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The Renal Circulation: Physiology and Hormonal Control

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Abstract

Although much attention has been paid to the immunologic aspects of kidney disease (Germuth and Rodriguez, 1973; McCluskey, 1974; Wilson and Dixon, 1974), it is clear that many of the more common afflictions have a predominantly circulatory rather than an immunologic basis. Vascular abnormalities and altered renal perfusion play a key role in the renal disorders associated with arteriosclerosis, hypertension, shock, liver disease, sepsis, trauma, diabetes, and the toxic effects of certain drugs (Barger, 1966; Siper-stein et al., 1968; Hollenberg, 1973; Hollenberg and Adams, 1974). Disturbed renal hemodynamics are pathogenetically important even in disorders of undisputed immunologic origin, such as renal transplant rejection (Hollenberg et al., 1972).

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References

  • Altman, P.L., and Dittmer, D.S. (eds.), 1962, “Growth Including Reproduction and Morphological Development,” Federation of American Societies Experimental Biology, Washington, D.C., p. 365.

    Google Scholar 

  • Andreucci, V.E., Dal Canton, A., and Corradi, A., 1975, The role of the efferent arteriole in cortical renal hemodynamics: A micropuncture study, Kidney Int. 7:187.

    Google Scholar 

  • Änggård, E., and Bergström, S., 1963, Biologic effects of an unsaturated tryhydroxy acid (PGF) from normal swine lung, Acta Physiol. Scand. 58:1.

    PubMed  Google Scholar 

  • Änggård, E., Bohman, S.O., Griffin, J.E. III, Larsson, C., and Maunsbach, A.B., 1972, Subcellular localization of the prostaglandin system in the rabbit renal papilla, Acta Physiol. Scand. 84:231.

    PubMed  Google Scholar 

  • Arendshorst, W.J., Finn, W.F., and Gottschalk, C.W., 1975, Auto-regulation of blood flow in the rat kidney, Am. J. Physiol. 228:127.

    PubMed  CAS  Google Scholar 

  • Attallah, A.A., and Lee, J.B., 1973, Specific binding sites in the rabbit kidney for prostaglandin A, Prostaglandins 4:703.

    PubMed  CAS  Google Scholar 

  • Attallah, A.A., Payakkapan, W., Lee, J.B., Carr, A., and Brazelton, E., 1974, PGA: Fact, not artifact, Prostaglandins 5:69.

    PubMed  CAS  Google Scholar 

  • Aukland, K., 1967, Study of renal circulation with inert gas: Measurements in tissue, in “Proceedings of the Third International Congress of Nephrology” (Washington, D.C., 1966) Vol. I: Physiology (G.E. Schreiner, ed.) pp. 188–200, S. Karger, Basel.

    Google Scholar 

  • Baehler, R.W., Catanzaro, A.J., Stein, J.H., and Hunter, W., 1973, The radiolabeled frog red blood cell: A new marker of cortical blood flow distribution in the kidney of the dog, Circ. Res. 32:718.

    PubMed  CAS  Google Scholar 

  • Bagdasarian, A., Lahiri, B., and Colman, R.W., 1973, Origin of the high molecular weight activator of prekallikrein, J. Biol. Chem. 248:7742.

    PubMed  CAS  Google Scholar 

  • Bakhle, Y.S., 1974, Converting enzyme in vitro measurement and properties, in “Handbook of Experimental Pharmacology, Vol. 37, Angiotensin” (I.H. Page and F.M. Bumpus, eds.), pp. 41–80, Springer-Verlag, New York.

    Google Scholar 

  • Bankir, L., Farman, N., Grünfeld, J.-P., Huet de la Tour, E., and Funck-Brentano, J.-L., 1973, Radioactive microsphere distribution and single glomerular blood flow in the normal rabbit kidney, Pflug. Arch. 342:111.

    CAS  Google Scholar 

  • Barac, G., 1957, Effet renal de la bradykinine chez le Chien, C.R. Soc. Biol. (Paris) 151:1771.

    CAS  Google Scholar 

  • Barajas, L., and Latta, H., 1967, Structure of the juxtaglomerular apparatus, Circ. Res. 20/21 (Suppl. II):15.

    Google Scholar 

  • Barer, G.R., 1963, The action of vasopressin, a vasopressin analog (PLV2), oxytocin, angiotensin, brakykinin and theophyline ethylene diamine on renal blood flood in the anesthetized cat, J. Physiol. 169:62.

    CAS  Google Scholar 

  • Barger, A.C., 1966, Renal hemodynamic factors in congestive heart failure, Ann. N.Y. Acad. Sci. 139:276.

    PubMed  CAS  Google Scholar 

  • Barger, A.C., and Herd, J.A., 1973, Renal vascular anatomy and distribution of blood flow, in “Handbook of Physiology, Section 8, Renal Physiology,” (J. Orloff and R.W. Berliner, eds.) pp. 249–313, Amer. Physiol. Soc, Washington.

    Google Scholar 

  • Beck, N., Kim, K.S., and Davis, B.B., 1975, Catecholamine-dependent cyclic adenosine monophosphate and renin in the dog kidney, Circ. Res. 36:401.

    PubMed  CAS  Google Scholar 

  • Bell, E.T., 1950, “Renal Diseases,” 2nd Edition, Lea and Febiger, Philadelphia, p. 337.

    Google Scholar 

  • Bell, R.D., Keyl, M.J., Shrader, F.R., Jones, E., and Henry, L.P., 1968, Renal lymphatics: The internal distribution, Nephron 5:454.

    PubMed  CAS  Google Scholar 

  • Bell, R.D., Parry, W.L., and Grundy, W.G., 1973, Renal lymph sodium and potassium concentrations following renal vasodilation, Proc. Soc. Exp. Biol. Med. 143:499.

    PubMed  CAS  Google Scholar 

  • Bell, R.D., Sinclair, R.J., and Parry, W.L., 1975, The effects of indomethacin on autoregulation and the renal response to hemorrhage, Circ. Shock 2:57.

    CAS  Google Scholar 

  • Belleau, L.J., and Earley, L.E., 1967, Autoregulation of renal blood flow in the presence of angiotensin infusion, Amer. J. Physiol. 213:1590.

    PubMed  CAS  Google Scholar 

  • Bergström, S., and Samuelsson, B., 1965, Prostaglandins, Ann. Rev. Biochem. 34:101.

    Google Scholar 

  • Bergström, S., and Sjövall, J., 1960a, The isolation of prostaglandin F from sheep prostate glands, Acta Chem. Scand. 14:1693.

    Google Scholar 

  • Bergström, S., and Sjövall, J., 1960b, The isolation of prostaglandin E from sheep prostate glands, Acta. Chem. Scand. 14:1701.

    Google Scholar 

  • Berkowitz, H.D., Galvin, C.C., and Miller, L.D., 1974, The control of renal cortical perfusion by the renin angiotensin system, Ann. Surg. 179:238.

    PubMed  CAS  Google Scholar 

  • Bianchi, A., De Schaepdryver, A.F., De Vleeschhouver, G.R., and Preziosi, P., 1960, On the pharmacology of synthetic hyper-tensine, Arch. Int. Pharmacodyn. 124:21.

    PubMed  CAS  Google Scholar 

  • Bing, J., Poulson, K., and Markussen, J., 1974, The ability of various insulins and insulin fragments to inhibit the angiotensin I converting enzyme, Acta Path. Microbiol. Scand., Sect. A. 82:777.

    CAS  Google Scholar 

  • Biron, P., Campeau, L., and David, P., 1969, Fate of angiotensin I and II in the human pulmonary circulation, Amer. J. Cardiol. 24:544.

    PubMed  CAS  Google Scholar 

  • Biron, P., Meyer, P., and Panisset, V.C., 1968, Removal of angiotensins from the systemic circulation, Canad. J. Physiol. Pharmacol. 46:175.

    CAS  Google Scholar 

  • Bock, K.D., Dengler, H., Krecke, H.J., and Reichel, G., 1958, Untersuchurgen über die Wirkung von synthetischem Hypertensin II auf Elektrolythaushalt, Nierenfunktion und Kreislauf beim Menschen, Klin. Woch. 36:808.

    CAS  Google Scholar 

  • Bohr, D.F., and Uchida, E., 1967, Individualities of vascular smooth muscle in response to angiotensin, Circ. Res. 21 (Suppl. II):135.

    PubMed  Google Scholar 

  • Boonjarern, S., Wertenfelder, C., Arruda, J.A.L., Lockwood, R., and Kurtzman, N.A., 1974, Distribution of renal cortical blood flow (CBF) in congestive heart failure (CHF) with radioactive microspheres, (MS), Kidney Int. 6:26A.

    Google Scholar 

  • Boucher, R., Asselin, J., and Genest, J., 1974, A new enzyme leading to the direct formation of angiotensin II, Circ. Res. 34 (Suppl. I):203.

    Google Scholar 

  • Boucher, R., Saidi, M., and Genest, J., 1972, A new “angiotensin I converting enzyme” system in “Hypertension 72” (J. Genest and E. Koiw, eds.) pp. 512–523, Springer-Verlag, New York.

    Google Scholar 

  • Boyd, G.W., Landon, J., and Peart, W.S., 1969, The radioimmunoassay of angiotensin II, Proc. Roy. Soc. B. 173:327.

    CAS  Google Scholar 

  • Bradley, S.E., Stéphan, F., Coelho, J.B., and Réville, P., 1974, The thyroid and the kidney, Kidney Int. 6:346.

    PubMed  CAS  Google Scholar 

  • Bras, G., 1969, Age-associated kidney lesions in the rat, J. Infect. Dis. 120:131.

    PubMed  CAS  Google Scholar 

  • Braun-Menendez, E., Fasciolo, J.C., Leloir, L.F., Munoz, V.M., and Taquini, A.C., 1946, “Renal Hypertension,” Charles C. Thomas, Springfield, pp. 134–135.

    Google Scholar 

  • Braun-Menendez, E., Fasciolo, J.C., Leloir, L.F., and Munoz, J.M., 1940, The substance causing renal hypertension, J. Physiol. 98:283.

    PubMed  CAS  Google Scholar 

  • Brenner, B.M., Deen, W.M., and Robertson, C.R., 1974, The physiological basis of glomerular ultrafiltration, in “MTP International Review of Science, Physiology Series 1, Vol. 6, Kidney and Urinary Tract Physiology,” (K. Thurau, ed.), pp. 335–356, Butterworths, London.

    Google Scholar 

  • Brody, M.J., and Kadowitz, P.J., 1974, Prostaglandins as modulators of the autonomic nervous system, Fed. Proc. 33:48.

    PubMed  CAS  Google Scholar 

  • Brown, J.J., Davies, D.L., Lever, A.F., Parker, R., and Robertson, J.I.S., 1965, The assay of renin in single glomeruli in the normal rabbit and the appearance of the juxtaglomerular apparatus, J. Physiol. 176:418.

