at a relatively high frequency in patients with genetic-associated or drug-induced immunodeficiency states (Purtilo, 1976; Klein and Purtilo, 1981). More recently, results have been reported suggesting that EBV might also be a causative factor of Kaposi’s sarcoma in patients with AIDS (Quinnan et al., 1984). Thus, from the etiological point of view, this virus continues to be of interest in relation to the etiology of certain types of human cancers.

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Authors and Affiliations

  1. Section of Microbiology, Mayo Foundation, Rochester, Minnesota, 55905, USA

    Gary R. Pearson

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  1. Gary R. Pearson
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Editors and Affiliations

  1. University of Chicago, Chicago, Illinois, USA

    Bernard Roizman

  2. Sloan-Kettering Institute for Cancer Research, New York, New York, USA

    Carlos Lopez

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© 1985 Plenum Press, New York

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Pearson, G.R. (1985). Immunobiology of EBV-Associated Cancers. In: Roizman, B., Lopez, C. (eds) The Herpesviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8021-8_9

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  • DOI: https://doi.org/10.1007/978-1-4615-8021-8_9

  • Publisher Name: Springer, Boston, MA

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