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Effects of Immunopotentiating and Immunomodulating Agents on Experimental and Clinical Herpesvirus Infections

  • Chapter
The Herpesviruses

Part of the book series: The Viruses ((VIRS))

Abstract

As pointed out by Ching and Lopez (1979), patients with some types of immunodeficiency disorders, newborn infants, and patients treated with cytotoxic immunosuppressive drugs, either for cancer or for organ transplantation, are prone to unusually severe infections with herpesviruses (herpes simplex, cytomegalovirus, varicella-zoster). Herpes simplex virus (HSV) and cytomegalovirus (CMV) are a common cause of morbidity and mortality in bone marrow, renal, and cardiac allograft recipients. A defect in cell-mediated immunity to CMV has been reported both in children who excrete CMV in the first year of life and in their mothers (Starr et al., 1979). It appears reasonable therefore to assume that restoration of the immune capacity by appropriate immunopotentiating agents might be a way to control the severity of herpesvirus infections in immuno-deficient patients and, by some stretch of the imagination, that such drugs might even be useful in the management of herpesvirus infections in immunologically normal subjects.

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Authors and Affiliations

  1. Rhône-Poulenc Santé, Centre de Recherches de Vitry, 94407, Vitry-sur-Seine, France

    Georges H. Werner & Aurelio Zerial

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  1. Georges H. Werner
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  2. Aurelio Zerial
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  1. University of Chicago, Chicago, Illinois, USA

    Bernard Roizman

  2. Sloan-Kettering Institute for Cancer Research, New York, New York, USA

    Carlos Lopez

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Werner, G.H., Zerial, A. (1985). Effects of Immunopotentiating and Immunomodulating Agents on Experimental and Clinical Herpesvirus Infections. In: Roizman, B., Lopez, C. (eds) The Herpesviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8021-8_19

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  • DOI: https://doi.org/10.1007/978-1-4615-8021-8_19

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