    CAS  Google Scholar 

  • Brunner, H.R., Baer, L., and Sealey, J.E., Ledingham, J.G.G., and Laragh, J.H., 1970, The influence of potassium administration and of potassium deprivation on plasma renin in normal and hypertensive subjects, J. Clin. Invest. 49:2128.

    PubMed  CAS  Google Scholar 

  • Bruns, F.J., Alexander, E.A., Riley, A.L., and Levinsky, N.G., 1974, Superficial and juxtamedullary nephron function during saline loading in the dog, J. Clin. Invest. 53:971.

    PubMed  CAS  Google Scholar 

  • Burton-Optiz, R., and Lucas, D.R., 1911, The blood supply of the kidney. V. The influence of the vagus nerve on the vascularity of the left organ, J. Exp. Med. 13:308.

    Google Scholar 

  • Burzynski, S.R., Ungar, A.L., and Lubanski, E., 1974, Biologically active peptides in human urine. II. Effect on intestinal smooth muscle and heart, Physiol. Chem. Physics 6:457.

    CAS  Google Scholar 

  • Byers, B.D., Deen, W.M., Robertson, C.R., and Brenner, B.M., 1975, Dynamics of glomerular ultrafiltration in the rat. VIII. Effects of hematocrit, Circ. Res. 36:425.

    Google Scholar 

  • Cain, M.D., Catt, K.J., Coghlan, J.P., and Blair-West, J.R., 1970, Evaluation of angiotensin II metabolism in sheep by radioimmunoassay, Endocrinology 86:955.

    PubMed  CAS  Google Scholar 

  • Carvalho, I.F., and Diniz, C.R., 1963, Kininogenin in rat kidney tissue, Ciencia Cult. (S. Paulo) 15:286.

    Google Scholar 

  • Carvalho, I.F., and Diniz, C.R., 1964, Cellular localization of renin and kininogenin, Ciencia Cult. (S. Paulo) 16:263.

    Google Scholar 

  • Caton, M.P.L., 1973, Chemical structure and availability, in “The Prostaglandins” (M.F. Cuthbert, ed.) pp. 1–22, Heinemann, London.

    Google Scholar 

  • Chang, L.C.T., Splawinski, J.A., Oates, J.A., and Nies, A.S., 1975, Enhanced renal prostaglandin production in the dog. II. Effects on intrarenal hemodynamics, Circ. Res. 36:204.

    PubMed  CAS  Google Scholar 

  • Chiang, T.S., Erdös, E.G., Miwa, I., Tague, L.L., and Coalson, J.J., 1968, Isolation from a salivary gland of granules containing renin and kallikrein, Circ. Res. 23:507.

    PubMed  CAS  Google Scholar 

  • Christy, N.P., and Shaver, J.C., 1974, Estrogens and the kidney, Kidney Int. 6:366.

    PubMed  CAS  Google Scholar 

  • Collier, J.G., Herman, A.G., and Vane, J.R., 1973, Appearance of prostaglandins in the renal venous blood of dogs in response to acute systemic hypotension produced by bleeding or endotoxin, J. Physiol. 230:19P.

    Google Scholar 

  • Colman, R.W., 1974, Formation of human plasma kinin, New Engl. J. Med. 291:509.

    PubMed  CAS  Google Scholar 

  • Cook, W.F., 1971, Cellular localization of renins in “Kidney Hormones” (J.W. Fisher, ed.), Academic Press, New York.

    Google Scholar 

  • Cook, W.F., Gordon, D.B., and Peart, W.S., 1956, The location of renin in the rabbit kidney, J. Physiol. 135:46P.

    Google Scholar 

  • Cooke, C.R., Brown, T.C., Zacherle, B.J., and Walker, W.G., 1970, The effect of altered sodium concentration in the distal nephron segments on renin release, J. Clin. Invest. 49:1630.

    PubMed  CAS  Google Scholar 

  • Crowshaw, K., 1971, Prostaglandin biosynthesis from endogenous precursors in rabbit kidney, Nature, New Biol. 231:240.

    CAS  Google Scholar 

  • Crowshaw, K., 1973, The incorporation of [1-14C] arachidonic acid into the lipids of rabbit renal slices and conversion to prostaglandins E2 and F, Prostaglandins 3:607.

    PubMed  CAS  Google Scholar 

  • Dakhill, T., and Vogt, W., 1962, Hydroperoxyde als Thäges der darmerregenden Wirkung hochungesättigen Fettsäuren, Arch. Exp. Pathol. Pharmakol. 243:174.

    Google Scholar 

  • Dance, P., Lloyd, S., and Pickford, M., 1959, The effects of stil-bestrol on the renal activity of conscious dogs, J. Physiol. 145:225.

    PubMed  CAS  Google Scholar 

  • Danon, A., and Chang, L.C.T., 1973, Release of prostaglandins from rat renal papilla in vitro: Effects of arachidonic acid and angiotensin II, Fed. Proc. 32:788.

    Google Scholar 

  • Darmady, E.M., 1974, Transplantation and the aging kidney, Lancet 2:1046.

    PubMed  CAS  Google Scholar 

  • Darmady, E.M., Offer, J., and Woodhouse, M.A., 1973, The parameters of the aging kidney, J. Pathol. 109:195.

    PubMed  CAS  Google Scholar 

  • Davis, J.M., and Morgan, T.O., 1975, Renin release from the juxtaglomerular apparatus of the rat, Abstracts of Free Communications, VIth International Congress of Nephrology, June 8–12, 1975, Florence, Italy (Abstract 550).

    Google Scholar 

  • Davis, J.O., 1973, The control of renin release, Am. J. Med. 55:333.

    CAS  Google Scholar 

  • deBermudez, L., and Hayslett, J.P., 1972, Effect of methylprednis-olone on renal function and zonal distribution of blood flow in the rat, Circ. Res. 31:44.

    PubMed  CAS  Google Scholar 

  • De Bono, E., Lee, G. deJ., Mottram, F.R., Pickering, G.W., Brown, J.J., Keen, H., Peart, W.S., and Sanderson, P.H., 1963, The action of angiotensin in man, Clin. Sci. 25:123.

    Google Scholar 

  • Denko, C.W., Moskowitz, R.W., and Heinrich, G., 1972, Interrelated pharmacologic effects of prostaglandins and bradykinin, Pharmacology 8:353.

    PubMed  CAS  Google Scholar 

  • DiBona, G.F., 1971, Effect of mannitol diuresis and ureteral occlusion on distal tubular reabsorption, Amer. J. Physiol. 221:511.

    PubMed  CAS  Google Scholar 

  • Dignam, W.S., Voskian, J., and Assali, N.S., 1956, Effects of estrogens on renal hemodynamics and excretion of electrolytes in human subjects, J. Clin. Endocrinol. 16:1032.

    CAS  Google Scholar 

  • DiSalvo, J., and Fell, C., 1970, Effects of angiotensin on canine renal blood flow, Proc. Soc. Exp. Biol. Med. 133:1432.

    PubMed  CAS  Google Scholar 

  • DiSalvo, J., Peterson, A., Montefusco, C., and Menta, M., 1971, Intrarenal conversion of angiotensin I to angiotensin II in the dog, Circ. Res. 29:398.

    CAS  Google Scholar 

  • Doyle, A.E., Louis, W.J., Jerums, G., and Osborn, E.C., 1968, Metabolism and blood levels following infusion of a radioactive analog of angiotensin, Amer. J. Physiol. 215:164.

    PubMed  CAS  Google Scholar 

  • DuCharme, D.W., Weeks, J.R., and Montgomery, R.G., 1968, Studies on the mechanism of the hypertensive effect of prostaglandin F, J. Pharmacol. Exp. Ther. 160:1

    PubMed  CAS  Google Scholar 

  • Dunham, E.W., and Zimmerman, B.G., 1970, Release of prostaglandin-like material from dog kidney during nerve stimulation, Amer. J. Physiol. 219:1279.

    PubMed  CAS  Google Scholar 

  • Earley, L.E., and Friedler, R.M., 1966, The effects of combined renal vasodilation and pressor agents on renal hemodynamics and the tubular reabsorption of sodium, J. Clin. Invest. 45:542.

    PubMed  CAS  Google Scholar 

  • Edwards, W.G., Strong, C.G., and Hunt, J.C., 1969, A vasodepressor lipid resembling prostaglandin E2 (PGE2) in the renal venous blood of hypertensive patients, J. Lab. Clin. Med. 74:389.

    PubMed  CAS  Google Scholar 

  • Eide, I., Löyning, E., Aars, H., and Ikre, S., 1973, Autoregulation of renal blood flow in rabbits immunized with angiotensin II, Scand. J. Clin. Lab. Invest. 31:123.

    PubMed  CAS  Google Scholar 

  • Eliasson, R., and Risley, P.S., 1967, Potentiated response of isolated seminal vesicles to catecholamines and acetylcholine in the presence of prostaglandins, in “Prostaglandins”, Nobel Symposium, Vol. 2, (S. Bergstrom and B. Samuelsson, eds.) pp. 85–90, Interscience, New York.

    Google Scholar 

  • Eliseiva, Y.E., Orekhovich, V.N., Pavlikhina, L.V., and Aleseenko, L.P., 1971, Carboxycathepsin — a key regulatory component of two physiological systems involved in the regulation of blood pressure, Clin. Chim. Acta 31:413.

    Google Scholar 

  • Erdös, E.G., 1974, Discussion, Circ. Res. 34 (Suppl. I):210.

    Google Scholar 

  • Erdös, E.G., 1975, Angiotensin I converting enzyme, Circ. Res. 36:247.

    PubMed  Google Scholar 

  • Erdös, E.G., and Yang, H.Y.T., 1970, Kinases, in “Handbook of Experimental Pharmacology, Vol. 25, Bradykinin, kallidin, and kallikrein” (E.G. Erdös, ed). pp. 289–323, Springer-Verlag, New York.

    Google Scholar 

  • Eskildsen, P.C., 1973, Renin in different tissues, amniotic fluid and plasma of pregnant and non-pregnant rabbits, Acta. Pathol. Microbiol. Scand. Section A, 81:263.

    CAS  Google Scholar 

  • Faarup, P., 1971, Morphological aspects of the renin-angiotensin system, Acta Pathol. Microbiol. Scand. (A) Suppl. 222:1.

    Google Scholar 

  • Fasciolo, J.C., Leloir, L.F., Moñoz, J.M., and Braun-Menendez, E., 1940, On the specificity of renin, Science 92:554.

    PubMed  CAS  Google Scholar 

  • Feldberg, M., and Lewis, G.P., 1964, The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin, J. Physiol. 171:98.

    PubMed  CAS  Google Scholar 

  • Ferris, T.F., Gorden, P., and Mulrow, P.J., 1967, Rabbit uterus as a source of renin, Am. J. Physiol. 212:698.

    PubMed  CAS  Google Scholar 

  • Ferris, T.F., Stein, J.H., and Kauffman, J., 1972, Uterine blood flow and uterine renin secretion, J. Clin. Invest. 51:2827.

    PubMed  CAS  Google Scholar 

  • Fichman, M.P., Littenberg, G., Brooker, G., Brooker, G., and Horton, R., 1972, Effect of prostaglandin A1 on renal and adrenal function in man, Circ. Res. 31 (Suppl. II):19.

