Abstract
The normal host has a series of defense mechanisms that participate in sequestering and clearing invading viral pathogens (Allison, 1974). The defense systems involved fall into two major categories: Natural resistance mechanisms are immediately available to respond to the microorganism and require no prior exposure to foreign antigen in order to be operative; adaptive immune mechanisms require presensitization and are not active until several days after primary virus infection. The adaptive immune response against herpesvirus infections consists of the antibody response (discussed in Chapter 3 by Norrild) and the cell-mediated immune response (discussed in Chapter 4 by Nash, Leung, and Wildy). This chapter will focus on the role of natural resistance mechanisms in defense against herpes simplex virus (HSV) infections. The specific systems to be discussed include macrophages, natural killer (NK) cells, and interferon (IFN).
Keywords
- Natural Killer Cell
- Herpes Simplex Virus Type
- Herpes Simplex Virus Infection
- Genetic Resistance
- Large Granular Lymphocyte
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© 1985 Plenum Press, New York
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Lopez, C. (1985). Natural Resistance Mechanisms in Herpes Simplex Virus Infections. In: Roizman, B., Lopez, C. (eds) The Herpesviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8021-8_2
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