Abstract
The increased knowledge of the properties of membrane lipids (Ansell et al., 1973) and of lipid-protein interactions (Singer, 1971; Lenaz, 1973, 1977; Vanderkooi, G., 1974) allows a better understanding of the role of lipids in membrane structure and functions. Nevertheless, a unifying picture of such a role is lacking, and it is often tacitly assumed that lipids have different roles; this is indeed the main conclusion emerging from analysis of the literature. In fact, lipids in membranes have different functions, affecting enzymic activity positively or negatively, being determinants of permeability properties and transport and being involved in the action of membrane binding sites and receptors. Moreover, they are determinants of membrane phenomena involving fusion processes (e.g., cell movement, pinocytosis, cell division, cell adhesion, secretion). In such functions, lipids may be specific or not. The physical state of a lipid, besides the specific chemical nature of certain groups, appears to be very important in its functions. It seems therefore appropriate to assign to lipids many different roles.
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Abbreviations
- (ANS):
-
1-anilinonaphthalene 8-sulfonate
- (BDH):
-
β-hydroxybutyrate dehydrogenase
- (cAMP):
-
cyclic 3′,5′-AMP
- (CD):
-
circular dichroism
- (cyt):
-
cytochrome
- (DML):
-
dimyristoyl lecithin
- (DOL):
-
dioleyl lecithin
- (DPL):
-
dipalmitoyl lecithin
- (DSC):
-
differential scanning calorimetry
- (EFA):
-
essential fatty acid(s)
- (EM):
-
electron microscopy
- (ESR):
-
electron spin resonance
- (excimer):
-
excited dimer
- (GH):
-
growth hormone
- (HDL):
-
highdensity lipoproteins
- (NMR):
-
nuclear magnetic resonance
- (PC):
-
phosphatidylcholine (lecithin)
- (PE):
-
phosphatidylethanolamine
- (PG):
-
prostaglandin
- (PS):
-
phosphatidylserine
- (TEMPO):
-
2,2,-6,6-tetramethyl piperidine-1-oxyl
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Lenaz, G. (1979). The Role of Lipids in the Structure and Function of Membranes. In: Roodyn, D.B. (eds) Subcellular Biochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7945-8_5
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