    PubMed  Google Scholar 

  • Fisher, R.D., Grünfeld, J.-P., and Barger, A.C., 1970, Intrarenal distribution of blood flow in diabetes insipidus: role of ADH, Am. J. Physiol. 219:1348.

    PubMed  CAS  Google Scholar 

  • Fitz, A., Boaz, D., and Wyatt, S., 1974, Studies of human lung angiotensin I converting enzyme, Circulation, 50 (Suppl. III):30.

    Google Scholar 

  • Flamenbaum, W., and Hamburger, R.J., 1974, Juxtaglomerular apparatus renin activity: Role of the renin-angiotensin system in acute renal failure, Circulation, 50, (Suppl. III):134.

    Google Scholar 

  • Flower, R.J., 1974, Discussion, in “Prostaglandin Synthetase Inhibitors,” (H.J. Robinson and J.R. Vane, eds.) p. 376, Raven Press, New York.

    Google Scholar 

  • Flower, R.J., Cheung, H.S., and Cushman, D.W., 1973, Quantitative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase (prostaglandin synthetase) system of bovine seminal vesicles, Prostaglandins 4:325.

    PubMed  CAS  Google Scholar 

  • Flower, R.J., Gryglewski, R., Herbaczynska-Cedro, K., and Vane, J.R., 1972, Effects of anti-inflammatory drugs on prostaglandin biosynthesis, Nature, New Biol. 238:104.

    CAS  Google Scholar 

  • Flower, R.J., and Vane, J.R., 1974, Commentary — Inhibition of prostaglandin biosynthesis, Biochem. Pharmacol. 23:1439.

    PubMed  CAS  Google Scholar 

  • Forster, R.P., and Mess, J.P., 1947, Effects of experimental neurogenic hypertension on renal blood flow and glomerular filtration rates in intact denervated kidneys of unanesthetized rabbits with adrenal glands demedullated, Am. J. Physiol. 150:534.

    PubMed  CAS  Google Scholar 

  • Fourcade, J.C., Navar, L.G., and Guyton, A.C., 1971, Possibility that angiotensin resulting from unilateral kidney disease affects contralateral renal function, Nephron 8:11.

    Google Scholar 

  • Fourman, J., and Moffat, D.B., 1971, “The Blood Vessels of the kidney,” Blackwell Scientific Publications, Oxford.

    Google Scholar 

  • Freed, T.A., Neal, M.P. Jr., and Vinik, M., 1968, The effect of bradykinin on renal arteriography, Amer. J. Roentgenol. 102:776.

    PubMed  CAS  Google Scholar 

  • Frey, E.K., 1929, Kreislaufhormon und innere Sekretion, Munch. med. Wschr. 76:1951.

    Google Scholar 

  • Frolich, V.C., Sweetman, B.J., Carr, K., Splawinski, J., Watson, V.T., Änggård, E., Oates, V.A., 1973, Occurrence of prostaglandins in human urine, Adv. Biosci. 9:321.

    Google Scholar 

  • Fülgraff, G., Brandenbusch, G., and Heintze, K., 1974, Dose response relation of the renal effects of PGA1 PGE2, and PGF in dogs, Prostaglandins 8:21.

    PubMed  Google Scholar 

  • Furuayama, T., Suzuki, C., Shioji, R., Saito, H., Maebashi, M., and Aida, M., 1967, Effect of angiotensin on renal function of the dog, Tohoku J. Exp. Med. 92:73.

    Google Scholar 

  • Gagnon, J.A., Keller, H.I., Kokotis, W., and Schrier, R.W., 1970, Analysis of role of renin-angiotensin system in autoregul-ation of glomerular filtration, Amer. J. Physiol. 219:491.

    PubMed  CAS  Google Scholar 

  • Gagnon, J.A., Rice, M.K., and Flamenbaum, W., 1974, Effect of angiotensin converting enzyme inhibition on renal auto-regulation, Proc. Soc. Exp. Biol. Med. 146:414.

    PubMed  CAS  Google Scholar 

  • Ganguli, M.D., Tobian, L., 1972, Renal medullary plasma flow in hypertension, Fed. Proc. 31:394, 1972.

    Google Scholar 

  • Genest, J., 1974, Renin and aldosterone in benign essential hypertension, Circulation, 50 (Suppl. III): 1.

    Google Scholar 

  • Germuth, F.G., and Rodriquez, E., 1973, “Immunopathology of the Renal Glomerulus,” Little, Brown and Co., Boston.

    Google Scholar 

  • Gimbrone, M.A., and Alexander, R.W., 1975, Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium, Science, 189:219, 1975.

    PubMed  CAS  Google Scholar 

  • Goldberg, L.I., Dollery, C.T., and Pentecost, B.L., 1965, Effects of intrarenal infusions of bradykinin and acetylcholine on renal blood flow in man, J. Clin. Invest. 44:1052.

    Google Scholar 

  • Goormaghtigh, N., 1932, Les segments neuro-myarteriels juxtagloméru- laires du rein, Arch. Biol. (Liege) 43:575.

    Google Scholar 

  • Goormaghtigh, N., 1939, Existence of an endocrine gland in the media of the renal arterioles, Proc. Soc. Exp. Biol. Med. 42:688.

    CAS  Google Scholar 

  • Gould, A.B., Skeggs, L.T. Jr., and Kahn, J.R., 1964, The presence of renin activity in blood vessel walls, J. Exp. Med. 119:389.

    PubMed  CAS  Google Scholar 

  • Granger, P., Dahlheim, H., and Thurau, K., 1972, Enzyme activities of the single juxtaglomerular apparatus in the rat kidney, Kidney Int. 1:78.

    PubMed  CAS  Google Scholar 

  • Grängsjö, G., and Wolgast, M., 1972, The pressure-flow relationship in renal cortical and medullary circulation, Acta Physiol. Scand. 82:228.

    Google Scholar 

  • Granström, E., 1975, Metabolism of 17-phenyl-18, 19, 20-trinorprostaglandin F in the cynomolgus monkey and the human female, Prostaglandins 9:19.

    PubMed  Google Scholar 

  • Grantham, J.J., 1974, Action of antidiuretic hormones in the mammalian kidney, in “MTP International Review of Science, Physiology Series One, Vol. 6, Kidney and Urinary Tract Physiology,” (A.C. Guyton and K. Thurau, eds) pp. 247–272.

    Google Scholar 

  • Greenberg, S., Wilson, W.R., and Howard, L., 1974, Mechanism of the vasosconstrictor action of prostaglandin B, J. Pharmacol. Exp. Ther. 190:59.

    PubMed  CAS  Google Scholar 

  • Grez, M.M., 1974, The influence of antibodies against bradykinin on isotonic saline diuresis in the rat, Pflug. Arch. 350:231.

    CAS  Google Scholar 

  • Grollman, A., and Krishnamusty, V.S.R., 1971, A new pressor agent of renal origin: Its differentiation from renin and angiotensin, Amer. J. Physiol. 221:1499.

    PubMed  CAS  Google Scholar 

  • Gross, F., 1971, Renin stores in the kidney and plasma renin activity, in “Kidney Hormones” (J.W. Fisher, ed.) pp. 93–116, Academic Press, New York.

    Google Scholar 

  • Grünfeld, J.P., Raphael, J.E., Bunkir, L., Kleinknecht, D., and Barger, A.C., 1971, Intrarenal distribution of blood flow, in “Advances in Nephrology,” Vol. 1, (J. Hamburger, J. Crosnier, and M.H. Maxwell, eds.) Yearbook Medical Publishers, Chicago, pp. 125–143.

    Google Scholar 

  • Gryglewski, R., and Vane, J.R., 1970, The inactivation of nonadren-aline and isoprenaline in dogs, Br. J. Pharmacol. 39:573.

    PubMed  CAS  Google Scholar 

  • Guyton, A.C., Langston, J.B., and Navar, B., 1964, Theory for renal autoregulation by feedback at the juxtaglomerular apparatus, Circ. Res. 15 (Suppl. I):187.

    PubMed  CAS  Google Scholar 

  • Hall, R.E., and Buckalew, V.M., 1975, Effect of hypothalamic stimulation on renal blood flow and sodium excretion, Clin. Res. 23:363A.

    Google Scholar 

  • Hamberg, M., 1969, Biosynthesis of prostaglandin in the renal medulla of the rabbit, FEBS Lett. 5:127.

    PubMed  CAS  Google Scholar 

  • Hamberg, M., and Samuelsson, B., 1966, Prostoglandins in human seminal plasma, J. Biol. Chem., 241:257.

    PubMed  CAS  Google Scholar 

  • Hansen, H.S., 1974, Inhibition by indomethacin and aspirin of 15-hydroxy-prostaglandin dehydrogenase in vitro, Prostaglandins 8:95.

    PubMed  CAS  Google Scholar 

  • Hársing, L., Kállay, K., Bartha, J., and Debreczeni, L., 1969, Effect of hyperoncotic albumin and isotonic saline infusion on renal medullary blood flow, Acta Physiol. Acad. Sci. Hung. 36:227.

    PubMed  Google Scholar 

  • Hartroft, P.M., 1963, Juxtaglomerular cells, Girc. Res. 12:525.

    CAS  Google Scholar 

  • Hayduk, K., Krause, D.K., Kaufmann, W., Huenges, R., Schillmoller, U., and Unbehaun, V., 1973, Age dependent changes of plasma renin concentration in humans, Clin. Sci. Mol. Med. 45:273s.

    Google Scholar 

  • Hays, R.M., and Levine, S.D., 1974, Vasopressin, Kidney Int. 6:307.

    PubMed  CAS  Google Scholar 

  • Hedquist, P., 1970, Studies on the effect of prostaglandin E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues, Acta Physiol. Scand. (Suppl.) 345:1.

    Google Scholar 

  • Hedquist, P., Stjärne, L., and Wemmalm, A., 1971, Facilitation of sympathetic neurotransmission in the cat spleen after inhibition of prostaglandin synthesis, Acta Physiol. Scand. 83:430.

    Google Scholar 

  • Hensby, C.N., 1974, Reduction of prostaglandin E2 to prostaglandin F by an enzyme in sheep blood, Biochim. Biophys. Acta 348:145.

    PubMed  CAS  Google Scholar 

  • Herbaczynska-Cedro, K., and Vane, J.R., 1973, Contribution of intrarenal generation of prostaglandin in autoregulation of renal blood flow in the dog, Circ. Res. 33:428.

    PubMed  CAS  Google Scholar 

  • Herbaczynska-Cedro, K., and Vane, J.R., 1974, Prostaglandins as mediators or reactive hyperemia in kidney, Nature 247:492.

    PubMed  CAS  Google Scholar 

  • Herrick, J.F., Corcoran, A.C., and Essex, H.E., 1942, The effects of renin and of angiotensin on the renal blood flow and blood pressure of the dog, Am. J. Physiol. 135:88.

    Google Scholar 

  • Hickler, R.B., Lauler, D.P., Saravis, C.A., Vugnucci, A.I., Steiner, G., and Thorn, G.W., 1964, Vasodepressor lipid from the renal medulla, Can. Med. Assoc. J. 90:280.

    PubMed  CAS  Google Scholar 

  • Hierholzer, K., and Lange, S., 1974, The effects of adrenal steroids on renal function, in “MTP International Review of Science, Physiology Series One, Vol. 6, Kidney and Urinary Tract Physiology” (A.C. Guyton and K. Thurau, eds.) pp. 273–333, Butterworths, London.

    Google Scholar 

  • Hill, J.R., and Pickering, G.W., 1940, Hypertension produced in the rabbit by prolonged renin infusion, Clin. Sci. 4:207.

    Google Scholar 

  • Hinman, J.W., 1967, The prostaglandins, Bioscience 17:779.

    CAS  Google Scholar 

  • Hiwada, K., Kokubu, T., Yamamura, Y., 1969, Inhibitory effect of rabbit bile on renin angiotensin reaction system, Jap. Circ. J. 33:1231.

    PubMed  CAS  Google Scholar 

  • Hodge, R.L., Ng, K.K.F., and Vane, J.R., 1967, Disappearance of angiotensin from the circulation of the dog, Nature 215:138.

    PubMed  CAS  Google Scholar 

  • Hollenberg, N.K., Birtch, A., Rashid, A., Mangel, R., Briggs, W., Epstein, M., Murray, J.E., and Merrill, J.P., 1970, “Relationships between intrarenal perfusion and function: Serial hemodynamic studies in the transplanted human kidney,” Medicine 51:95.

    Google Scholar 

  • Hollenberg, N.K., 1973, Renal disease, in “The Microcirculation in Clinical Medicine” (R. Wells, ed.) pp. 61–80, Academic Press, New York.

    Google Scholar 

  • Hollenberg, N.K., and Adams, D.F., 1974, Vascular factors in the pathogenesis of acute renal failure in man, in “Proceedings: Renal Failure Conference, 1973” (E.A. Friedman and H.E. Eliahou, eds.) DHEW Publ. No. (NIH) 74–603, pp. 209–229.

    Google Scholar 

  • Hollenberg, N.K., Adams, D.F., Solomon, H., Clenitz, W.R., Burger, B.M., Abrams, H.L., and Merrill, J.P., 1975 “Renal vascular tone in essential and secondary hypertension: Hemodynamic and angiographic responses to vasodilators, Medicine 54:29.

    PubMed  CAS  Google Scholar 

  • Horton, E.W., and Main, I.H.M., 1963, A comparison of the biological activities of four prostaglandins, Brit. J. Pharmacol. 21:182.

    PubMed  CAS  Google Scholar 

  • Innes, I.R., and Nickerson, M., 1970, Drugs acting on postganglionic adrenergic nerve ending and structures innervated by them (sympathomimetic drugs), in “The Pharmacological Basis of Therapeutics” (L.S. Goodman and A. Gilman, eds.) pp. 478–523, MacMillan Co., New York.

    Google Scholar 

  • Itskovitz, H.D., and McGiff, J.C., 1974, Hormonal regulation of the renal circulation, Circ. Res. 34 (Suppl. I):65.

    CAS  Google Scholar 

  • Itskovitz, H.D., Stempler, J., Pacholczyk, D., and McGiff, J.C., 1973, Renal prostaglandins: Determinants of intrarenal distribution of blood flow in the dog, Clin. Sci. Mol. Med. 45 (Suppl. I):321.

    Google Scholar 

  • Itskovitz, H.D., Terragno, N.A., and McGiff, J.C., 1974, Effect of a renal prostaglandin on distribution of blood flow in the isolated canine kidney, Circ. Res. 34:770.

    PubMed  CAS  Google Scholar 

  • Jaenike, J.R., 1972, The renal functional defect of postobstructive nephropathy: The effects of bilateral ureteral obstruction in the rat, J. Clin. Invest. 51:2999.

    PubMed  CAS  Google Scholar 

  • Jaffe, B.M., Behrman, H.R., and Parker, C.W., 1973, Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma, J. Clin. Invest. 52:398.

    PubMed  CAS  Google Scholar 

  • Janszen, F.H.A., and Nugteren, D.H., 1971, Histochemical localization of prostaglandin synthetase, Histochemie 27:159.

    PubMed  CAS  Google Scholar 

  • Johnson, J.A., Davis, J.O., and Witty, R.T., 1971, Effects of catecholamines and renal nerve stimulation on renin release in the nonfiltering kidney, Circ. Res. 29:646.

    PubMed  CAS  Google Scholar 

  • Johnson, J.A., Davis, J.O., Brown, P.R., Wheeler, P.D., and Witty, R.T., 1972, Effects of estradiol on sodium and potassium balances in adrenalectomized dogs, Am. J. Physiol. 223:194.

    PubMed  CAS  Google Scholar 

  • Johnston, C.I., Matthews, P.G., Davis, J.M., and Morgan, T., 1975, Renin measurement in blood collected from the efferent arteriole of the kidney of the rat, Pflug. Arch. 356:277.

    CAS  Google Scholar 

  • Johnston, H.H., Herzog, J.P., and Lauler, D.P., 1967, Effect of prostaglandin E1 on renal hemodynamics, sodium and water excretion, Am. J. Physiol. 213:939.

    PubMed  CAS  Google Scholar 

  • Jones, R.L., 1972, Properties of a new prostaglandin, Brit. J. Pharmacol. 45:144.

    Google Scholar 

  • Jones, R.L., and Cammock, S., 1973, Purification, properties, and biological significance of prostaglandin A isomerase, Adv. Biosci. 9:61.

    Google Scholar 

  • Kaley, G., and Weiner, R., 1971(a), Effect of prostaglandin E1 on leucocyte migration, Nature (New Biol.) 234:114.

    CAS  Google Scholar 

  • Kaley, G., and Weiner, R., 1971, Prostaglandin E1: A potential mediator of the inflammatory response, Ann. N.Y. Acad. Sci. 180:338.

    PubMed  CAS  Google Scholar 

  • Källskog, Ö., Ulfendahl, H.R., and Wolgast, M., 1972, Single glomerular blood flow as measured with carbonized 141-Ce labeled microspheres, Acta Physiol. Scand. 85:408.

    PubMed  Google Scholar 

  • Kaplan, A.P., Austen, K.F., 1971, A prealbumin activator of prekallikrein. II. Derivation of activators of prekallikrein from active Hageman factor by digestion with plasmin, J. Exp. Med. 133:696.

    PubMed  CAS  Google Scholar 

  • Katz, M.A., and Shear, L., 1975a, Effects of renal nerves on renal hemodynamics: I. Direct stimulation and carotid occlusion Nephron 14:246.

    PubMed  CAS  Google Scholar 

  • Katz, M.A., and Shear, L., 1975b, Effects of renal nerves on renal hemodynamics: II. Renal denervation models, Nephron 14:390.

    PubMed  CAS  Google Scholar 

  • Kellermeyer, R.W., and Graham, R.C., 1968, Kinins — possible physiologic and pathologic roles in man, New Engl. J. Med. 279:754.

    PubMed  CAS  Google Scholar 

  • Kemp, E., and Rubin, I., 1964, Molecular weight of renin determined by Sephedex gel filtration, Acta. Chem. Scand. 18:2403.

    CAS  Google Scholar 

  • Keyl, M.J., Bell, R.D., and Parry, W.L., 1972, Summary of renal lymphatic studies, Trans. Am. Assoc. Genito-Urinary Surg. 64:140.

    CAS  Google Scholar 

  • Kiil, F., 1971, Blood flow and oxygen utilization by the kidney, in “Kidney Hormones” (J.W. Fisher, ed.), pp. 1–30, Academic Press, New York.

    Google Scholar 

  • Kiil, F., Kjekshus, J., and Löyning, E., 1969, Renal autoregulation during infusion of noradrenaline, angiotensin, and acetylcholine, Acta Physiol. Scand. 76:10.

    PubMed  CAS  Google Scholar 

  • Kilo, C., Vogler, N., and Williamson, J.R., 1972, Muscle Capillary basement membrane changes related to aging and to diabetes mellitus, Diabetes 21:881.

    PubMed  CAS  Google Scholar 

  • Kincaid-Smith, P., Friedman, A., and Hobbs, J.B., 1974, Morphological effects of angiotensin in arteries, in “Handbook of Experimental Pharmacology, Vol. 37, Angiotensin” (I.H. Page and F.M. Bumpus, eds.) pp. 490–499, Springer-Verlag, New York.

    Google Scholar 

  • Kirschenbaum, M.A., White, N., Stein, J.H., and Ferris, T.F., 1974, Redistribution of renal cortical blood flow during inhibition of prostaglandin synthesis, Am. J. Physiol. 227:801.

    PubMed  CAS  Google Scholar 

  • Kleinman, L.I., and Reuter, V.H., 1974, Renal response of the newborn dog to a saline load: The role of intrarenal blood flow distribution, J. Physiol. 239:225.

    PubMed  CAS  Google Scholar 

  • Kotchen, T.A., Hedrick, J.L., Miller, M.C., and Talwalker, R.T., 1974, Effect of prostaglandins on the velocity of the reaction between human renin and homologous renin substrate, J. Clin. Endocrinol. Metab. 39:530.

    PubMed  CAS  Google Scholar 

  • Kramer, K., Thurau, K., and Deetjen, P., 1960, Haemodynamik des Neirenmarks: I. Capillarie Passagezet, Durchblutung, Gewebshaematokrit, und O2-Verbrauch des Nierenmarks in situ, Arch. Ges. Physiol. 270:251.

    CAS  Google Scholar 

  • Kraut, H., Frey, E.K., and Werle, E., 1930, Der Nachweis Eines Kreislaufhormons in der Pankreasdrüse, Hoppe-Seyler’s Z. Physiol. Chem. 189:97.

    CAS  Google Scholar 

  • Kreiger, G., 1970, Thesis, University of Heidelberg, quoted in Gross (1971), p. 112.

    Google Scholar 

  • Kriz, W., 1967, Der architektonische und funktionelle Aufbau der Rattenniere, Z. Zellforsch, Mikrosk. Anat. 82:495.

    CAS  Google Scholar 

  • Keuhl, F.A., Oien, H.G., and Ham, E.A., 1974, Prostaglandins and prostaglandin synthetase inhibitors: Actions on cell function, in “Prostaglandin Synthetase Inhibitors,” (H.J. Robinson and J.R. Vane, eds.) pp. 53–65, Raven Press, New York.

    Google Scholar 

  • Kurz, K.D., Hasbargen, J.A., and Zehr, J.E., 1975, Effects of increased left atrial transmural pressure on renin secretion, Ped. Proc. 34:367.

    Google Scholar 

  • Ladefoged, L., and Munck, O., 1971, Distribution of blood flow in the kidney, in “Kidney Hormones” (J.W. Fisher, ed.) pp. 31–58, Academic Press, New York.

    Google Scholar 

  • Lameire, N., Schaper, W., and Ringoir, S., 1972, Circulation intrarénale dans l’intoxication mercurielle du rat étudié par microsphères marquées, J. Urol. Nephrol. 78:771.

    CAS  Google Scholar 

  • Laragh, J.H., Cannon, P.J., Bentzel, C.J., Sicinski, A.M., and Meltzer, J.I., 1963, Angiotensin II, norepinephrine, and renal transport of electrolytes and water in normal man and in cirrhosis with ascites, J. Clin. Invest. 42:1179.

    PubMed  CAS  Google Scholar 

  • Laragh, J.H., and Sealey, J.E., 1973, The renin-angiotensin-aldosterone hormonal system and regulation of sodium, postassium, and blood pressure homeostasis, in “Handbook of Physiology, Section 8: Renal Physiology,” (J. Orloff and R.W. Berliner, eds.) pp. 831–908, Williams and Wilkins, Baltimore.

    Google Scholar 

  • Larsson, C., and Änggård, E., 1973, Regional differences in the formation and metabolism of prostaglandins in the rabbit kidney, Eur. J. Pharmacol. 21:30.

    PubMed  CAS  Google Scholar 

  • Larsson, C., Weber, P., and Änggård, E., 1974, Arachidonic acid increases and indomethacin decreases plasma renin activity in the rabbit, Eur. J. Pharmacol. 28:391.

    PubMed  CAS  Google Scholar 

  • Lassiter, W.E., 1975, Kidney, Ann. Rev. Physiol. 37:371.

    CAS  Google Scholar 

  • Ledingham, J.G., and Leary, W.P., 1974, Catabolism of Angiotensin II, in “Handbook of Experimental Pharmacology, Vol. 37, Angiotensin,” (I.H. Page and F.M. Bumpus, eds.) pp. 111–125, Springer-Verlag, New York.

    Google Scholar 

  • Lee, J.B., 1968, Cardiovascular implications of the renal prostaglandins in “Prostaglandin Symposium of the Worcester Foundation,” (P.W. Ramwell and J.E. Shaw, eds.) pp. 131–146, Interscience, New York.

    Google Scholar 

  • Lee, J.B., 1972, Natriuretic “hormone” and the renal prostaglandins, Prostaglandins 1:55.

    PubMed  CAS  Google Scholar 

  • Lee, J.B., Mazzeo, M.A., and Takman, B.H., 1964, The acidic lipid characteristics of sustained renomedullary depressor activity, Clin. Res. 12:254.

    Google Scholar 

  • Lee, J.B., Crowshaw, K., Takman, B.H., Attrep, K.A., and Gougoutas, J.Z., 1967, The identification of prostaglandins E2, F, and A2 from rabbit kindney medulla, Biochem. J. 105: 1251.

    PubMed  CAS  Google Scholar 

  • Lee, J.B., Crowshaw, K., Takman, B.H., Attrep, K.A., and Gougoutas, J.Z., 1967, Identification of prostaglandins E2, F, and A2 from rabbit renal medulla, Biochem. J. 105:1251.

    PubMed  CAS  Google Scholar 

  • Lee, S.J., Johnson, J.G., Smith, C.J., and Hatch, F.E., 1972, Renal effects of prostaglandin A1 in patients with essential hypertension, Kidney Int. 1:254.

    PubMed  CAS  Google Scholar 

  • Leon, A.S., and Bloor, C.M., 1974, Effects of chronic exercise on the kidneys at different ages, Life Sci. 15:29.

    PubMed  CAS  Google Scholar 

  • Levitt, M.F., and Bader, M.E., 1951, Effect of cortisone and ACTH on fluid and electrolyte distribution in man, Am. J. Med. 11:715.

    PubMed  CAS  Google Scholar 

  • Lilienfield, L.S., Maganzini, H.C., and Bauer, M.H., 1961, Blood flow in the renal medulla, Circ. Res. 9:614.

    PubMed  CAS  Google Scholar 

  • Ljungqvist, A., 1964, Structure of the arteriole-glomerular units in different zones of the kidney, Nephron 1:329.

    PubMed  CAS  Google Scholar 

  • Ljungqvist, A., Wagermark, J., 1970, The adrenergic innervation of intrarenal glomerular and extra-glomerular circulatory routes, Nephron 7:218.

    PubMed  CAS  Google Scholar 

  • Limas, C.J., 1974, Stimulation by angiotensin of myocardial prostaglandin synthesis, Biochim. Biophys. Acta 337:417.

    PubMed  CAS  Google Scholar 

  • Lonigro, A.J., Itskovitz, H.D., Crowshaw, K., and McGiff, J.C., 1973, Dependency of renal blood flow on prostaglandin synthesis in the dog, Circ. Res. 32:712.

    PubMed  CAS  Google Scholar 

  • Lundgren, O., and Jodal, M., 1975, Regional blood flow, Ann. Rev. Physiol. 37:395.

    CAS  Google Scholar 

  • Mancia, G., Romero, J.C., and Shepherd, J.T., 1975, Control of renin release by cardiopulmonary receptors, Circulation 50 (Suppl. III):63.

    Google Scholar 

  • Mangel, R., Hollenberg, N.K., and Merrill, J.P., 1970, Radioisotope washout for measurement of renal blood flow, Fed. Proc. 29:397A.

    Google Scholar 

  • Mark, A.L., Eckstein, J.W., Abboud, F.M., and Wendung, M.G., 1969, Renal vascular responses to isoproterenol, Am. J. Physiol. 217:764.

    PubMed  CAS  Google Scholar 

  • McCluskey, R.T., 1974, Immunologic mechanisms in renal disease, in R. H. Heptinstall “Pathology of the Kidney,” pp. 273–317, Little, Brown and Co., Boston.

    Google Scholar 

  • McGiff, J.C., Crowshaw, K., Terragno, N.A., and Lonigro, A.J., 1970, Renal prostaglandins: Possible regulators of the renal actions of pressor hormones, Nature 227:1255.

    PubMed  CAS  Google Scholar 

  • McGiff, J.C., Crowshaw, K., Terragno, N.A., Malik, K.U., and Lonigro, A.J., 1972, Differential effect of noradrenalin and renal nerve stimulation on vascular resistance in the dog kidney and the release of prostaglandin E-like substance, Clin. Sci. 42:223.

    PubMed  CAS  Google Scholar 

  • McGiff, J.C., and Fasy, T.M., 1965, The relationship of the renal vascular activity of angiotensin II to the autonomic nervous system, J. Clin. Invest. 44:1911.

    PubMed  CAS  Google Scholar 

  • McGiff, J.C., and Itskovitz, H.D., 1973, Prostaglandins and the kidney, Circ. Res. 33:479.

    PubMed  CAS  Google Scholar 

  • McGiff, J.C., Terragno, N.A., Malik, K.D., and Lonigro, A.J., 1972, Release of a prostaglandin E-like substance from canine kidney by bradykinin, Circ. Res. 31:36.

    PubMed  CAS  Google Scholar 

  • McGiff, J.C., Terragno, D.A., Terragno, N.A., and Mulik, K.U., 1975, Vascular reactivity and prostaglandins, (remarks at Symposium on “The role of prostaglandins in vascular homeostasis,” 59th Annual Meeting Federation of American Societies for Experimental Biology, Atlantic City, N.J., April 17, 1975).

    Google Scholar 

  • McNay, J.L., and Kishimoto, T., 1969, Association between auto-regulation and pressure dependency of renal vascular responsiveness in dogs, Circ. Res. 24:599.

    PubMed  CAS  Google Scholar 

  • McNay, J.L., and Abe, Y., 1970, Pressure-dependent heterogeneity of renal cortical blood flow in dogs, Circ. Res. 25:571.

    Google Scholar 

  • Menzie, J.W., and Michelakis, A.M., 1972, Renin release from the submaxillary gland by alpha-adrenergic agonists, Fed. Proc. 31:511.

    Google Scholar 

  • Merrill, J.E., Peach, M.J., and Gilmore, J.P., 1973, Angiotensin I conversion in the kidney and its modulation by sodium balance, Am. J. Physiol. 224:1104.

    PubMed  CAS  Google Scholar 

  • Michelakis, A.M., Caudle, J., and Liddle, G.W., 1969, In vitro stimulation of renin production by epinephrine, norepinephrine, and cyclic AMP, Proc. Soc. Exp. Biol. Med. 130:748.

    PubMed  CAS  Google Scholar 

  • Miller, W.L., Weeks, J.R., Lauderdale, J.W., and Kirton, K.T., 1975, Biological activites of 17-phenyl-18, 19, 20-trinorprostaglan-dins, Prostaglandins 9:9.

    PubMed  CAS  Google Scholar 

  • Milton, A.S., and Wendlandt, S., 1971, Effects on body temperature of prostaglandins of the A, E, and F series on injection into the third ventricle of unanesthetized cats and rabbits, J. Physiol. (London) 218:325.

    CAS  Google Scholar 

  • Misiewicz, J.J., Waller, S.L., and Kiley, N., 1969, Effects of prostaglandin E1 on intestinal transit in man, Lancet 1:648.

    PubMed  CAS  Google Scholar 

  • Moffat, D.B., and Fourman, J., 1963, The vascular pattern of the rat kidney, J. Anat. 97:543.

    PubMed  CAS  Google Scholar 

  • Moritz, A.R., and Oldt, M.R., 1937, Arteriolar sclerosis in hypertensive and non-hypertensive individuals, Am. J. Pathol. 13:679.

    PubMed  CAS  Google Scholar 

  • Moriuchi, K., Tanaka, H., Yamamoto, K., and Ueda, J., 1971, Distribution of renin in the dog kidney, Life Sci. 10:727.

    Google Scholar 

  • Mowat, P., Lupu, A.N., and Maxwell, M.H., 1972, Limitations of 133Xe washout technique in estimation of renal blood flow, Am. J. Physiol. 223:682.

    PubMed  CAS  Google Scholar 

  • Muirhead, E.E., Leach, B.E., Byers, L.W., Brooks, B., Daniels, E.G., and Hinman, J.W., 1971, Antihypertensive neutral renomedullary lipids (ANRL), in “Kidney Hormones” (J.W. Fisher, ed.) pp. 405–506, Academic Press, New York.

    Google Scholar 

  • Muirhead, E.E., Germain, G., Leach, B.E., Pitcock, V.A., Stephenson, P., Brooks, B., Brosius, W.L., Daniels, E.G., and Hinman, J.W., 1972, Production of renomedullary prostaglandins by renomedullary interstitial cells grown in tissue culture, Circ. Res. 31 (Suppl. II):161.

    PubMed  Google Scholar 

  • Mulrow, P.J., Ganong, W.F., Cera, G., and Kuljian, A., 1962, The nature of the aldosterone-stimulating factor in dog kidneys, J. Clin. Invest. 41:505.

    PubMed  CAS  Google Scholar 

  • Murakami, K., and Inagami, T., 1975, Isolation of pure and stable renin from hog kidney, Biochem. Biophys. Res. Comm. 62:757.

    PubMed  CAS  Google Scholar 

  • Myers, B.D., Deen, W.M., Robertson, C.R., and Brenner, B.M., 1975, Dynamics of glomerular ultrafiltration in the rat, VIII. Effects of hematocrit, Circ. Res. 36:425.

    PubMed  CAS  Google Scholar 

  • Nakamura, M., Ezaki, I., Sumiyashi, A., Kai, M., Kanaide, H., Naito, D., and Kato, K., 1975, Renal subcellular fractions producing angionecrosis and increased vascular permeability, Br. J. Exp. Pathol. 56:62.

    PubMed  CAS  Google Scholar 

  • Nakano, J., 1973, General pharmacology of prostaglandins, in “The Prostaglandins,” (M.F. Cuthbert, ed.) pp. 23–124, Lippincott, Philadelphia.

    Google Scholar 

  • Nakano, J., and Cole, B., 1969, Effects of prostaglandin E1 and F on systemic, pulmonary and splanchnic circulations in dogs, Am. J. Physiol. 217:222.

    PubMed  CAS  Google Scholar 

  • Nakano, J., and McCurdy, J.R., 1967, Cardiovascular effects of prostaglandin E1, J. Pharmacol. Exp. Ther. 156:538.

    PubMed  CAS  Google Scholar 

  • Nakano, J., and McCurdy, J.R., 1968, Hemodynamic effects of prostaglandins E1, A1, and F in dogs, Proc. Soc. Exp. Biol. Med. 128:39.

    PubMed  CAS  Google Scholar 

  • Navar, L.G., and Langford, H.G., 1974, Effects of angiotensin on the renal circulation, in “Handbook of Experimental Pharmacology, Vol. 37, Angiotensin” (I.H. Page and F.M. Bumpus, eds.) pp. 455–474, Springer-Verlag, New York.

    Google Scholar 

  • Nissen, H.M., and Andersen, H., 1968, On the localization of a prostaglandin dehydrogenase activity in the kidney, Histochemie 14:189.

    PubMed  CAS  Google Scholar 

  • Ng, K.K.F., and Vane, J.R., 1967, Conversion of angiotensin I to angiotensin II, Nature 216:762.

    PubMed  CAS  Google Scholar 

  • Ng, K.K.F., and Vane, J.R., 1968, Fate of angiotensin I in the circulation, Nature 218:144.

    PubMed  CAS  Google Scholar 

  • Nishiyama, A., Rikimaru, A., Fukushi, Y., and Suzuki, T., 1972, Effect of “substance R” on the cat blood pressure, Tohoku J. Exp. Med. 106:207.

    PubMed  CAS  Google Scholar 

  • Nustad, K., 1970a, The relationship between kidney and urinary kininogenase, Br. J. Pharmacol. 39:73.

    PubMed  CAS  Google Scholar 

  • Nustad, K., 1970b, Localization of kininogenase in the rat kidney, Br. J. Pharmacol. 39:87.

    PubMed  CAS  Google Scholar 

  • O’Dorisio, T.M., Stein, J.H., Osgood, R.W., and Ferris, T.F., 1973, Absence of aglomerular blood flow during renal vasodilatation and hemorrhage in the dog, Proc. Soc. Exp. Biol. Med. 143:612.

    PubMed  Google Scholar 

  • Oliver, W.J., and Gross, F., 1966, Unique specificity of mouse angiotensin to homologous renin, Proc. Soc. Exp. Biol. Med. 122:923.

    PubMed  CAS  Google Scholar 

  • Oparil, S., and Haber, E., 1974, The renin-angiotensin system, New Engl. J. Med. 291:389.

    PubMed  CAS  Google Scholar 

  • Owen T., Ehrhart, I., Weider, J., Haddy, F., and Scott, J., 1974, Effects of indomethacin on blood flow, reactive hyperemia and autoregulation in the dog kidney, Fed. Proc. 33:348.

    Google Scholar 

  • Page, I.H., and Helmer, O.M., 1940, A crystalline pressor substance (angiotonin) resulting from the reaction between renin and renin-activator, J. Exp. Med. 71:29.

    PubMed  CAS  Google Scholar 

  • Page, I.H., McSwain, B., Knapp, G.M., and Andrus, W.D., 1941, The origin of renin-activator, Am. J. Physiol. 135:214.

    CAS  Google Scholar 

  • Pals, D.T., Masucci, F.D., Sipos, F., and Denning, G.S. Jr., 1971, A specific competitive antagonist of the vascular action of angiotensin II, Circ. Res. 29:664.

    PubMed  CAS  Google Scholar 

  • Pappenheimer, J.R., and Kinter, W.B., 1956, Hematocrit ratio of blood within mammalian kidney and its significance for renal hemodynamics, Am. J. Physiol. 185:377.

    PubMed  CAS  Google Scholar 

  • Peach, M.J., and Chiu, A.T., 1974, Stimulation and inhibition of aldosterone biosynthesis in vitro by angiotensin II and analogs, Circ. Res. 34 (Suppl. I):7.

    CAS  Google Scholar 

  • Peart, W.S., 1956, The isolation of a hypertensin, Biochem. J. 62:520.

    PubMed  CAS  Google Scholar 

  • Peart, W.S., 1971, Renin-angiotensin system in hypertensive disease, in “Kidney Hormones” (J.W. Fisher, ed.), pp. 217–242, Academic Press, New York.

    Google Scholar 

  • Peart, W.S., 1975, Renin-angiotensin system, New Engl. J. Med. 292:302.

    PubMed  CAS  Google Scholar 

  • Piper, P.J., and Vane, J.R., 1969, Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs, Nature 223:29.

    PubMed  CAS  Google Scholar 

  • Plakke, R.K., Pfeiffer, E.W., 1964, Blood vessels of the mammalian renal medulla, Science 146:1683.

    PubMed  CAS  Google Scholar 

  • Poulsen, K., 1968, Measurement of renin in human plasma, Scand. J. Clin. Lab. Invest. 21:49.

    PubMed  CAS  Google Scholar 

  • Poulsen, K., 1971, No evidence of active renin-inhibition in plasma. The kinetics of the reaction between renin and substrate in non-pretreated plasma, Scand. J. Clin. Lab. Invest. 27:37.

    PubMed  CAS  Google Scholar 

  • Poulsen, K., and Poulsen, L.L., 1971, Simultaneous determination of plasma converting enzyme and angiotensinase activity by radioimmunoassay, Clin. Sci. 40:443.

    PubMed  CAS  Google Scholar 

  • Prado, J.L., Limãos, E.A., Roblero, J., Nuñez, S.T., and Prado, E.S., 1975, In vivo conversion of kinins by exsanguinated rat preparations, Fed. Proc. 34:819.

    Google Scholar 

  • Rao, U.V.G., and Wagner, H.N. Jr., 1972, Normal weights of human organs, Radiology 102:337.

    PubMed  CAS  Google Scholar 

  • Rasmussen, S.N., 1972, Influence of plasma hypertonicity on blood viscosity studied in vitro and in an isolated vascular bed, Acta Physiol. Scand 84:472.

    PubMed  CAS  Google Scholar 

  • Rasmussen, S.N., 1973, Intrarenal red cell and plasma volumes in the nondiuretic rat, Pflug. Arch. 342:61.

    CAS  Google Scholar 

  • Rector, J.B., Stein, J.H., Bay, W.H., Osgood, R.W., and Ferris, T.F., 1972, Effect of hemorrhage and vasopressor agents on distribution of renal blood flow, Am. J. Physiol. 222:1125.

    PubMed  CAS  Google Scholar 

  • Reinhardt, H.W., Kaczmarczyk, G., Fahrenhorst, K., Bledinger, I., Gatzka, M., Kuhl, U., and Riedel, J., 1975, Post-prandial changes of renal blood flow, Pflug. Arch. 354:287.

    CAS  Google Scholar 

  • Robinson, D.S., Nies, A., Davis, J.N., Bunney, W.E., Davis, J.M., Colburn, R.W., Bourne, H.R., Shaw, D.M., and Coppen, A.J., 1972, Ageing, monoamines and monoamine-oxidase levels, Lancet 1:290.

    PubMed  CAS  Google Scholar 

  • Robinson, H.J., and Vane, J.R., (eds.), 1974, “Prostaglandin Synthetase Inhibitors,” Raven Press, New York.

    Google Scholar 

  • Rocha e Silva, M., 1970, “Kinin Hormones,” p. 164, Charles C. Thomas, Springfield.

    Google Scholar 

  • Rome, L.H., and Lands, W.E.M., 1975, Inhibition of prostaglandin synthesis, Fed. Proc. 34:790.

    Google Scholar 

  • Rouffignac, C. de, Bonvalet, J.P., and Menard, J., 1974, Renin content in superficial and deep glomeruli of normal and salt-loaded rat, Am. J. Physiol. 226:150.

    PubMed  Google Scholar 

  • Ruiz-Maza, F., Tiller, D.J., and Walker, W.G., 1974, Measurement of angiotensin II in an ultrafiltrate of plasma, Johns Hopkins Med. J. 135:211.

    PubMed  CAS  Google Scholar 

  • Ryan, J.W., 1974, The fate of angiotensin II, in “Handbook of Experimental Pharmacology, Vol. 37, Angiotensin” (I.H. Page and F.M. Bumpus, eds.) pp. 81–110, Springer-Verlag, New York.

    Google Scholar 

  • Ryan, J.W., Smith, U., and Niemeyer, R.S., 1972, Angiotensin I: Metabolism by plasma membrane of lung, Science 176:64.

    PubMed  CAS  Google Scholar 

  • Sample, S.J.G., and de Wardener, H.E., 1959, Effect of increased renal venous pressure on circulatory autoregulation of isolated dog kidneys, Circ. Res. 7:643.

    Google Scholar 

  • Samuelsson, B., 1970, in “Pharmacology of the Prostaglandins,” Proc. 4th Inter. Congr. Pharmacol., p. 12, Schwabe and Co., Basel.

    Google Scholar 

  • Samuelsson, B., and Hamberg, M., 1974, Role of endoperoxides in the biosynthesis and action of prostaglandin, in “Prostaglandin Synthetase Inhibitors” (H.J. Robinson and J.R. Vane, eds.) pp. 107–119, Raven Press, New York.

    Google Scholar 

  • Samuelsson, B., and Wennmalm, A., 1971, Increased nerve stimulation induced release of noradrenalin from the rabbit heart after inhibition of prostaglandin synthesis, Acta. Physiol. Scand. 83:163.

    PubMed  CAS  Google Scholar 

  • Sassard, J., Sann, L., Vincent, M., Francois, R., and Cier, J.F., 1975, Plasma renin activity in normal subjects from infancy to puberty, J. Clin. Endocrinol. Metab. 40:524.

    PubMed  CAS  Google Scholar 

  • Satoh, S., and Zimmerman, B.G., 1974, Participation of intrarenal prostaglandin in renal ischemia, Fed. Proc. 33:576.

    Google Scholar 

  • Satoh, S., Kraft, E., and Zimmerman, B., 1975, Effect of l-Sar-8-Ala angiotensin II (P-113) on blood pressure, renal blood flow and plasma renin in conscious dog, Fed. Proc. 34:770.

    Google Scholar 

  • Schaffenburg, C.A., Haas, E., and Goldblatt, H., 1960, Concentration of renin in kidneys and angiotensinogen in serum of various species, Am. J. Physiol. 199:788.

    PubMed  CAS  Google Scholar 

  • Schmid, H.E., 1972, Renal autoregulation and renin release during changes in renal perfusion pressure, Am. J. Physiol. 222:1132.

    PubMed  CAS  Google Scholar 

  • Schmid-Schönbein, H., Wells, R.E., Goldstone, J., 1973, Effect of ultrafiltration and plasma osmolarity upon the flow properties of blood: A possible mechanism for control of blood flow in the renal medullary vasa recta, Pflug. Arch. 338:93.

    Google Scholar 

  • Schramm, L.P., and Carlson, D.E., 1975, Inhibition of renal vasoconstriction by elevated ureteral pressure, Am. J. Physiol. 228:1126.

    PubMed  CAS  Google Scholar 

  • Schramm, L.P., Anderson, D.E., and Randall, D.C., 1975, Renal blood flow changes during aversive conditioning in the dog. Experientia 31:71.

    PubMed  CAS  Google Scholar 

  • Schrier, R.W., 1974, Effects of adrenergic nerous system and catecholamines on systemic and renal hemodynamics, sodium and water excretion, and renin secretion, Kidney Int. 6:291.

    PubMed  CAS  Google Scholar 

  • Schrier, R.W., and Berl, T., 1973, Mechanism of effect of alpha adrenergic stimulation with norepinephrine on renal water excretion, J. Clin. Invest. 52:502.

    PubMed  CAS  Google Scholar 

  • Scicli, A.G., Carretero, O.A., Hampton, A., and Oza, N.B., 1975, Kallikrein localization in the nephron by the stop-flow technique, Fed. Proc. 34:378.

    Google Scholar 

  • Sealey, J.E., Gerten, J.N., Ledingham, J.G.G., and Laragh, J.H., 1967, Inhibition of renin by heparin, J. Clin. Endocrin. 27:699.

    CAS  Google Scholar 

  • Seikurt, E.E., 1974, Concise review: Current status of renal circulation and related nephron function in hemorrhage and experimental hemorrhagic shock. II. Neurohumoral and tubular mechanisms, Circ. Shock 1:89.

    Google Scholar 

  • Selye, H., 1968, “Anaphylactoid Edema,” p. 21, Warren H. Green, Inc., St. Louis.

    Google Scholar 

  • Sen, S., Smeby, R.R., and Bumpus, F.M., 1972, Renin in rats with spontaneous hypertension, Circ. Res. 31:876.

    PubMed  CAS  Google Scholar 

  • Shade, R.E., Davis, J.O., Johnson, J.A., Witty, R.T., 1972, Effects of renal arterial infusion of sodium and potassium on renin secretion in the dog, Circ. Res. 31:719.

    PubMed  CAS  Google Scholar 

  • Shanser, J.D., Korobkin, M., Scidlitz, L., Carlson, E.L., and Shames, D.M., 1974, Hazards in interpretation of xenon washout studies of the canine kidney, Radiology 111:461.

    PubMed  CAS  Google Scholar 

  • Shimamura, T., and Morrison, A.B., 1973, Vascular permeability of the renal medullary vessels in the mouse and rat, Am. J. Pathol. 71:155.

    PubMed  CAS  Google Scholar 

  • Shipley, R.E., and Helmer, O.M., 1948, Observation on “the sustained pressor principle” in different animal species, Am. J. Physiol. 153:341.

    PubMed  CAS  Google Scholar 

  • Silverman, A.J., and Barajas, L., 1974, Effect of reserpine on the juxtaglomerular granular cells and renal nerves, Lab. Invest. 30:723.

    PubMed  CAS  Google Scholar 

  • Siperstein, M.D., Unger, R.H., and Madison, L.L., 1968, Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients, J. Clin. Invest. 47:1973.

    PubMed  CAS  Google Scholar 

  • Skeggs, L.T., Dorer, F.E., Kahn, J.E., Lentz, K.E., and Levine, M., 1974, The biological production of angiotensin, in “Handbook of Experimental Pharmacology, Vol. 37, Angiotensin” (I.H. Page and F.M. Bumpus, eds.) pp. 1–16, Springer-Verlag, New York.

    Google Scholar 

  • Skeggs, L.T., Kahn, J.R., Lentz, K.E., and Shumway, N.P., 1957, The preparation, purification, and amino acid sequence of a polypeptide renin substrate, J. Exp. Med. 106:439.

    PubMed  CAS  Google Scholar 

  • Skeggs, L.T., Kahn, J.R., and Shumway, N.P., 1956, The preparation and function of the hypertensin-converting enzyme, J. Exp. Med. 103:295.

    PubMed  CAS  Google Scholar 

  • Skeggs, L.T., Lentz, K.E., and Hochstrasser, H., and Kahn, J.R., 1963, The purification and partial characterization of several forms of hog renin substrate, J. Exp. Med. 118:73.

    PubMed  CAS  Google Scholar 

  • Skeggs, L.T., Lentz, K.E., and Hochstrasser, H., and Kahn, J.R., 1964, The chemistry of renin substrate, Canad. Med. Assoc. J. 90:185.

    PubMed  CAS  Google Scholar 

  • Skeggs, L.T., Lentz, K.E., Kahn, J.R., Shumway, N.P., and Woods, K.R., 1956, The amino acid sequence of hypertensin II, J. Exp. Med. 104:193.

    PubMed  CAS  Google Scholar 

  • Skinner, S.L., 1967, Improved assay methods for renin “concentration” and “activity” in human plasma, Circ. Res. 20:391.

    PubMed  CAS  Google Scholar 

  • Skinner, S.L., Lumbers, E.R., and Symonds, E.M., 1969, Alteration by oral contraceptives of normal menstrual changes in plasma renin activity, concentration, and substrate, Clin. Sci. 36:67.

    PubMed  CAS  Google Scholar 

  • Slotkoff, L.M., and Lilienfield, L.S., 1967, Extravascular renal albumin, Am. J. Physiol. 212:400.

    PubMed  CAS  Google Scholar 

  • Slotkoff, L.M., Logan, A., Jose, P., D’Avella, J., and Eisner, G.M., 1971, Microsphere measurement of intrarenal circulation of the dog, Circ. Res. 28:158.

    PubMed  CAS  Google Scholar 

  • Smeby, R.R., and Bumpus, F.M., 1971, Renin inhibitors, in “Kidney Hormones” (J.W. Fisher, ed.) pp. 207–216, Academic Press, New York.

    Google Scholar 

  • Smith, H.W., 1951, “The Kidney: Structure and Function in Health and Disease,” p. 467, Oxford, New York.

    Google Scholar 

  • Smith, J.P., 1955, Hyaline arteriolosclerosis in the kidney, J. Pathol. Bacteriol. 69:147.

    PubMed  CAS  Google Scholar 

  • Solez, K., Fox, J.A., Miller, M., and Heptinstall, R.H., 1974a, Effects of indomethacin on renal inner medullary plasma flow, Prostaglandins 7:91.

    PubMed  CAS  Google Scholar 

  • Solez, K., Kramer, E.C., Fox, J.A., and Heptinstall, R.H., 1974b, Medullary plasma flow and intravascular leukocyte accumulation in acute renal failure, Kidney Int. 6:24.

    PubMed  CAS  Google Scholar 

  • Solez, K., Ponchak, S., Buono, R.A., Vernon, N., Finer, P.M., Miller, M., and Heptinstall, R.H., 1976a, Inner medullary plasma flow in the kidney with ureteral obstruction, Am. J. Physiol. 231:1315.

    PubMed  CAS  Google Scholar 

  • Solez, K., D’Agostini, R.J., Buono, R.A., Vernon, N., Wang, A.L., and Heptinstall, R.H.,1976b, The renal medulla and mechanisms of hypertension inthe spontaneously hypertensive rat, Am. J. Path. 85:555.

    PubMed  CAS  Google Scholar 

  • Somlyo, A.P., and Somlyo, A.V., 1971, Electrophysiological correlates of the inequality of maximal vascular smooth muscle contraction elicited by drugs, Proc. Symp. Physiol. Pharmacol. Vascular Neuroeffector Systems, p. 216, S. Karger, Basel.

    Google Scholar 

  • Speroff, L., 1973, An essay: Prostaglandins and toxemia in pregnancy, Prostaglandins 3:721.

    PubMed  CAS  Google Scholar 

  • Spielman, W.S., Davis, J.O., Freeman, R.H., and Johnson, J.A., 1974, Stimulation of aldosterone by a heptapeptide fragment of angiotensin II in the rat, Fed. Proc. 32:254.

    Google Scholar 

  • Spinelli, F.R., Wirz, H., Brucher, C., and Pehling, G., 1972, Nonexistence of shunts between afferent and efferent arterioles of juxtamedullary glomeruli in dog and rat kidneys, Nephron 9:123.

    PubMed  CAS  Google Scholar 

  • Stein, J.H., Ferris, T.F., Huprich, J.E., Smith, T.C., and Osgood, R.W., 1971, Effect of renal vasodilatation on the distribution of cortical blood flow in the kidney of the dog, J. Clin. Invest. 50:1429.

    PubMed  CAS  Google Scholar 

  • Stein, J.H., Boonjarern, S., Wilson, C.B., and Ferris, R.F., 1973, Alterations in intrarenal blood flow distribution: Methods of measurement and relationship to sodium balance, Circ. Res. 32 (Suppl. I):61.

    PubMed  Google Scholar 

  • Stein, J.H., Baehler, R.W., Cox, J.W., and Ferris, T.F., 1974, Renal hemodynamic alterations during drug-induced renal vasoconstriction and acute hemorrhagic hypotension, in “Conference on Acute Renal Failure,” (E.A. Friedman, and H.E. Eliohou, eds.) Washington, D.C., Government Printing Office, DHEW (NIH) Pub. No. 74–608.

    Google Scholar 

  • Stewart, J., 1974, Tachyphylaxis to angiotensin, in “Handbook of Experimental Pharmacology, Vol. 37, Angiotensin” (I.H. Page and F.M. Bumpus, eds.) pp. 170–184, Springer-Verlag, New York.

    Google Scholar 

  • Stjarne, L., 1973, Alpha-adrenoceptor mediated feedback control of sympathetic neurotransmitter secretion in the guinea pig vas deferens, Nature (New Biol.) 241:190.

    CAS  Google Scholar 

  • Stokes, J.B. III, and Bartter, F.C., 1974, Antidiuretic effect of intracarotid infusion of prostaglandin E2 in dogs, Circulation 50 (Suppl. III):136.

    Google Scholar 

  • Stolarczyk, J., and Carone, F.A., 1975, Effects of renal lymphatic occlusion and venous constriction on renal function, Am. J. Pathol. 78:285.

    PubMed  CAS  Google Scholar 

  • Swain, J., Heyndricks, G., Boettcher, D., and Vatner, S., 1974, Prostaglandin regulation of renal blood flow in unanesthet-ized dogs and baboons, Circulation 50 (Suppl. III):134.

    Google Scholar 

  • Symonds, E.M., Stanley, M.A., and Skinner, S.L., 1968, Production of renin by in vitro cultures of human chorion and uterine muscle, Nature 217:1152.

    PubMed  CAS  Google Scholar 

  • Szabo, G., and Magyar, Z., 1974, The origin of hilar and capsular renal lymph, Res. Exp. Med. 163:171.

    CAS  Google Scholar 

  • Takeda, T., DeBusk, J., and Grollman, A., 1969, Physiologic role of renin-like constituent of submaxillary gland of the mouse, Am. J. Physiol. 216:1194.

    PubMed  CAS  Google Scholar 

  • Tannenbaum, J., Splawinski, J.A., Oates, J.A., and Nies, A.S., 1975, Enhanced renal prostaglandin production in the dog. I. Effects on renal function, Circ. Res. 36:197.

    PubMed  CAS  Google Scholar 

  • Thorburn, G.D., Kopald, H.H., Herd, J.A., Hollenberg, N.K., O’Marchoe, C.C.C., and Barger, A.C., 1963, Intrarenal distribution of nutrient blood flow determined with Krypton85 in the unanesthetized dog, Circ. Res. 13:290.

    PubMed  CAS  Google Scholar 

  • Thurau, K., 1964, Renal hemodynamics, Am. J. Med. 36:698.

    PubMed  CAS  Google Scholar 

  • Thurau, K., 1974, Intrarenal action of angiotensin, in “Handbook of Experimental Pharmacology, Vol. 37, Angiotensin” (I.H. Page and F.M. Bumpus, eds.) pp. 475–489, Springer-Verlag, New York.

    Google Scholar 

  • Thurau, K., Dahlheim, H., Grüner, A., Mason, J., Granger, P., 1972, Activation of renin in the single juxtaglomerular apparatus by sodium chloride in the tubular fluid at the macula densa, Circ. Res. 30 (Suppl. II):182.

    Google Scholar 

  • Thurau, K., and Mason, J., 1974, The intrarenal function of the juxtaglomerular apparatus, in “MTP International Review of Science, Physiology Series One, Vol. 6, Kidney and Urinary Tract Physiology” (K. Thurau, ed.) pp. 357–389, Butterworths, London.

    Google Scholar 

  • Thurau, K., and Levine, D.Z., 1971, The renal circulation, in “The Kidney” (C.L. Rouiller and A.F. Muller, eds.) Vol. III, pp. 1–70, Academic Press, New York.

    Google Scholar 

  • Tigerstedt, R., and Bergman, P.G., 1898, Niere und Kreislauf, Scand. Arch. Physiol. 8:223.

    Google Scholar 

  • Tobian, L., 1975, Prostaglandins, hypertension, and sodium, Remarks at Symposium on the Role of Prostaglandins in Vascular Homeostasis, 59th Annual Meeting of Delegation of American Societies for Experimental Biology, Atlantic City, N.J., April 17, 1975.

    Google Scholar 

  • Tobian, L., Tomboulian, A., and Janecek, J., 1959, The effect of high perfusion pressures on the granulation of juxtaglomerular cells in an isolated kidney, J. Clin. Invest. 38:605.

    PubMed  CAS  Google Scholar 

  • Torres, V.E., Strong, C.G., Romero, J.C., and Wilson, D.M., 1973, Prostaglandins and renin in glycerol induced rabbit acute renal failure, Abstracts 1973 American Society of Nephrology, 6th Annual Meeting, p. 106.

    Google Scholar 

  • Tribe, C.R., and Heptinstall, R.H., 1965, The juxtaglomerular apparatus in scarred kidneys, Brit. J. Exp. Pathol. 46:339.

    CAS  Google Scholar 

  • Trueta, J., Barclay, A.E., Daniel, P.M., Franklin, K.J., Pritchard, M.M.L., 1947, “Studies of the Renal Circulation,” Oxford, Blackwell.

    Google Scholar 

  • Türker, R.K., Kaymakcalan, S., and Ayhan, I.H., 1968, Effect of prostaglandin E1 (PGE1) on the vascular responsiveness to norepinephrine and angiotensin in the anesthetized rat, Arzheimittel-Forsch. 18:1310.

    Google Scholar 

  • Türker, R.K., Page, I.H., and Bumpus, F.M., 1974, Antagonists of angiotensin II, in “Handbook of Experimental Pharmacology, Vol. 37, Angiotensin” (I.H. Page and F.M. Bumpus, eds.) pp. 490–499, Springer-Verlag, New York.

    Google Scholar 

  • Valtin, H., 1973, “Renal Function,” Little, Brown and Company, Boston.

    Google Scholar 

  • Vander, A.J., 1965, Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs, Am. J. Physiol. 209:659.

    PubMed  CAS  Google Scholar 

  • Vander, A.J., 1967, Control of renin release, Physiol. Rev. 47:359.

    PubMed  CAS  Google Scholar 

  • Vander, A.J., 1968, Direct effects of prostaglandin on renal function and renin release in anesthetized dog, Am. J. Physiol. 214:218.

    PubMed  CAS  Google Scholar 

  • Vane, J.R., 1974, The fate of angiotensin I, in “Handbook of Experimental Pharmacology, Vol. 37, Angiotensin,” (I.H. Page and F.M. Bumpus, eds.) pp. 17–40.

    Google Scholar 

  • Vane, J.R, and Ferreira, S.H., 1975, Interactions between brady-kinin and prostaglandins, Life Sci. 16:804.

    Google Scholar 

  • Venkatchalam, M.A., Karnovsky, M.S., 1972, Extravascular protein in the kidney, Lab. Invest. 27:435.

    Google Scholar 

  • Venuto, R.C., O’Dorisio, T., Stein, J.H., and Ferris, T.F., 1975, Uterine prostaglandin E secretion and uterine blood flow in the pregnant rabbit, J. Clin. Invest. 55:193.

    PubMed  CAS  Google Scholar 

  • von Euler, U.S., 1937, On the specific vasodilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandins and vesiglandin), J. Physiol. 88:213.

    Google Scholar 

  • von Euler, U.S., 1956, “Noradrenaline,” Charles C. Thomas, Springfield.

    Google Scholar 

  • Warren, D.J., and Ledingham, J.G.G., 1974, Renal blood flow distribution in the conscious rabbit using microspheres: The effects of hemorrhage, renal denervation and adrenalectomy, in European Colloquium on Nephron Physiology, May 16–18, 1974, p. 199, INSERM Publ. #2199, Paris.

    Google Scholar 

  • Waterson, J.G., Frewin, D.B., and Soltys, J.S., 1974, Age-related differences in catecholamine fluorescence of human vascular tissue, Blood Vessels 11:79.

    PubMed  CAS  Google Scholar 

  • Webster, M.E., and Pierce, J.V., 1963, The nature of the kallidins released from human plasma by kallikreins and other enzymes, Ann. N.Y. Acad. Sci. 104:91.

    PubMed  CAS  Google Scholar 

  • Werkö, L., Bucht, H., Josephson, B., and Ek, J., 1951, The effect of noradrenaline and adrenaline on renal hemodynamics and renal function in man, Scand. J. Clin. Lab. Invest. 3:255.

    PubMed  Google Scholar 

  • Wilde, W.S., and Vorburger, C., 1967, Albumin multiplier in kidney vasa recta analyzed by microspectrophotometry of T-1824, Am. J. Physiol. 213:1233.

    PubMed  CAS  Google Scholar 

  • Williams, M.W., Wilson, T.W., Oates, J.A., Nies, A.S., Frolich, J.C., 1974, Origin of urinary prostaglandins, J. Clin. Invest. 53:85a.

    Google Scholar 

  • Williamson, H.E, Bourland, W.A., and Marchand, G.R., 1974, Inhibition of ethacrynic acid induced increase in renal blood flow by indomethacin, Prostaglandins 8:297.

    PubMed  CAS  Google Scholar 

  • Wilson, C.B., and Dixon, F.J., 1974, Diagnosis of immunopathologic renal disease, Kidney Int. 5:389.

    PubMed  CAS  Google Scholar 

  • Wlodawer, P., and Samuelsson, B., 1973, On the organization and mechanism of prostaglandin synthetase, J. Biol. Chem. 248:5673.

    PubMed  CAS  Google Scholar 

  • Wolgast, M., 1973, Renal medullary red cell and plasma flow as studied with labeled indicators and internal detection, Acta Physiol. Scand. 88:215.

    PubMed  CAS  Google Scholar 

  • Wolgast, M., 1968, Studies in regional renal blood flow with P32-labeled red cells and small beta-sensitive semiconductor detectors, Acta. Physiol. Scand. Suppl. 313:1.

    PubMed  CAS  Google Scholar 

  • Yang, H.Y.T., Erdös, E.G., and Levin, Y., 1971, Characterization of a dipeptide hydrolase (Kininase II: angiotensin I converting enzyme), J. Pharmacol. Exp. Ther. 177:291.

    PubMed  CAS  Google Scholar 

  • Yoffey, J.M., and Courtice, F.C., 1970, “Lymphatics, Lymph, and the Lymphomyeloid Complex,” pp. 236–249, Academic Press, London.

    Google Scholar 

  • Yun, J.C.H., Delea, C.S., Bartter, F.C., and Kelly, G., 1974, Vagal control of renin secretion, Fed. Proc. 33:253.

    Google Scholar 

  • Yun, J.C.H., Delea, C.S., Bartter, F.C, and Kelly, C., 1975, Vagal control of renin secretion II, Fed. Proc. 34:311.

    Google Scholar 

  • Zehr, J.E, and Feigl, E.O. 1973, Suppression of renin activity by hypothalamic stimulation, Circ. Res. 32 (Suppl. I): 17.

    PubMed  Google Scholar 

  • Zins, G.R., 1975, Renal prostaglandins, Am. J. Med. 58:14.

    PubMed  CAS  Google Scholar 

  • Zusman, R.M., Spector, D., Caldwell, B.V., Speroff, L., Forman, B., Schneider, G., and Mulrow, P., 1973, Prostaglandin A concentrations in plasma of normal and hypertensive humans, J. Clin. Invest. 52:93a.

    Google Scholar 

  • Zusman, R.M., Spector, D., Caldwell, B.V., Speroff, L., Schneider, G., and Mulrow, P.J., 1973, The effect of chronic sodium loading and restriction on plasma prostaglandin A, E, and F concentrations in normal humans, J. Clin. Invest. 52:1093.

    PubMed  CAS  Google Scholar 

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Solez, K., Heptinstall, R.H. (1980). The Renal Circulation: Physiology and Hormonal Control. In: Schwartz, C.J., Werthessen, N.T., Wolf, S. (eds) Structure and Function of the Circulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7924-3_10

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  • DOI: https://doi.org/10.1007/978-1-4615-7924-3_10

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